From: A prediction nomogram for perineural invasion in colorectal cancer patients: a retrospective study
Variable | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
OR (95%CI) | P-value | OR (95%CI) | P-value | |
Age (years) | 1.00(0.97–1.02) | 0.828 |  |  |
BMI (Kg/m2) | 0.93(0.83–1.06) | 0.277 |  |  |
Gender Female | Reference | Â | Â | Â |
 Male | 0.95(0.56–1.61) | 0.836 |  |  |
Smoking NO | Reference | Â | Â | Â |
 YES | 1.48(0.82–2.68) | 0.189 |  |  |
CA125(KU/L) ≤ 35 | Reference |  |  |  |
  > 35 | 0.19(0.02–1.57) | 0.123 |  |  |
CA199(KU/L) ≤ 35 | Reference |  |  |  |
  > 35 | 2.39(1.09–5.28) | 0.030 |  |  |
CEA(ng/ml) ≤ 5 | Reference |  |  |  |
  > 5 | 2.25(1.29–3.92) | 0.004 | 3.13(1.60–6.13) | 0.001 |
TAP(um2) ≤ 121 | Reference |  |  |  |
  > 121 | 0.84(0.34–2.12) | 0.718 |  |  |
LMR ≤ 2.76 | Reference |  |  |  |
  > 2.76 | 1.35(0.76–2.43) | 0.308 |  |  |
PLR ≤ 136.98 | Reference |  |  |  |
  > 136.98 | 2.12(1.20–3.74) | 0.009 | 2.07(1.08–3.96) | 0.028 |
NLR ≤ 2.52 | Reference |  |  |  |
  > 2.52 | 2.01(1.12–3.60) | 0.019 |  |  |
CT N-stage N0 | Reference | Â | Â | Â |
 N1-N2 | 2.55(1.46–4.42) | 0.001 | 3.44(1.74–6.80) |  < 0.001 |
CT T-stage T1-T2 | Reference | Â | Â | Â |
 T3-T4 | 1.81(1.01–3.24) | 0.047 |  |  |
Endoscopic biopsy | ||||
 Poorly | Reference |  |  |  |
 Moderately | 0.57(0.24–1.33) | 0.192 | 0.69 (0.26–1.84) | 0.457 |
 Well | 0.10(0.02–0.45) | 0.002 | 0.15 (0.03–0.74) | 0.020 |
Pathological type | ||||
 adenocarcinoma | Reference |  |  |  |
 non-adenocarcinoma | 0.57(0.17–1.94) | 0.365 |  |  |
Primary site | ||||
 Left colon | Reference |  |  |  |
 Right colon | 0.98(0.46–2.09) | 0.960 | 0.79 (0.34–1.85) | 0.593 |
 Rectum | 2.79(1.49–5.22) | 0.001 | 2.49 (1.21–5.12) | 0.013 |
Tumor gross type | ||||
 Ulceration | Reference |  |  |  |
 Infiltrative | 0.81(0.19–3.45) | 0.781 | 0.65 (0.14–2.91) | 0.572 |
 Protruded | 0.47(0.27–0.82) | 0.008 | 0.42 (0.22–0.81) | 0.010 |
 Other | 1.63(0.28–9.33) | 0.583 | 1.02 (0.16–6.66) | 0.983 |