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Table 1 Clinicopathologic characteristics of the patients with colorectal cancer (CRC)

From: A prediction nomogram for perineural invasion in colorectal cancer patients: a retrospective study

Characteristics

Training set (n = 221)

Validation set (n = 114)

PNI-negative n (%)

PNI-positive n (%)

P-value

PNI-negative n (%)

PNI-positive n (%)

P-value

Gender

  

0.942

  

0.208

 Female

59 (50)

52 (51)

 

32 (47)

28 (61)

 

 Male

60 (50)

50 (49)

 

36 (53)

18 (39)

 

Age (years)

  

0.761

  

0.454

 Median (IQR) (year)

60 (53, 69)

59.5 (54, 68.75)

 

66 (55.25, 73)

63.5 (56.25, 68.75)

 

BMI (Kg/m2)

  

0.266

  

0.436

 Median (IQR)(Kg/m2)

21.63 (20.24, 23.61)

21.52 (19.82, 23.05)

 

21.6 (20.07, 23.51)

21.05 (20.19, 22.56)

 

Smoking

  

0.243

  

0.953

 NO

90 (76)

69 (68)

 

43 (63)

28 (61)

 

 YES

29 (24)

33 (32)

 

25 (37)

18 (39)

 

CEA(ng/ml)

  

0.006

  

0.371

  ≤ 5

59 (50)

31 (30)

 

41 (60)

23 (50)

 

  > 5

60 (50)

71 (70)

 

27 (40)

23 (50)

 

CA199(KU/L)

  

0.044

  

0.347

  ≤ 35

108 (91)

82 (80)

 

63 (93)

40 (87)

 

  > 35

11 (9)

20 (20)

 

5 (7)

6 (13)

 

CA125(KU/L)

  

0.127

  

0.391

  ≤ 35

113 (95)

101 (99)

 

66 (97)

43 (93)

 

  > 35

6 (5)

1 (1)

 

2 (3)

3 (7)

 

TAP(um2)

  

0.899

  

0.934

  ≤ 121

10 (8)

10 (10)

 

4 (6)

2 (4)

 

  > 121

109 (92)

92 (90)

 

64 (94)

44 (96)

 

NLR

  

0.026

  

0.024

  ≤ 2.52

47 (39)

25 (25)

 

30 (44)

10 (22)

 

  > 2.52

72 (61)

77 (75)

 

38 (56)

36 (78)

 

PLR

  

0.013

  

0.339

  ≤ 136.98

53 (45)

28 (27)

 

31 (46)

16 (35)

 

  > 136.98

66 (55)

74 (73)

 

37 (54)

30 (65)

 

LMR

  

0.383

  

0.032

  ≤ 2.76

39 (33)

27 (26)

 

24 (35)

7 (15)

 

  > 2.76

80 (67)

75 (74)

 

44 (65)

39 (85)

 

CT N-stage

  

0.065

  

0.416

 N0

44 (37)

25 (25)

 

27 (40)

14 (30)

 

 N1-N2

75 (63)

77 (75)

 

41 (60)

32 (70)

 

CT T-stage

  

0.001

  

0.182

T1-T2

64 (54)

32 (31)

 

35 (51)

17 (37)

 

T3-T4

55 (46)

70 (69)

 

33 (49)

29 (63)

 

Primary site

  

 < 0.001

  

0.008

 Left colon

48 (40)

26 (25)

 

24 (35)

7 (15)

 

 Right colon

32 (27)

17 (17)

 

23 (34)

12 (26)

 

 Rectum

39 (33)

59 (58)

 

21 (31)

27 (59)

 

Endoscopic biopsy

  

0.004

  

0.002

 Poorly

10 (8)

16 (16)

 

5 (7)

7 (15)

 

 Moderately

91 (76)

83 (81)

 

51 (75)

39 (85)

 

 Well

18 (15)

3 (3)

 

12 (18)

0 (0)

 

Pathological type

  

0.536

  

0.875

 adenocarcinoma

111 (93)

98 (96)

 

64 (94)

44 (96)

 

 non-adenocarcinoma

8 (7)

4 (4)

 

4 (6)

2 (4)

 

Tumor gross type

  

0.037

  

0.071

 Ulceration

44 (37)

54 (53)

 

22 (32)

25 (54)

 

 Infiltrative

4 (3)

4 (4)

 

5 (7)

3 (7)

 

 Protruded

69 (58)

40 (39)

 

40 (59)

17 (37)

 

 Other

2 (2)

4 (4)

 

1 (1)

1 (2)

 
  1. BMI Body Mass Index, Primary site Primary tumor site, Smoking Smoking history, CT T-stage Tumor stage determined by CT scan, CT N-stage Lymph node stage determined by CT scan, Endoscopic biopsy Histological differentiation (grading), Pathological type Histological type, Tumor gross type Gross classification of the tumor, CEA Carcinoembryonic Antigen, CA199 Carbohydrate Antigen 199, CA125 Carbohydrate Antigen 125, TAP Aberrant Glycosylation Protein Detection, NLR Neutrophil-to-Lymphocyte Ratio, PLR Platelet-to-Lymphocyte Ratio, LMR Lymphocyte-to-Monocyte Ratio, IQR Interquartile Range
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