Skip to main content

Liver abscess caused by fish bone perforation of Meckel’s diverticulum: a case report

Abstract

Background

Liver abscess due to gastrointestinal perforation by foreign bodies is rare. Furthermore, there are few case reports of liver abscess via the portal vein caused by perforation of the lower gastrointestinal tract by a foreign body.

Case presentation

A 54-year-old man visited our hospital because of a fever that had lasted for 1 month. There were no physical findings except for the fever. Laboratory tests showed only elevated inflammatory markers. Abdominal contrast-enhanced computed tomography revealed an abscess in the right lobe of the liver and a high-density object in the small intestine. We diagnosed him with liver abscess secondary to intestinal perforation by a foreign body. The patient underwent drainage of the liver abscess and laparoscopic surgery for perforation of the small intestine. A fish bone had perforated the top of Meckel’s diverticulum, which had been covered by the ileal mesentery. We successfully performed diverticulectomy and removed the fish bone. The patient was discharged without complications on the 13th postoperative day.

Conclusions

Liver abscess caused by foreign bodies requires multidisciplinary treatment, so we must detect and remove the cause of the abscess earlier. Liver abscess can form via the portal vein secondary to lower gastrointestinal perforation, as in this case. When exploring the cause of liver abscess, we should investigate the whole body, including the lower gastrointestinal tract.

Peer Review reports

Background

Foreign bodies in the gastrointestinal (GI) tract are often encountered in clinical practice. Most ingested foreign bodies pass through uneventfully, and the incidence of intestinal perforation after foreign body ingestion is approximately 1% [1]. Foreign body perforation usually occurs due to fishbones, chicken bones, toothpicks, needles, or pens [2]. In Japan, foreign body perforation is often caused by fish bones [3]. Reported etiologies of fish bone perforation include (1) ingestion of a fish bone longer than the luminal diameter, (2) dysmotility due to abdominal adhesions, and (3) diverticula or hernia [4].

The most common etiologies of liver abscess include (1) complications of cholangitis, (2) bloodstream dissemination via the portal vein and hepatic artery in systemic sepsis, (3) local spread from infected contiguous tissue, and (4) traumatic injury [5, 6]. Liver abscess secondary to foreign body perforation is extremely rare [7, 8]. There have been several case reports of liver abscess due to foreign body in the GI tract penetrating the liver directly. There are also a few case reports of liver abscess via the portal vein caused by perforation of the lower GI tract by a foreign body.

We herein report a case of liver abscess secondary to Meckel’s diverticulum perforation induced by a fish bone.

Case presentation

A 54-year-old man visited his primary doctor with a fever. He was prescribed common cold medicine, but his fever persisted. After visiting several hospitals, he was referred to the department of general practice at our hospital due to a 1-month history of a spiking fever. He had a medical history of hypertension. On admission, his body temperature was 37.5 °C. The findings from a physical examination were unremarkable, and there was no abdominal pain, nausea, or abdominal distension. The white blood cell count was 17,600/μL (80.5% neutrophils), and the C-reactive protein level was 7.66 mg/dL. Serum bilirubin, aspartate aminotransferase, and alanine aminotransferase levels were within normal range. Chest and abdominal X-ray findings were unremarkable; however, abdominal contrast-enhanced computed tomography (CT) revealed an abscess in the right lobe of the liver (segment 8) and a high-density linear object in the small intestine with fat stranding. There were no free air and other abdominal abscess (Fig. 1). On admission, blood cultures grew Streptococcus oralis.

Fig. 1
figure1

Enhanced computed tomography (CT) revealed an abscess in the right lobe of the liver and a needle-like foreign body in the small intestine with fat stranding

The general practitioner suspected this to be a case of fish bone bowel perforation with liver abscess, and a surgical consult was thus requested. The patient often ate fish but did not recall whether or not he had swallowed any fish bones. The liver abscess was about 5 cm in size, so we drained it by a percutaneous approach and administered ceftriaxone and metronidazole. Purulent fluid cultures from the liver abscess grew Streptococcus intermedius. He had no abdominal symptoms, so he underwent double-balloon endoscopy (DBE) before surgery. We observed the lower ileum with DBE and the intestine downstream from the ileal end by X-ray fluoroscopy, but we were unable to detect any foreign bodies, diverticula, or leakage.

We subsequently performed laparoscopic surgery due to suspicion of fish bone perforation. Laparoscopy showed that there was no ascites or abdominal abscess. Meckel’s diverticulum was located in the ileum approximately 50 cm upstream from the ileal end and had adhered to the ileal mesentery with inflammation. On peeling away the adhesion, we found a 2-cm fish bone perforating the top of Meckel’s diverticulum that had been covered by mesentery. There were no other abnormal findings of the intestine (Fig. 2). We thus performed diverticulectomy. In addition, we did not need to drain the liver abscess laparoscopically.

Fig. 2
figure2

There was a fish bone perforating the top of the Meckel’s diverticulum, which had been covered by mesentery

The histopathological report showed Meckel’s diverticulum without ectopic tissues. Recovery after the surgery was uneventful, and he was discharged on the 13th postoperative day.

Discussion and conclusions

Most ingested foreign bodies are excreted without injuring the GI tract, and only 1% of people who ingest foreign bodies experience any symptoms, such as perforation [1]. The most common sites of perforation by foreign bodies are, in descending order, the ileum, transverse colon, and sigmoid colon [9]. The present patient had Meckel’s diverticulum presenting with fish bone perforation. Meckel’s diverticulum is the most common congenital malformation of the GI tract, occurring in 2–4% of the population [10]. Most patients with Meckel’s diverticulum are asymptomatic, but a few may develop GI bleeding, abdominal pain, bowel obstruction, or perforation. Proposed causes of Meckel’s diverticulum perforation include ectopic mucosa, a foreign body, inflammatory bowel disease (IBD), and tumors [11]. There have been several reports of Meckel’s diverticulum perforation due to a fish bone; however, almost all cases developed peritonitis and underwent surgery within a few days. In our case, the Meckel’s diverticulum with perforation induced by a fish bone had become covered by the mesentery, leading to localized inflammation. We therefore believe that our patient developed liver abscess secondarily after the symptom had persisted for 1 month.

Our patient had no abdominal symptoms, and we suspected that the ingested foreign body might have been able to be removed by endoscopy. For that reason, we performed DBE. However, we were unable to detect any lesions via DBE, including foreign bodies, diverticula, and malignancy. On an examination of the resected specimen, the Meckel’s diverticulum showed a 1-cm orifice; however, this orifice might have been difficult to detect using DBE.

At surgery, we detected a fish bone perforating the top of the Meckel’s diverticulum, but the species of fish was not identified. Most previous reports on cases of Meckel’s diverticulum perforation due to a fish bone also failed to identify the species of fish [12]. The present patient often ate fish of different species and was thus unable to recall which species might have led to his condition.

Klebsiella pneumoniae is the most common pathogen causing liver abscess. However, in our case, blood cultures grew S. oralis, and purulent fluid cultures from the liver abscess grew S. intermedius. These are the same genus and constitute part of the normal bacterial flora of the human mouth, nasopharynx, and GI tract. Both cultures grew the same bacterial genus, which was not Klebsiella, and the patient developed fish bone perforation; we therefore diagnosed the liver abscess as secondary to fish bone perforation via the portal vein. Malignant neoplasm in the lower GI has been reported to cause liver abscess via the portal vein because of (1) malignancy inhibiting immunity, (2) destruction of the intestinal wall barrier, or (3) increasing pressure in the colon causing the intestinal flora to be transported into vessels [13]. However, there have been quite a few reports fish bone perforation in the lower GI tract causing liver abscess. As shown in Table 1, several case reports have described liver abscess due to a foreign body in the GI tract directly penetrating the liver; to our knowledge, however, there is only one case report with a similar presentation to ours [13]. In that case, the patient had recurrent episodes of liver abscess and a fish bone penetrating the ileum in the right lower abdomen. Blood cultures grew S. oralis, and drainage cultures from the liver abscess isolated S. intermedius, just as in our case.

Table 1 Reports on liver abscess caused by fish bone perforation

Liver abscess is a life-threatening infection, and source control is important for the management of abdominal sepsis [14]. All abscesses more than 4 cm in size should be managed by percutaneous drainage and antibiotics [5, 6]. Treating liver abscess due to non- K. pneumoniae with empirical antibiotics targeting to K. pneumoniae has also been suggested [5]. Therefore, in our case, we performed percutaneous drainage and administered ceftriaxone and metronidazole.

Liver abscess cases due to foreign bodies require multidisciplinary treatment, so we must detect and remove the cause of the liver abscess as early as possible [15]. In addition, when exploring the cause of liver abscess, we should investigate the whole body, including the lower GI tract.

Availability of data and materials

Not applicable.

Abbreviations

CT:

Computed tomography

DBE:

Double balloon endoscopy

GI:

Gastrointestinal

IBD:

Inflammatory bowel disease

References

  1. 1.

    Henderson FF, Gaston EA. Ingested foreign body in the gastrointestinal tract. Arch Surg. 1938;36:66–95.

    Article  Google Scholar 

  2. 2.

    McCanse DE, Kurchin A, Hinshaw JR. Gastrointestinal foreign bodies. Am J Surg. 1981;142:335–7.

    CAS  Article  Google Scholar 

  3. 3.

    Mizunuma K, Nakamura H, Fujitaka T, et al. A case of hepatic abscess that formed secondary to fish bone penetration. Jpn J Gastroenterol Surg. 2006;39:1811–5.

    Article  Google Scholar 

  4. 4.

    Oikawa M, Ishikawa H, Akama H, et al. Fish bone perforations of the gastrointestinal tract. J Abdom Emerg Med. 2007;27(3):441–6.

    Google Scholar 

  5. 5.

    Shelat VG, Wang Q, Chia CL, et al. Patients with culture negative pyogenic liver abscess have th e same outcomes compared to those with Klebsiella pneumoniae pyogenic liver abscess. Hepatobiliary Pancreat Dis Int. 2016;15(5):504–11.

    Article  Google Scholar 

  6. 6.

    Ahmed S, Chia CLK, Junnarkar SP, et al. Percutaneous drainage for giant pyogenic liver abscess—is it safe and sufficient? Am J Surg. 2016;211(1):95–101.

    Article  Google Scholar 

  7. 7.

    Ng CT, Htoo A, Tan SY. Fish bone-induced hepatic abscess: medical treatment. Singap Med J. 2011;52:e56–8.

    CAS  Google Scholar 

  8. 8.

    Santos SA, Alberto SC, Cruz E, et al. Hepatic abscess induced by foreign body: case report and literature review. World J Gastroenterol. 2007;13:1466–70.

    Article  Google Scholar 

  9. 9.

    Yoh K, Inoue S, Watanebe Y, et al. Intestinal perforation by fish bone: case report and review of 271 cases in the Japanese literature. Jpn J Gastroenterol Surg. 2001;34:1640–4.

    Article  Google Scholar 

  10. 10.

    Turgeon DK, Barnett JL. Meckel’s diverticulum. Am J Gastroenterol. 1990;85:777–81.

    CAS  PubMed  Google Scholar 

  11. 11.

    Shinohara T, Hirose K, Saji Y, et al. A case of perforation of meckel’s diverticulum by a fish bone. J Jpn Surg Assoc. 2004;65(9):2405–8.

    Article  Google Scholar 

  12. 12.

    Ishikawa S, Inayoshi A, Motomura Y, et al. A fish bone which penetrated the small intestine from a Meckel diverticulum. Jpn J Gastroentero Surg. 2012;45(2):210–7.

    Article  Google Scholar 

  13. 13.

    Nagashima K, Shou T, Haneda M, et al. A case report of a recurrent abscess secondary to fish bone penetration of the ileum. J Gastroenterol. 2016;113:451–6.

    Google Scholar 

  14. 14.

    Sartelli M, Chichom-Mefire A, Labricciosa FM, et al. The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines for management of intra-abdominal infections. World J Emerg Surg. 2017;12:29.

    Article  Google Scholar 

  15. 15.

    Bekki T, Fujikuni N, Amano H, et al. Liver abscess caused by fish bone perforation of stomach wall treated by laparoscopic surgery: a case report. Surg Case Rep. 2019;79(5):1–5.

    Google Scholar 

Download references

Acknowledgements

The authors would like to thank Japan Medical Communication (https://www.japan-mc.co.jp/) for the English language review.

Funding

This research didn’t receive any grant from funding agencies in the public, commercial, or not-for-profit sectors.

Author information

Affiliations

Authors

Contributions

SN acquired the data and drafted the manuscript. YI, TF, MS, HN and MO were involved in drafting in the manuscript. MO was the chief supervisor. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Yasuhito Iseki.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

The authors obtained the written informed consent for publication from this patient.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Natsuki, S., Iseki, Y., Nagahara, H. et al. Liver abscess caused by fish bone perforation of Meckel’s diverticulum: a case report. BMC Surg 20, 121 (2020). https://doi.org/10.1186/s12893-020-00783-y

Download citation

Keywords

  • Liver abscess
  • Fish bone
  • Foreign body perforation
  • Meckel’s diverticulum