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An extremely rare case of an oversized accessory spleen: case report and review of the literature

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 1Email author and
  • 3
BMC Surgery201919:45

https://doi.org/10.1186/s12893-019-0510-z

  • Received: 7 February 2019
  • Accepted: 16 April 2019
  • Published:
Open Peer Review reports

Abstract

Background

The accessory spleen is a congenital defect characterized by a separated ectopic splenic parenchyma. The size is rarely more than 4 cm. The preoperative diagnosis is prohibitive preoperatively. The aims of the present manuscript were to present the case of a patient with a rare oversize accessory spleen and a review of the literature.

Case presentation

A 15-year-old boy was admitted to the emergency department following blunt abdominal trauma.

The computed tomographic scan showed a traumatic rupture of the spleen and a 7-cm mass at the left side of the retroperitoneal space. Conservative treatment started and aborted after 4 h due to the onset of haemodynamic instability. Splenectomy was performed. An accessory spleen was discovered. A second large mass in the retroperitoneum was diagnosed as a second large accessory spleen that was also left in place. The postoperative course was uneventful, and the patient was discharged on the 7th postoperative day. Seven months later, the CT scan showed viability of both accessory spleens.

Conclusion

An accessory spleen can be variously located and the retroperitoneal position is extremely uncommon. Preoperative diagnosis is still difficult, especially in emergency and as in our case, the literature shows the difficulty of reaching a diagnosis before surgery. The main misdiagnosis is neoplastic disease and for this reason accessory spleen can be wrongly removed.

An undiagnosed pre or intra operative retroperitoneal mass, closely to the spleen, have to be managed carefully. The diagnosis of accessory spleen needs to be ever considered as if found, represents a great possibility to conduct a normal life after splenectomy (of main spleen) for trauma.

Keywords

  • Accessory spleen
  • Splenectomy
  • Trauma

Background

The spleen appears approximately at the sixth week of embryologic life as a localized proliferation of the coelomic epithelium overlying the dorsal pancreatic endoderm. The proliferating cells invade the underlying angiogenic mesenchyme; as a result, it becomes condensed and vascularized in several adjoining areas that fuse together determining the formation of a lobulated spleen [1, 2]. Subsequently, the earlier lobulated feature of the spleen disappears, retaining notches on its upper surface, the remain unchanged in the adult [1].

The spleen is localized between the 9th and 11th left ribs in abdominal cavity, between the gastric bottom and the left hemidiaphragm. With a weight of approximately 200 g, it represents the largest lymphoid organ in the body [3]. It is fundamental for the haematological and immune system and is an important reserve of approximately 10–20% of the blood volume [4].

During its growth, the spleen can develop anomalies such as complete agenesis, multiple spleens or polysplenia, accessories spleens, isolated small additional splenunculi and persistent lobulation.

The accessory spleen is a congenital defect, with a separated ectopic splenic parenchyma due to an incomplete fusion of splenic masses during embryonic growth arising from the dorsal mesogastrium [2].

The aims of the present manuscript were to present a case of a patient with a rare oversized accessory spleen and a complete update of the literature concerning this rare condition.

Case presentation

In June 2017, a 15-year-old boy was admitted to the emergency department following blunt abdominal trauma after being hit by a car while he was observing a car race.

The patient was intubated and was haemodynamically stable (blood pressure 100/60 mmHg, pulse rate 88/min); therefore, laboratory tests and CT-scan were performed.

The computed tomographic scan of the thorax and abdomen showed bilateral pleural effusions with rib fractures and a large haemoperitoneum associated with a traumatic rupture of the spleen with multiple injuries (grade III of the Organ Injury Scale, of AAST [5]) and a 7-cm mass at the left side of the retroperitoneal space (Fig. 1). A thoracic drain was inserted on the left side of the thorax, and non-operative management for the spleen started.
Fig. 1
Fig. 1

All spleens present in the patient. The injured one and the two accessories

Haemoglobin decreased from 14.4 to 8.9 g/L during hospitalization with four hours of conservative treatment, with appearance of haemodynamic instability that was considered an indication for surgery.

An incision was made on the midline. The abdomen was packed and explored. The operation began with clearance of the haemoperitoneum. The spleen appeared with multiple longitudinal lesions in the visceral aspect. It was gently grasped and displaced medially towards the incision. The avascular peritoneal attachments and ligaments are incised with by electrocautery, followed by dissection of the splenogastric ligament and ligation of the short gastric vessels near the spleen to avoid injury or late necrosis of the gastric wall. The splenorenal, splenocolic and splenophrenic ligaments were divided. To avoid pancreatic injuries, dissection was carried out in close proximity to the hilum of the spleen, where the splenic artery and veins were identified, carefully dissected, doubly ligated and fixed with suture ligatures. After removal of the spleen, haemostasis was obtained and confirmed in a systematic fashion through careful inspection of the left subphrenic area, the greater curvature of the stomach and the short gastric vessel area, as well as the splenic hilum. Inspection of these areas showed an accessory spleen connected to the omentum by a vascular pedicle that was moved to the splenic fossa and fixed to the diaphragmatic peritoneum by prolene stitches to protect it from future traumatic injuries [6] (Fig. 2). A closed drainage was placed in the splenic fossa. Assuming that the 7-cm mass on the left side of the retroperitoneal space was an accessory spleen, given the vascular dynamics of the mass at the CT scan with contrast, it was decided to leave the retroperitoneal mass.
Fig. 2
Fig. 2

The small accessory spleen fixed in the native spleen position

The postoperative course was uneventful, and the patient was discharged on the 7th postoperative day. He was followed up for 7 months, during which he was well with no complications. A CT scan performed a couple of months after the surgical procedure showed the viability of the small spleen close to diaphragm. Radiological examination revealed the mass in the retroperitoneal space confirming a second accessory spleen (Fig. 3).
Fig. 3
Fig. 3

CT-scan 7 months after the surgical procedure showing the grown intraperitoneal accessory spleen in the splenic cavity and the retroperitoneal accessory spleen

Discussion and conclusions

The spleen is an important organ for the normal activity of the immune system. In fact, in case of asplenia, the patient is subject to an increased risk of sepsis or infections that may be caused by encapsulated bacteria such as Neisseria meningitidis or Streptococcus pneumoniae [7]. Furthermore, rare overwhelming post-splenectomy infection (OPSI) may occur, with fatal results, representing a risk in case of previous splenectomy.

Asplenia, polysplenia or multiple spleens, hyposplenia, accessory splenic nodule and persistent lobulation represent the congenital malformations of the spleen. Other rare congenital anomalies are reported in the literature, but they are not relevant to our study. By contrast, splenosis is an acquired alteration.

Asplenia is a very rare condition defined by the complete absence of the spleen. This condition is also known as Ivemark’s syndrome [8].

Polysplenia, or multiple spleens, is due to the absence of fusion of the primordial germs of the spleen. Therefore, between 1 and 6 small spleens are present in the abdominal cavity with dimensions between 1 cm and 6 cm; however, the total volume does not exceed the volume of a normal spleen [9]. Often this condition is associated with other malformations (viscero-atrial situs, cardiac anomalies, venous anomalies, pancreatic anomalies, intestinal malrotation, preduodenal portal vein) or malignancies [10].

Hyposplenia can be congenital, with a small spleen that can be the cause of immunodeficiencies in children [11]. Hyposplenia can be acquired due to sickle cell anaemia, celiac disease plasmodium malariae infection or alcoholic cirrhosis [12].

The lobulation of the spleen is an alteration of the spleen’s shape that has no pathological value [13].

Splenosis is defined as auto-transplantation of splenic tissue in a heterotopic location that primarily develops as a consequence of splenic trauma or surgery [14].

An accessory spleen is defined as ectopic splenic tissue that develops due to the failure of cell fusion during embryonic development while migrating from the midline to the left upper quadrant [15, 16]. They can be localized commonly next to the hilus and vascular pedicle, the tail of the pancreas, left ovary or left testis, in the greater omentum and in the mesentery of the small and the large intestine, along the greater curvature of the stomach and in the pouch of Douglas.

Accessory spleen can be present in 16% of the population, and they are found in 10–30% at autopsy [4]. Accessory spleens are usually single (85%); in some patients there are two (14%) and only in particular cases are found three or more (1%) [2, 17]. In this case, the total volume of all supernumerary spleens exceeded the normal volume of the only one natural spleen. Macroscopically, a typical accessory spleen usually appears as a solid mass, 1–2.5 cm in diameter. Masses larger than 4 cm are very rare (2–5) with a smooth, round, ovoid or minimally lobulated shape. Microscopically, it reproduces a splenic pattern. An accessory spleen commonly has a well-defined fibrotic capsule that separates the surrounding normal tissue [18].

These accessories spleens are often asymptomatic but may present as an abdominal mass connected to complications such as torsion, haemorrhage, spontaneous rupture or cyst formation. They are diagnosed during radiological examinations for other diseases. Their diagnosis becomes mandatory only in cases of haematological disorders [19]. In fact, some disease have to be cured by splenectomy and the remnant, if a very small spleen, can represent a problem requiring reintervention [20].

Accessory spleens look like normal spleens also in terms of immunologic functions. In haematologic disorders, when splenectomy is the treatment of choice, accessory spleens have to be located and removed because they will become hyperplastic and cause recurrence of the disease.

Accessories spleens may demonstrate compensatory hypertrophy and can grow to 3–5 cm after removal of the principal spleen [21].

Preoperative diagnosis of the accessory spleen is difficult, especially in emergencies. CT scans show a well-margined mass, similar to the splenic parenchyma on the contrast phase. Magnetic imaging can also be used to evaluate tissue aspects and the vascular pedicle of the accessory spleen. Only nuclear medicine imaging can confirm the diagnosis with scintigraphy performed with 99mTC-labelled colloids or TC-99 m heat damaged red blood cells because the colloid labelled with TC 99 m is taken from the reticulum-endothelium and makes visible the spleen, liver and bone marrow; however, it is necessary to suspect the diagnosis of accessory spleen for this procedure [22]. Therefore, often only surgical excision can safely confirm the diagnosis [23]. For these reasons, many surgical procedures have been done for the purpose of diagnosis.

To perform the review of the literature, relevant articles in English were extensively searched from the MEDLINE (PubMed) database. The period of research was between 1999 and 2018. The date of the last search was July 10, 2018. The keywords used for the search were “spleen” “accessory spleen”, “retroperitoneal”, “retroperitoneal mass”, “retroperitoneal tumor”, “retroperitoneal spleen” “trauma”, “right”, and “omentum”. These words were used individually or with the Boolean operator “AND”. A total of 205 articles were analysed between 1999 at 2018. Of these 205 articles, 57 manuscripts (27, 8%) were excluded because they did not report cases of accessory spleen, 43 (21, 0%) were duplicates manuscripts, 34 manuscripts (16, 6%) analysed cases of intra-organ spleens, 31 articles (15, 1%) showed cases of splenosis and 23 manuscripts (11, 2%) were not written in English (Fig. 4). The remaining 17 manuscripts (8, 3%) reported 19 cases of accessory spleen (Table 1) [2, 15, 18, 20, 2335] and were used for our manuscript.
Fig. 4
Fig. 4

The flow chart of the Medline research

Table 1

Review of literature of retroperitoneal accessory spleen

Year

Author

Age

Sex

Side

Location

Dimension

Diagnosis

2018

Present case

1

15

M

Left

Retroperitoneal space

7 cm

Surgery

2017

Sbrana [24]

1

33

F

Left

Retroperitoneal space

7.7 × 6.0 × 5.8 cm

Surgery

2017

Xu [18]

1

65

M

Right

Parietal peritoneum

5 cm

Surgery

2017

Xia [25]

1

38

F

Left

Retroperitoneal space

4 × 2.5 cm

Surgery

2016

Maharaj [23]

1

44

M

Right

Retroperitoneal space

11 × 8 cm

Surgery

2015

Zhou [26]

1

40

F

Right

Retroperitoneal space

3,8 × 2.5 cm

Surgery

2015

Porwal [27]

1

50

M

Left

Suprarenal area

6 cm

Surgery

2014

Radu [2]

1

55

M

Left

Greater omentum

0.5/0.4 cm

Autopsy

1

52

M

Left

Hilum spleen

0.5 cm

Autopsy

2013

Toutziaris [28]

1

58

F

Left

Retroperitoneal space

5.0 × 4.0 × 3,5 cm

Surgery

2013

Wu [29]

1

30

M

Left

Retroperitoneal space

3.3 cm

Surgery

2013

Arra [15]

1

24

M

Right

Right suprarenal region

20 cm

surgery

2011

Zhang [30]

1

22

F

Left

Greater omentum

12 × 38 cm

Surgery

2011

Tjaden [31]

1

69

M

Left

Retroperitoneal space

2 × 3 cm

Surgery

2008

Bergeron [20]

2

40

F

Left

Retropancreatici tissue

1 cm

Y probe

Mesenteric of the spleen

1.4 cm

Surgery

2008

Kim [32]

1

68

M

Right

Retroperitoneal space

4 cm

Surgery

2006

Leon [33]

1

45

F

Left

Abdominal upper quadrant

6x6x4 cm

Surgery

2002

Budzynski [34]

1

45

F

Left

Retroperitoneal space

4 cm

Surgery

1999

Vural [35]

1

26

F

Left

Greater omentum

4.5 × 4.0 cm

Surgery

The analysed articles included only four cases of spleens larger than 7 cm, as in our case. This dimension is unusual because, according to the literature, these accessory spleens usually do not surpass 4 cm in diameter [18].

Diagnosis of these accessory spleens were possible preoperatively in only two cases. The first one was a patient affected by idiopathic thrombocytopenia who was operated on and found to have residual foci focused at a second procedure using a handled gamma probe [20]. The second case was a patient previously splenectomised for trauma that had a second trauma with an injured accessory spleen; in this case, the diagnosis was made on CT scan. Thirteen patients in our study underwent CT scan for diagnosis; in addition, other different diagnostic methods, including US [36], MRI [37] and PET [38] were used. One patient underwent only US, and another underwent only MRI. Finally, two cases were autopsies [2]. Of 15 cases, except for the two cases mentioned above, none obtained a diagnosis pre-operatively. The differential diagnoses ranged from adrenal gland tumour to fibroma, but all cases obtained the diagnosis of accessory spleen at surgery or after pathological examination. As in our case, the literature shows the difficulty of reaching a diagnosis before surgery. Our case was treated conservatively after diagnosis of an omental accessory spleen. At this moment, the radiologist was called to make a second examination of the CT scan; he confirmed the suspicion of a second accessory spleen. In four patients [24, 25, 29, 31], a previous splenectomy was done for various reasons, but this element did not help, and the diagnosis was not possible before surgery.

An accessory spleen can be variously located and the retroperitoneal position is extremely uncommon. Preoperative diagnosis is still difficult, especially in emergency and as in our case, the literature shows the difficulty of reaching a diagnosis before surgery. The main misdiagnosis is neoplastic disease and for this reason accessory spleen could be wrongly removed. For this reason undiagnosed pre or intra operative retroperitoneal mass, closely to the spleen, have to be managed carefully. The diagnosis of accessory spleen needs to be ever considered as if found, represents a great possibility to conduct a normal life after splenectomy (of main spleen) for trauma.

Abbreviations

AAST: 

The American Association for the Surgery of Trauma

CT: 

Computed Tomography

MRI: 

Magnetic Resonance Imaging

OPSI: 

overwhelming post-splenectomy infection

PET: 

Positron Emission Tomography

US: 

Ultrasonography

Declarations

Acknowledgements

None

Funding

The authors received no financial support for the research, authorship, and publication of this article.

Availability of data and materials

Data supporting the present findings can be obtained, after obtaining permission from the University of Catania.

The data can be obtained by corresponding Author.

Authors’ contributions

TA and PV were major contributors to writing the manuscript. MG, SE, TM and MM acquired the data. TA, MM and TM analysed and interpreted the data. CG performed the radiological examination of the abdominal cavity. TA and DCI performed a critical revision of the manuscript. All authors read and approved the final manuscript.

Ethics approval and consent to participate

This study was approved by the institutional research ethics board (hospital ethics committee), and written informed consent was obtained from the patient to participate to this case report and any accompanying images.

Consent for publication

Written informed consent for publication of their clinical details and clinical images was obtained from the parent relative of the patient. A copy of the consent form is available for review by the editor of this journal.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Authors’ Affiliations

(1)
Department of Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Cannizzaro Hospital, Via Messina 829, 95126 Catania, Italy
(2)
Department of Radiology, Cannizzaro Hospital, Catania, Italy
(3)
Department of General Surgery, E. Muscatello Hospital, Augusta, (SR), Italy

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Copyright

© The Author(s). 2019

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