Skip to content

Advertisement

  • Case report
  • Open Access
  • Open Peer Review

Delayed hemobilia due to hepatic artery pseudo-aneurysm: a pitfall of laparoscopic cholecystectomy

  • 1,
  • 1,
  • 1,
  • 2 and
  • 1Email author
BMC SurgeryBMC series – open, inclusive and trusted201616:59

https://doi.org/10.1186/s12893-016-0175-9

©  The Author(s). 2016

  • Received: 16 April 2016
  • Accepted: 10 August 2016
  • Published:
Open Peer Review reports

Abstract

Background

Hepatic artery pseudoaneurysm as a complication of laparoscopic cholecystectomy is considered a rare, potentially life threatening condition.

Case presentation

We report a case of late onset hemobilia presenting 8 months following elective laparoscopic cholecystectomy with complex biliary and vascular injury. The patient was treated surgically with primary repair of the aneurysm and hepaticojujenostomy.

Conclusion

A high index of suspicion should be raised when encountering a patient with massive upper GI bleeding and a previous history of hepatobiliary manipulation or surgery regardless of postoperative period.

Keywords

  • Hepatic Artery
  • Laparoscopic Cholecystectomy
  • Common Hepatic Artery
  • Biliary Injury
  • Elective Laparoscopic Cholecystectomy

Background

Hemobilia and vascular injuries are among the most important - albeit not necessarily the most common- complications of laparoscopic cholecystectomies (LC), due to the high morbidity and mortality associated with the condition [1–3]. The symptoms of hemobilia commonly appear within the early postoperative period or as late as 4 weeks [3]. Alongside with a detailed literature review, we report a case presenting 8 months after LC with right hepatic artery pseudo aneurysm in association with a complex injury to the common bile duct. To our knowledge there are two similar cases in the literature reporting a delayed hepatic artery pseudoanyrusm presenting up to a year following LC [4, 5] (Table 1).
Table 1

Summary of similar cases (post laparoscopic cholecystectomy hepatic artery pseudoaneurysm) reported in the literature

Author

Age

Gender

Presentation

diagnosis

Time of presentation

Procedure

Outcome

Genyk YS [18]

57 years

F

Pain, UGIB and jaundice.

HPA

2 weeks

Embolization

2 year follow up

Jean-Denis Yelle, et al. [19]

48 years

F

Pain, UGIB.

Contrast study of the fistula, ERCP& HPA

NA

Open laparotomy

6 month

Siablis D, et al. [7]

29 years

M

Pain, jaundice and UGIB.

HPA

NA

Embolization

Close follow ups

Sam T.M. Kwauk, et al. [20]

39 years

F

N\V, pain and jaundice.

CT and HPA

NA

Selective embolization

4 month

Ribeiro A, et al. [4]

57 years

F

Pain

UGI endoscopy, CT and HPA

13 months

Emergent laparotomy.

NA

de Blaauw I, et al. [21]

38 years

F

Pains and melena

NA

NA

Emergent laparotomy.

7 month

T nicholoson et al. [22]

43 years

F

Hematemesis

NA

43 days

Embolization

Well at 15 month

69 years

M

10 days

Well at 5 years

54 years

F

5 days

Well at 7 years

42 years

F

8 days

Well at 4 years

65 years

F

18 days

Well at 6 years

47 years

F

6 days

Well at 3 years

39 years

M

7 days

Well at 5 years

68 years

F

9 days

Well at 2 years

53 years

F

12 days

Well at 6 years

Dogru O, et al. [23]

62 years

F

UGIB

Ultrasound and UGI endoscopy

NA

Exploratory laparotomy

NA

Iannelli A et al., [24],

36 years

F

Not mentioned

NA

NA

Selective embolization

NA

G Roche-Nagle, et al. [25]

58 years

F

Pain, and vitally collapsed

CT & HPA

NA

Exploratory laparotomy

Uneventful recovery.

Mandur Ma et al. [15],

57 years

M

UGIB

NA

2 weeks

Embolization

Well at 22 month

63 years

F

UGIB

NA

4 weeks

Embolization

Well at 12 month

54 years

M

UGIB

NA

3 weeks

Ligation

Well at 6 months

Nakase Y, et al. [26]

63 years

F

Pain and UGIB

HPA

NA

Selective embolization

NA

Masannat YA [27]

71 years

 

Not mentioned

Angiogram

NA

Coil embolization

NA

Srinivasaiah N [28]

57 years

M

Pain and hematemesis

Ultrasound, CT and HPA

4 weeks

Radiological intervention

NA

Yao CA, et al. [29]

54 years

M

Pain, UGIB, and disturbed LFTs.

CT.

NA

Angiography with embolization

NA

Sansonna et al., [30]

44 years

F

UGIB

CT

3 weeks

Angiography with embolization

Well at 2 weeks

Paseka T et al., [31]

51 years

M

UGIB

CT & HPA.

Months

Exploratory laparotomy

Well at 6 months.

AD Mate et al., [32]

45 years

M

LGIB

HPA

15 days

Emergency laparotomy

NA

El Bouhaddouti, et al. [33]

50 years

M

Pain, jaundice and UGIB

UGI endoscopy & HPA

3 months

Emergent laparotomy.

1 year

Thamer A. Bin Traiki et al. [34]

65 years

M

Febrile (38.9 °C, (left brachial vein Thrombosis).

CT, ERCP, & HPA.

4 weeks

Angiography and embolization.

well at discharge

Tun-Abraham ME et al., [35]

67 years

M

Biliary leakage, sepsis and late intra-abdominal bleeding

CT.

NA

Angiography with embolization

No evidence of recurrent bleeding

Abdallah S et al., [36]

40 years

M

Obstructive jaundice and pain

CT & HPA.

NA

Selective embolization

NA

Chih yang Hsiao et al., [37]

40 years

M

Jaundice, pain and oozing blood from drainage.

MR & HPA.

2 weeks

Embolization and angiography.

NA

Abbreviation definition: NA not available, UGIB upper gastrpintestinal bleeding, HPA hepatic selective angiography, ERCP endoscopic retrograde cholangiography, LC laparoscopic cholecystectomy

Case presentation

A 41-year-old female patient presented to our emergency department with history of upper gastrointestinal (UGI) bleeding in the form of painless coffee ground vomitus and melena. Patient has no significant past medical history apart from uneventful elective laparoscopic cholecystectomy due to a remote episode of acute cholecystitis in another institution 8 months prior to her presentation. Upon reviewing the patient’s charts, the operation was smooth, no intraoperative complications encountered, monopolar cautery energy source was used and no intraoperative cholangiogram was obtained.

The patient had history of previous attack of minimal UGI bleeding 6 weeks post cholecystectomy, at that time an upper endoscopy and ERCP were done showing hemobilia, and a stent was placed in the common bile duct. Following that, the patient was relieved of symptoms and a CT study confirmed the presence of a small (<0.25 cm) right hepatic artery pseudoaneurysm. The patient was offered the option of embolization, however she refused the treatment and lost follow up until the current presentation.

Upon her presentation to our center, the patient was pale, tachycardiac (100–110 bpm) and normotensive. Abdomen was soft and lax with no sign of peritonitis were noted upon palpation.

Laboratory results

Hemoglobin: 10.3 g\L, Hematocrit: 33, Platelets: 44 × 109/L. Coagulation profile was normal and Liver function showed a mild elevation of the liver enzymes.

The patient was hospitalized and resuscitated, after which she was prepared for an emergency UGI endoscopy, where no bleeding source was identified in the stomach or duodenum. However, blood was noticed flowing from the major duodenal papilla raising suspicion of hemobilia. On ERCP the old stent was dislodged and a stricture was identified at the common bile duct (CBD) extending into the hepatic duct but below the bifurcation. In addition, the bile duct was filled with clots and the right hepatic artery started to fill with contrast. A plastic stent was placed across the stricture (Fig. 1). CT abdominal angiography was done showed saccular lesion at the right hepatic artery suggestive of the presence of pseudo-aneurysm (1.5 cm) (Figs. 2 and 3). Bleeding was initially controlled following the ERCP (stenting). Shortly after, the patient deteriorated again, with a drop of her hemoglobin to 7.7 g\L, she was transferred to the critical care unit, resuscitated with 4 units of PRBCS and platelets. Patient was hemodynamically stable and referred for angiography for angio-embolization, which was not successful due to failure to cannulate the common hepatic artery. The patient continued to experience gastrointestinal bleeding requiring further transfusion of blood products. She was taken to the operating room for an emergency exploratory laparotomy.
Fig. 1
Fig. 1

ECRP study: showing the stricture of the CBD (straight arrow), with filling defect of the CHD and contrast filling the right hepatic artery communication between hepatic artery and CHD (angulated arrow)

Fig. 2
Fig. 2

CT study, an axial cut: the arrows points at, A: right hepatic artery psuedoaneurysm B: Stent C: common hepatic artery

Fig. 3
Fig. 3

3D angiogram demonstrating aneurysm of hepatic artery (straight arrow)

Operative note

Exploration of the abdomen was obtained through a midline laparotomy; there was no evidence of heamoperitonium. After obtaining proximal control of the common hepatic artery, isolation of right hepatic artery was difficult. The area of the porta hepatis was thickened and edematous probably due to previous cholangitis and ERCPs. The CBD was divided to facilitate the exposure of the right hepatic artery. Following that, the right hepatic artery course was isolated and controlled proximal to the pseudo-aneurysm (Fig. 4). Upon dissection the aneurysm was accidently opened with minimal back bleeding. The wall of the pseudo aneurysm was refreshed and the right hepatic artery was closed in a primary repair fashion.
Fig. 4
Fig. 4

Intra-operative: the arrows points at, A: (white) Common bile duct, B: (black) Right hepatic artery

Roux-en-y hepatico-jujenostomy was performed. The stent has migrated and it was felt in the transverse colon, it was retrieved through a colotomy.

The patient had an uneventful recovery apart from wound infection. Her LFT gradually returned back to normal levels. After discharge the patient had been followed up for 14 months with no evidence of reoccurrence of bleeding.

Discussion

Laparoscopic cholecystectomy (LC) carries the risk of biliary and vascular iatrogenic injuries even in the hands of most experienced surgeons. Despite its many benefits in comparison to open procedure it carries a 10-fold increased risk of iatrogenic biliary and vascular injuries [3]. Laparoscopic biliary tree injuries are reported in 0.3–1 % of procedures, whereas vascular injuries reported in 0.25–0.5 % (7–9). It is well known in the literature that intraoperative bleeding is the most common manifestation of LC iatrogenic arterial injury followed by ligation. A less common manifestation of post LC iatrogenic arterial injury is presented here.

Approximately 10 % of all the reported cases of hemobilia are secondary to iatrogenic hepatic artery pseudo-aneurysms (Table 1) (8).

Upper GI hemorrhage is the most common presentation of a ruptured right hepatic artery pseudo-aneurysm into the biliary tract. However, the classic presentation of hemobilia known as Quinke’s triad is seen in less than 40 % of patients [1, 6, 7].

To date, the definite pathological explanation of post LC hemobilia is still unclear but suggested mechanisms are mechanical, thermal injuries specially monopolar coagulation during laparoscopic surgeries and surgical clips encroachments [8–10]. Bile leak and superimposed infection are important precipitating factors, It has been reported that bile acid could contribute to the injury to the vascular wall resulting in delayed healing of the vessel wall which leads to the development of pseudoaneurysm [11]. We believe the mechanism of injury in our patient is thermal, due to the presence of vascular and biliary injuries and her delayed presentation.

There are several options for diagnosing and managing such condition, Upper gastrointestinal endoscopic evaluation is fundamental to exclude the more common causes of UGI bleeding [12]. In the current Literature nearly 12 % of cases reported diagnosed endoscopically [13].

Contrast enhanced computed tomography of the abdomen aids in determining the diverse etiological causes of the hemobilia [14]. The difficulty in making the diagnosis of hemobilia might be attributable to the fact that the bleeding is usually intermittent.

The management of hemobilia is an acute emergency as patient might exsanguinate when ruptured. The therapeutic aim is to stop the bleeding and to relive biliary obstruction [13]. Transarterial embolization (TAE) is the treatment choice for all causes of hepatic artery aneurysm with a high rate of success, surgical intervention should be done for selected patients who fail a trial of embolization (12) as in our case. Angiography offers the advantage of minimally invasive procedure, and it also represents an effective treatment choice for this potentially fatal complication [15, 16].

Surgery is narrowed to conditions requiring; bile duct repair, extra-hepatic lesion or gallbladder hemorrhage, and for failure of TAE [15, 17].

The time phase between confirming the diagnosis of hemobilia and the decision for surgical intervention in case of absence or failure of embolization is crucial and must be managed meticulously by the attending surgeon. As these patients are at risk of sudden rupture and exsanguination.

Conclusion

A high index of suspicion should be considered by all treating surgeons when encountering instances of hemobilia in patients presenting with upper GI hemorrhage with a past history of cholecystectomy regardless of the post-operative period. Assessment of the hepatic arteries is an important aspect of the investigation of all biliary injuries. Intraoperative preventive measures are paramount in preventing these complications, such as careful dissection and the avoidance of cautery usage adjacent to the vasculo-biliary structures during LC.

Declarations

ᅟ

ᅟ

Funding

The authors declare that they have no financial interest to declare in relation to the content of this article.

Availability of data & material

All data and material presented in the article are available upon request.

Authors’ contributions

MA: literature review and summarized all previous similar cases, wrote part of introduction and discussion. AN: wrote the case details and clinical coarse, improved the introduction and photography. RJ: surgeon who performed vascular repair in the case, reviewed the whole manuscript, offered critiques and improved the discussion. YQ: reviewed the whole manuscript, offered critiques and improved the discussion. MA: surgeon who performed the operation, reviewed the case, wrote part of discussion and introduction. All authors read and approved the final manuscript.

Competing interest

The authors declare that they have no competing interests. All authors agree to the terms of the Biomed Central Copyright and License.

Consent for publication

Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the editor of this journal.

Ethics approval and consent to participate

This case report was approved by King Abdulaziz University Hospital ethical committee.

Disclosure

The authors declare no conflict of interest in the work to produce this article.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
(2)
Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

References

  1. Sandblom P, Saegesser F, Mirkovitch V. Hepatic hemobilia: hemorrhage from the intrahepatic biliary tract, a review. World J Surg. 1984;8(1):41–50.View ArticlePubMedGoogle Scholar
  2. Ross FP. Hemobilia (Biliary Tract Hemorrhage): history, pathology, diagnosis and treatment. Arch Surg. 1973;106(2):245.View ArticleGoogle Scholar
  3. Connor S, Garden OJ. Bile duct injury in the era of laparoscopic cholecystectomy. Br J Surg. 2006;93(2):158–68.View ArticlePubMedGoogle Scholar
  4. Ribeiro A, et al. Hemobilia due to hepatic artery pseudoaneurysm thirteen months after laparoscopic cholecystectomy. J Clin Gastroenterol. 1998;26(1):50–3.View ArticlePubMedGoogle Scholar
  5. Milburn J, et al. Right hepatic artery pseudoaneurysm thirteen months following laparoscopic cholecystectomy. EJVES Extra. 2007;13(1):1–3.View ArticleGoogle Scholar
  6. Siablis D, et al. Hemobilia secondary to hepatic artery pseudoaneurysm: an unusual complication of bile leakage in a patient with a history of a resected IIIb Klatskin tumor. World J Gastroenterol. 2005;11(33):5229–31.PubMedPubMed CentralGoogle Scholar
  7. Siablis D, et al. Hepatic artery pseudoaneurysm following laparoscopic cholecystectomy: transcatheter intraarterial embolization. Hepatogastroenterology. 1996;43(11):1343–6.PubMedGoogle Scholar
  8. Merrell SW, Schneider PD. Hemobilia--evolution of current diagnosis and treatment. West J Med. 1991;155(6):621–5.PubMedPubMed CentralGoogle Scholar
  9. Morino M. Randomized clinical trial of ultrasonic versus electrocautery dissection of the gallbladder in laparoscopic cholecystectomy (Br J Surg 2003; 90: 799–803). Br J Surg. 2003;90(10):1306.View ArticlePubMedGoogle Scholar
  10. Curet P, et al. Hepatic hemobilia of traumatic or iatrogenic origin: recent advances in diagnosis and therapy, review of the literature from 1976 to 1981. World J Surg. 1984;8(1):2–8.View ArticlePubMedGoogle Scholar
  11. Hofmann AF. Bile acids: the good, the bad, and the ugly. News Physiol Sci. 1999;14:24–9.PubMedGoogle Scholar
  12. Cattan P, et al. Hemobilia caused by a pseudoaneurysm of the hepatic artery diagnosed by EUS. Gastrointest Endosc. 1999;49(2):252–5.View ArticlePubMedGoogle Scholar
  13. Napolitano V, et al. A severe case of hemobilia and biliary fistula following an open urgent cholecystectomy. World J Emerg Surg. 2009;4:37.View ArticlePubMedPubMed CentralGoogle Scholar
  14. Rencuzogullari A, et al. Hemobilia as a result of right hepatic artery pseudoaneurysm rupture: an unusual complication of laparoscopic cholecystectomy. Int J Surg Case Rep. 2014;5(3):142–4.View ArticlePubMedPubMed CentralGoogle Scholar
  15. Madanur MA, et al. Pseudoaneurysm following laparoscopic cholecystectomy. Hepatobiliary Pancreat Dis Int. 2007;6(3):294–8.PubMedGoogle Scholar
  16. Horton KM, Smith C, Fishman EK. MDCT and 3D CT angiography of splanchnic artery aneurysms. AJR Am J Roentgenol. 2007;189(3):641–7.View ArticlePubMedGoogle Scholar
  17. Petrou A, et al. Hemobilia due to cystic artery stump pseudoaneurysm following laparoscopic cholecystectomy: case presentation and literature review. Int Surg. 2012;97(2):140–4.View ArticlePubMedPubMed CentralGoogle Scholar
  18. Genyk YS, Keller FS, Halpern NB. Hepatic artery pseudoaneurysm and hemobilia following laser laparoscopic cholecystectomy. A case report. Surg Endosc. 1994;8(3):201–4.View ArticlePubMedGoogle Scholar
  19. Yelle J-D, et al. Hemobilia complicating elective laparoscopic cholecystectomy: a case report. Can J Surg. 1996;39(3):240–2.PubMedPubMed CentralGoogle Scholar
  20. Kwauk STM, et al. Traumatic pseudoaneurysm of the hepatic artery after percutaneous liver biopsy and laparoscopic cholecystectomy in a patient with biliary cirrhosis: a case report. Can J Surg. 1998;41(4):316–20.PubMedPubMed CentralGoogle Scholar
  21. de Blaauw I, van Driel Repelaer OJ. Hemobilia as a complication of laparoscopic cholecystectomy. Ned Tijdschr Geneeskd. 1999;143(47):2380–3.PubMedGoogle Scholar
  22. Nicholson T, et al. Hepatic artery angiography and embolization for hemobilia following laparoscopic cholecystectomy. Cardiovasc Intervent Radiol. 1999;22(1):20–4.View ArticlePubMedGoogle Scholar
  23. Dogru O, et al. Hemobilia. Surg Endosc. 2003;17(9):1495–6.PubMedGoogle Scholar
  24. Iannelli A, et al. Hemobilia due to pseudoaneurysm of the right hepatic artery following laparoscopic cholecystectomy. Gastroenterol Clin Biol. 2003;27(3 Pt 1):341–3.PubMedGoogle Scholar
  25. Roche-Nagle G, Maceneaney, Harte P. Pseudo-aneurysm of the hepatic artery after laparoscopic cholecystectomy: a case report. J Minim Access Surg. 2006;2(2):73–5.View ArticlePubMedPubMed CentralGoogle Scholar
  26. Nakase Y, et al. Hemobilia and cystic artery stump pseudoaneurysm associated with liver abscess after a laparoscopic cholecystectomy: report of a case. Surg Today. 2008;38(6):567–71.View ArticlePubMedGoogle Scholar
  27. Masannat YA, et al. A rare complication of a common operation: hepatic artery pseudo aneurysm following cholecystectomy report of a case. Ir J Med Sci. 2008;177(4):397–8.View ArticlePubMedGoogle Scholar
  28. Srinivasaiah N, et al. Vascular emergencies in cholelithiasis and cholecystectomy: our experience with two cases and literature review. Hepatobiliary Pancreat Dis Int. 2008;7(2):217–20.PubMedGoogle Scholar
  29. Yao CA, Arnell TD. Hepatic artery pseudoaneurysm following laparoscopic cholecystectomy. Am J Surg. 2010;199(1):e10–1.View ArticlePubMedGoogle Scholar
  30. Sansonna F, et al. Severe hemobilia from hepatic artery pseudoaneurysm. Case Rep Gastrointest Med. 2011;2011:925142.PubMedPubMed CentralGoogle Scholar
  31. Liu Z, Yang S, Xi P. An unusual life-threatening hemobilia caused by hepatic pseudoaneurysm following choledochostomy: a case report. Case Rep Clin Med. 2016;5(02):37.View ArticleGoogle Scholar
  32. Mate AD, et al. Lower gastrointestinal bleeding due to hepatic artery pseudoaneurysm following laparoscopic cholecystectomy. J Minim Access Surg. 2013;9(1):31.View ArticlePubMedPubMed CentralGoogle Scholar
  33. El Bouhaddouti H, et al. Hemobilia due to an iatrogenic arteriobiliary fistula complicating laparoscopic cholecystectomy: a case report. Open J Gastroenter. 2014;4(06):275.View ArticleGoogle Scholar
  34. Traiki TAB, Madkhali AA, Hassanain MM. Hemobilia post laparoscopic cholecystectomy. J Surg Case Rep. 2015;2015:2.Google Scholar
  35. Tun-Abraham M, Martínez-Ordaz J, Romero-Hernandez T. Hepatic artery pseudoaneurysm: report of two cases. Cir Cir. 2013;82(6):674–9.Google Scholar
  36. Abdalla S, et al. Compressive hematoma Due to pseudoaneurysm of the right hepatic artery: a rare cause of obstructive jaundice after single-port cholecystectomy. Surg Laparosc Endosc Percutan Tech. 2015;25(1):e42–4.View ArticlePubMedGoogle Scholar
  37. Hsiao C-Y, et al. Obstructive jaundice as a complication of a right hepatic artery pseudoaneurysm after laparoscopic cholecystectomy. J Minim Access Surg. 2015;11(2):163.View ArticlePubMedPubMed CentralGoogle Scholar

Copyright

© The Author(s). 2016

Advertisement

BMC Surgery

ISSN: 1471-2482

Contact us