- Case report
- Open Access
Oral extrusion of a vertebral body replacement device after chordoma tumor growth and radiation: case report and review
BMC Surgery volume 22, Article number: 22 (2022)
Screw migration following anterior cervical discectomy and fusion is a very rare complication and it is often related to device failure. Even more exceptional is the extrusion of an intervertebral graft.
We report the second case of migration and extrusion through the oral cavity of a cervical vertebral body replacement device (expandable cylinder) in a patient that had undergone cervical corpectomy due to a vertebral chordoma.
The antecedent of radiation therapy as well as progressive tumor re-growth may have favored the development of this complication. A literature review is added.
Screw migration following anterior cervical discectomy and fusion is a very rare complication and is often related to device failure. It may provoke pharyngeal or esophageal perforation and, eventually, the inadvertent and spontaneous expulsion of the screw through the gastrointestinal tract [2, 8, 17, 21, 23]. Oral expulsion of the screw has been occasionally reported [5, 7, 9, 20], as well as the exposure or extrusion of the plate going with the screw [6, 16, 26]. Even more exceptional is the extrusion of an intervertebral graft following anterior cervical discectomy and fusion [1, 10, 11, 15, 18, 19, 22]. Despite the sometimes uneventful course of the complication, the importance lies on the risk of fistula and infection that usually entail slow recovery.
In this article, we report the exceptional case of a patient diagnosed with a cervical chordoma that presented at clinics with sudden extrusion of a cervical vertebral body expandable cylinder through the oral cavity.
A 59-year-old Caucasian female was operated on in 2005 when she was diagnosed with a cervical tumor invading the vertebral body of C3. She underwent an anterior transmandibular approach achieving tumor resection and anterior stabilization with an interbody expandable cylinder device (Fig. 1a). Histological analysis evidenced a chordoma and the patient underwent subsequent intensity-modulated radiotherapy (50 Gy). Six years later she presented with tetraparesis that was related to tumor relapse. Again, she underwent a left anterolateral submandibular approach to achieve tumor resection and spinal cord decompression. A minimal piece of tumor remained adhered to the vertebral artery. Neurological recovery was complete.
One year later the patient showed a new recurrence that invaded the vertebral bodies of C2 and C3. At this point a posterior approach was accomplished to resect the tumor and add spine stabilization C1–C6 (Fig. 1b and c). Following the procedure, the patient underwent adjuvant therapy with Cyberknife (re-irradiation with 30 Gy). Once the treatment had finished the patient noted progressive halitosis and dysphagia. She was attended at our center after sudden extrusion of the titanium cylinder that had been implanted during the first surgical operation. She referred a cough access during deglutition that resulted in the device expulsion through the oral cavity (Fig. 2). Fiber laryngoscope evaluation showed left hypopharynx widening and ipsilateral piriform recess collapse. The radiological studies showed a fistulous tract related to a decubitus ulcer in the posterior wall of the oropharynx as well as the absence of the interbody device in C3 (Fig. 3). The patient recovered uneventfully after conservative management and endovenous antibiotic therapy. Four years later, she is waiting for a new surgical procedure due to tumor progression. Figure 4 summarizes the surgical and therapeutic methods that the patient underwent throughout the process.
Oral extrusion of spinal stabilization devices is a very rare complication. It may be due to pharyngeal or esophageal perforation. It has been described regardless of the material and type of graft implanted [1, 4, 10, 11, 15, 18, 19, 22]. Thus, as far as six cases of oral extrusion of a cervical disc replacement device have been reported to date [1, 10, 15, 18, 19, 22]. Another case of oral extrusion of an anterior bone graft implanted after tissue debridement due to infection has been included in this review, despite scarce data . However, there is only one case of vertebral body replacement device extrusion published up to date . The case hereby reported is therefore the second one, and both of them share similar features, such as the oncological underlying process, the delayed course, the presence of a posterior arthrodesis besides the anterior one, or the adjuvant treatment with radiotherapy. Table 1 summarizes the specific features of these patients.
Most of the cases presented with any kind of symptom before a cough access that was responsible for device extrusion in all cases except one, in which the extrusion was spontaneous during deglutition . Three patients showed progressive radiological device failure in follow-up studies prior to the extrusion [4, 10, 22] as well as the present case. However, since a posterior fusion had also been performed, it was considered enough to stabilize the spine.
The incidence of instrumentation failure following anterior cervical plate fixations is believed to be higher than expected (18%), but only 7% of them may need surgery to fix it . However, a recent systematic review of the literature lowers the complication value to 2.1% . Another study registers an incidence of acute implant extrusion < 1% . Tumor growth and preoperative irradiation, in addition to biomechanical forces, may have contributed to shift a vertebral body replacement device in the present case. Similarly, the case reported by Faguer et al.  would be explained both by prior radiotherapy together with the biomechanical forces derived from a growing spine in the pediatric age, in absence of tumor relapse . Strategies to prevent such complication may include an anterior plate in addition to the cylinder or a circumferential fusion . The anterior plate was discarded during the first procedure due to technical nuances (lordotic angle) and the posterior fusion was not performed at that moment in order to avoid the functional limitation at such an early stage of the disease. A posterior arthrodesis was considered during the second procedure, but it was finally discarded due to the functional status of the patient (tetraparesis). Prior right and left approaches could trigger the incipient device failure observed before the third surgical procedure, when the posterior fusion was finally added.
Besides that, radiation therapy is known to interfere in the process of bone fusion . Radiation dose is also known to increase damage to the esophagus . Thus, tumor growth and radiation therapy may have favored device failure in the case hereby reported, and device failure in addition to cervical re-irradiation may be responsible for esophageal erosion and perforation.
Pharyngeal or esophageal perforation must be accurately treated in order to avoid severe or even fatal infectious complications. Management includes antibiotics, device removal, repair of the defect, and nasogastric/gastrostomy/jejunostomy tubes in order to favor defect healing [12, 16, 23]. However, all cases included in this review evolved satisfactorily in absence of direct repair of the defect.
We report the second case of migration and extrusion through the oral cavity of a cervical vertebral body replacement system after hypopharynx perforation in a patient that had undergone cervical corpectomy due to a vertebral chordoma. Neurological deficit was avoided thanks to the presence of a posterior cervical fusion. The antecedent of radiation therapy, as well as progressive tumor re-growth, may have favored the development of a decubitus ulcer in the pharynx and the migration of the interbody device respectively.
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Cavanagh SP, Tyagi A, Marks P. Extrusion of BOP-B graft orally following anterior cervical discectomy and fusion. Br J Neurosurg. 1996;10:417–8. https://doi.org/10.1080/02688699647393.
Denaro L, Longo UG, Di Martino AC, Maffulli N, Denaro V. Screw migration and oesophageal perforation after surgery for osteosarcoma of the cervical spine. BMC Musculoskelet Disord. 2017;18:52. https://doi.org/10.1186/s12891-017-1906-5.
Emery SE, Hughes SS, Junglas WA, Herrington SJ, Pathria MN. The fate of anterior vertebral bone grafts in patients irradiated for neoplasm. Clin Orthop Relat Res. 1994;300:207–12.
Faguer R, Petit D, Menei P, Fournier HD. Spontaneous oral extrusion of an acrylic vertebral reconstruction 12 years after a vertebrectomy for a Ewing’s sarcoma of the cervical spine: a case report. Neurochirurgie. 2013;59:101–4. https://doi.org/10.1016/j.neuchi.2013.03.001.
Geyer TE, Foy MA. Oral extrusion of a screw after anterior cervical spine plating. Spine (Phila Pa 1976). 2001;26:1814–6. https://doi.org/10.1097/00007632-200108150-00019.
Kapu R, Singh M, Pande A, Vasudevan MC, Ramamurthi R. Delayed anterior cervical plate dislodgement with pharyngeal wall perforation and oral extrusion of cervical plate screw after 8 years: a very rare complication. J Craniovertebr Junction Spine. 2012;3:19–22. https://doi.org/10.4103/0974-8237.110121.
Lee HC, Hee HT, Wong D. Oral extrusion of a cervical screw 15 months after anterior cervical spine plating. Hong Kong J Orthop Surg. 2004;8:127–31.
Lee WJ, Sheehan JM, Stack BC. Endoscopic extruded screw removal after anterior cervical disc fusion: technical case report. Neurosurgery. 2006;58:E589. https://doi.org/10.1227/01.NEU.0000199157.21444.BF.
Lee JS, Kang DH, Hwang SH, Han JW. Oral extrusion of screw after anterior cervical interbody fusion. J Korean Neurosurg Soc. 2008;44:259–61. https://doi.org/10.3340/jkns.2008.44.4.259.
Lin TJ, Huang FC, Chang CK. Complication of an interbody biopolymer graft extruded orally after anterior cervical discectomy and fusion. J Clin Neurosci. 2003;10:629–31. https://doi.org/10.1016/s0967-5868(03)00162-0.
Louw JA. Vomited bone graft—a complication of anterior cervical spine fusion. S Afr Med J. 1990;78:48.
Lowery GL, McDonough RF. The significance of hardware failure in anterior cervical plate fixation. Spine (Phila Pa 1976). 1998;23:181–7. https://doi.org/10.1097/00007632-199801150-00006.
Maguire PD, Sibley GS, Zhou SM, Jamieson TA, Light KL, Antoine PA, Herndon JE, Anscher MS, Marks LB. Clinical and dosimetric predictors of radiation-induced esophageal toxicity. Int J Radiat Oncol Biol Phys. 1999;45:97–103. https://doi.org/10.1016/s0360-3016(99)00163-7.
Mesfin A, Sciubba DM, Dea N, Nater A, Bierd JE, Quraishi NA, Fisher CG, Shin JH, Fehlings MG, Kumar N, Clarke MJ. Changing the adverse event profile in metastatic spine surgery: an evidence-based approach to target wound complications and instrumentation failure. Spine (Phila Pa 1976). 2016;20:262–70. https://doi.org/10.1097/BRS.0000000000001817.
Ogle K, Palsingh J, Hewitt C, Anderson M. Osteoptysis: a complication of cervical spine surgery. Br J Neurosurg. 1992;6:607–9. https://doi.org/10.3109/02688699209002381.
Pichler W, Maier A, Rappl T, Clement HG, Grechenig W. Delayed hypopharyngeal and esophageal perforation after anterior spinal fusion: primary repair reinforced by pedicled pectoralis major flap. Spine (Phila Pa 1976). 2006;31:E268–70. https://doi.org/10.1097/01.brs.0000215012.84443.c2.
Pompili A, Canitano S, Caroli F, Caterino M, Crecco M, Raus L, Occhipinti E. Asymptomatic esophageal perforation caused by late screw migration after anterior cervical plating: report of a case and review of relevant literature. Spine (Phila Pa 1976). 2002;27:E499-502. https://doi.org/10.1097/01.BRS.0000035309.04502.52.
Prusick PJ, Sabri SA, Kleck CJ. Expectoration of anterior cervical discectomy and fusion cage: a case report. J Spine Surg. 2021;7:218–24. https://doi.org/10.21037/jss-20-655.
Quadri SA, Capua J, Ramakrishnan V, Sweiss R, Cabanne M, Noel J, Fiani B, Siddiqi J. A rare case of pharyngeal perforation and expectoration of an entire anterior cervical fixation construct. J Neurosurg Spine. 2017;26:560–6. https://doi.org/10.3171/2016.10.SPINE16560.
Ravi D, Prasad KS, Rao HB, Bhushanam TV, Sivaramakrishna K, Rajiv PK. Early oral extrusion of screw after anterior cervical interbody fusion and plating: a case report. Int J Sci Stud. 2015;3:137–9. https://doi.org/10.17354/ijss/2015/288.
Salis G, Pittore B, Balata G, Bozzo C. A rare case of hypopharyngeal screw migration after spine stabilization with plating. Case Rep Otoralyngol. 2013;2013: 475285. https://doi.org/10.1155/2013/475285.
Sharma RR, Sethu AU, Lad SD, Turel KE, Pawar SJ. Pharyngeal perforation and spontaneous extrusion of the cervical graft with its fixation device: a late complication of C2–C3 fusion via anterior approach. J Clin Neurosci. 2001;8:464–8. https://doi.org/10.1054/jocn.2000.0826.
Smith MD, Bolesta MJ. Esophageal perforation after anterior cervical plate fixation: a report of two cases. J Spinal Disord. 1992;5:357–62. https://doi.org/10.1097/00002517-199209000-00015.
Smith GA, Pace J, Corriveau M, Lee S, Mroz TE, Nassr A, Fehlings MG, Hart RA, Hilibrand AS, Arnold PM, Bumpass DB, Gokaslan Z, Bydon M, Fogelson JL, Massicotte EM, Riew KD, Steinmetz MP. Incidence and outcomes of acute implant extrusion following anterior cervical spine surgery. Global Spine J. 2017;7(1 Suppl):40S-45S. https://doi.org/10.1177/2192568216686752.
Yee TJ, Swong K, Park P. Complications of anterior cervical spine surgery: a systematic review of the litareture. J Spine Surg. 2020;6:302–22. https://doi.org/10.21037/jss.2020.01.14.
Zileli M, Kilincer C, Ersahin Y, Cagli S. Primary tumors of the cervical spine: a retrospective review of 35 surgically managed cases. Spine J. 2007;7:165–73.
The authors thank Cristina Ruiz Quevedo for assistance in the translation of the manuscript.
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The article reports the description of an exceptional case, where no research, no intervention, or procedure has been performed on the subject. Thus, no ethics approval has been applied, according to the institution’s policy.
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Gutiérrez-González, R., Zamarrón, Á., Ortega, C. et al. Oral extrusion of a vertebral body replacement device after chordoma tumor growth and radiation: case report and review. BMC Surg 22, 22 (2022). https://doi.org/10.1186/s12893-022-01481-7
- Case report
- Pharyngeal perforation