- Case report
- Open Access
- Open Peer Review
This article has Open Peer Review reports available.
Cervical chylous leakage following esophagectomy that was successfully treated by intranodal lipiodol lymphangiography: a case report
© The Author(s). 2017
Received: 24 December 2016
Accepted: 22 February 2017
Published: 28 February 2017
Chylous leakage is a well-known complication after esophagectomy, but cervical chylous leakage is relatively rare, and considerable controversy remains regarding the appropriate management strategies. We herein report a case of cervical chylous leakage treated successfully by lipiodol lymphangiography.
The patient, a 70-year-old man with middle thoracic esophageal cancer, underwent radical esophagectomy with 3-field lymph node dissection and subsequently developed cervical chylous leakage. From the second postoperative day (POD2), the amount of fluid in the cervical drainage tube increased by 200–300 ml/day. We started octreotide (300 μg/day) on POD5 and etilefrine (120 mg/day) on the POD6. However, the amount of cervical discharge did not decrease. We performed lipiodol lymphangiography on POD8. Thereafter, the amount of cervical discharge finally began to decrease. We removed the drainage tube on POD13, and the patient was discharged from the hospital on POD23.
Our case suggests the clinical efficacy of lipiodol lymphangiography for cervical chylous leakage after esophagectomy.
Chylous leakage is a complication that may occur after esophagectomy, as a result of intraoperative injury or inadequate ligation of the thoracic duct, thus leading to chylous leakage. The reported incidence of this complication varies between 1.3 and 3.4% after procedures involving the thorax and neck [1, 2]. Undiagnosed postoperative chylous leakage may lead to malnutrition, sepsis, and a high mortality rate [3, 4]. Therefore, a prompt diagnosis and optimum management are required. Recently, etilefrine and octreotide have been reported to be effective in treating chylous leakage. However, conclusive findings regarding the efficacy of this regimen have yet to be obtained. We herein report a case of esophagectomy complicated by cervical chylous leakage that we treated successfully with lipiodol lymphangiography.
A 70-year-old man was referred to our hospital for the surgical management of a tumor in the thoracic upper esophagus. A physical examination and laboratory data revealed no remarkable findings. Computed tomography (CT) revealed that the tumor, which was located in the upper thoracic esophagus, had not locally invaded other organs, but there was a metastasis in the right recurrent laryngeal nerve lymph node. Upper gastrointestinal endoscopy showed a 2.5-cm-long ulcerated type 2 tumor in the upper thoracic esophagus. The extent of tumor invasion was estimated to be T2. A histopathological examination of a biopsy specimen revealed the lesion to be squamous cell carcinoma. Pathologic findings showed squamous cell carcinoma of the esophagus, (cT2, N1, M0, cStage II), determined based on the Japanese Classification of Esophageal Cancer, 10th edition. Neoadjuvant chemotherapy consisting of cisplatin and 5-fluorouracil (FP) was performed before surgery. The patient received 2 cycles of the following regimen: intravenous infusions of cisplatin (80 mg/m2) on Day 1 and continuous intravenous infusion of 5-fluorouracil (800 mg/m2) from Days 1 to 5, every 4 weeks. The tumor and lymph node metastasis were reduced after two cycles, and the neoadjuvant chemotherapy evaluation was deemed a partial response (PR).
The patient underwent subtotal esophagectomy and three-field lymphadenectomy (mediastinal lympadenectomy accompanied with neck and abdominal lymphadenectomy) via thoracoscopy and hand-assisted laparoscopy, and esophagogastrostomy was performed for reconstruction at the neck via the retrosternal route. The thoracic duct was preserved, because the thoracic duct did not approach the tumor and there was no remarkable damage to the thoracic duct during the operation. The histological diagnosis was moderately differentiated squamous cell carcinoma of the esophagus (pT1b, N1, M0, pStage II) based on the Japanese Classification of Esophageal Cancer, 10th edition.
Postoperative chylous leakage is a rare but well-known complication of general surgery. The reported incidence of this complication varies between 1.3 and 3.4% after procedures involving the thorax and neck [1, 2]. Prophylactic ligation of thoracic duct during the radical resection of esophageal cancer is usually used to prevent and treat chylous leakage. But, there is dispute about prophylactic ligation of the thoracic duct. Fu et al. showed a statistically significant increase in postoperative chylous leakage following ligation, suggesting that prophylactic thoracic ligation was not only unnecessary but also harmful . Basically, we preserve the thoracic duct other than the case that a tumor approaches it.
Chylous leakage can be life-threatening because of the significant loss of fluid, plasma protein, fat, and immunoregulatory lymphocytes, and affected patients exhibit clinical features of severe malnutrition, hyponatremia, acidosis, hypocalcaemia and susceptibility to infection. Therefore, the mortality rate is high in patients with uncontrolled chylous leakage [4, 5]. The initial treatment of chylous leakage is usually conservative therapy, such as fasting, a modified diet (low-fat, medium-chain triglycerides; parenteral nutrition; and supplemental elements), drainage of effusion, and the administration of octreotide [6, 7] and etilefrine . If conservative therapy fails, surgical interventions such as thoracic duct ligation should be considered. However, the thoracic duct and site of chylous leakage are often difficult to locate during reoperation. In addition, because such surgery is considered to increase the risk of complications, great care must be taken during reoperation.
Lipiodol lymphangiography is traditionally a diagnostic tool for identifying chylous leakage, allowing for the detection of the leakage point if surgical intervention is needed [5, 9]. However, lipiodol lymphangiography can also be used as a treatment method itself and not merely to obtain a diagnosis. Even when pleural drainage exceeded 500 ml/day, lipiodol lymphangiography proved an effective treatment in 35% of patients with chylothorax. The successful treatment rate in patients with failed non-surgical treatment was reported to be 51% . Matsumoto et al. reported that 89% patients with postoperative chylous leakage needed no surgical reintervention and that chylous leakage stopped after lipiodol lymphangiography . The mechanism of chylous leakage cessation after lipiodol lymphangiography was suspected to involve the accumulation of lipiodol at the leakage point, inducing an inflammatory reaction and acting as an embolic agent .
The traditional procedure of lymphangiography involves the subcutaneous injection of an oily contrast medium, such as lipiodol, into each foot. The traditional procedure has some problems. First by, it is an invasive procedure requiring dorsal incisions, so that it has the potential to lead infection associated with the incisions. Secondly, it is technically challenging because it requires the isolation and cannulation of the fine pedal lymphatic vessels. Even after successful placement of lymphangiogram needles, minimal movement of the patient can dislodge the needles. Whereas, Intranodal lymphangiography using ultrasound is a less-invasive approach in terms of requiring no incision compared to the traditional procedure. Intranodal lymphangiography is simpler and easier because an inguinal node is directly accessed under ultrasound guidance with a 23- gauge to 26-gauge spinal needle with use of a local anesthesia [11, 12].
We performed lipiodol lymphangiography using ultrasound-guided bilateral inguinal lymph node puncture in our patient with cervical chylous leakage following esophagectomy and successfully treated his cervical chylous leakage. Although there are several reports describing lipiodol lymphangiography as effective against thoracic chylous leakage, few have described the effective treatment of cervical chylous leakage using this technique. In the otolaryngology region, Neel et al. reported a case that was treated against the cervical chylous leakage after laryngectomy with bilateral selective neck dissection using bilateral pedal lymphangiography with iodinated oily contrast medium . But there are few other reports that were treated with lymphangiography, there are many reports treated with thoracic duct ligation for cervical chylous leakage in after the head and neck surgery. Our case demonstrated that lipiodol lymphangiography using ultrasound-guided bilateral inguinal lymph node puncture can indeed be an effective conservative treatment not only for thoracic chylous leakage, but also for cervical chylous leakage.
The limitations of a single case report must be acknowledged; although the proposed benefits of lipiodol lymphangiography by bilateral inguinal lymph node puncture may indeed increase the utilization of thoracic duct embolization, firm conclusions regarding its safety and efficacy require further investigation in a prospective series.
Cervical chylous leakage is relatively rare, and considerable controversy remains regarding the appropriate management strategies. Our case suggests the clinical efficacy of lipiodol lymphangiography for cervical chylous leakage after esophagectomy.
Availability of data and materials
The datasets supporting the conclusions of this article are included within the article.
All authors participated in the management of the patient in this case report. TT perfomed literature review and drafted the manuscript. NK supervised the case and also supervised the writing of the manuscript. MO is a chairperson of our department and supervised the entire process. All authors read and approved the manuscript.
The authors declare that they have no competing interests.
Consent for publication
Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.
Ethics approval and consent to participate
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Kaburagi T, Takeuchi H, Oyama T, Nakamura R, Takahashi T, Wada N, Saikawa Y, Kamiya S, Tanaka M, Wada T, Kitagawa Y. Intraoperative fluorescence lymphography using indocyanine green in a patient with chylothorax after esophagectomy: report of a case. Surg Today. 2013;43(2):206–10.View ArticlePubMedGoogle Scholar
- Paul S, Altorki NK, Port JL, Stiles BM, Lee PC. Surgical management of chylothorax. Thorac Cardiovasc Surg. 2009;57(4):226–8.View ArticlePubMedGoogle Scholar
- Fu JH, Hu Y, Huang WZ, Yang H, Zhu ZH, Zheng B. [Evaluating prophylactic ligation of thoracic duct during radical resection of esophageal carcinoma]. Ai Zheng. 2006;25(6):728–30.PubMedGoogle Scholar
- Parvinian A, Mohan GC, Gaba RC, Saldanha DF, Knuttinen MG, Bui JT, Minocha J. Ultrasound-guided intranodal lymphangiography followed by thoracic duct embolization for treatment of postoperative bilateral chylothorax. Head Neck. 2014;36(2):E21–4.View ArticlePubMedGoogle Scholar
- Matsumoto T, Yamagami T, Kato T, Hirota T, Yoshimatsu R, Masunami T, Nishimura T. The effectiveness of lumphangiography as a treatment method for various chyle leakages. Br J Radiol. 2009;82(976):286–90.View ArticlePubMedGoogle Scholar
- Epaud R, Dubern B, Larroquet M, Tamalet A, Guillemot N, Maurage C, Clement A, Fauroux B. Thetapeutic strategies for idiopathic chylothorax. J Pediatr Surg. 2008;43(3):461–5.View ArticlePubMedGoogle Scholar
- Snow AL, Uller W, Kim HB, Alomari AI. Percutaneous embolization of a chylous leak from thoracic duct injury in a child. Cardiovasc Intervent Radiol. 2014;37(4):1111–3.View ArticlePubMedGoogle Scholar
- Ohkura Y, Ueno M, Iizuka T, Haruta S, Tanaka T, Udagawa H. New combined medical treatment with etilefrine and octreotide for chylothorax after esophagectomy. Medicine. 2015;94(49):e2214.View ArticlePubMedPubMed CentralGoogle Scholar
- Nagan H, Fok M, Wong J. The role of lymphography in chylothorax following thoracic surgery. Br J Radiol. 1988;61(731):1032–6.View ArticleGoogle Scholar
- Alejandre-Lafont E, Krompiec C, Rau WS, Krombach GA. Effectiveness of therapeutiv lymphography on lymphatic leakage. Acta Radiol. 2011;52(3):305–11.View ArticlePubMedGoogle Scholar
- Nadolski GJ, Itkin M. Feasibility of ultrasound-guided intranodal lymphangiogram for thoracic duct embolization. J Vasc Interv Radiol. 2012;23(5):613–6.View ArticlePubMedGoogle Scholar
- Yamamoto M, Miyata H, Yamasaki M, Maeda N, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. Chylothorax after esophagectomy cured by intranodal lymphangiography: a case report. Anticancer Res. 2015;35(2):891–5.PubMedGoogle Scholar
- Patel N, Lewandowski RJ, Bove M, Nemcek Jr AA, Salem R. Thoracic ductembolization: a new treatment for massive leak after neck dissection. Laryngoscope. 2008;118(4):680–3.View ArticlePubMedGoogle Scholar