- Research article
- Open Access
- Open Peer Review
Predictive factors for successful limb salvage surgery in diabetic foot patients
© Choi et al.; licensee BioMed Central. 2014
- Received: 29 July 2014
- Accepted: 17 December 2014
- Published: 30 December 2014
The goal of salvage surgery in the diabetic foot is maximal preservation of the limb, but it is also important to resect unviable tissue sufficiently to avoid reamputation. This study aims to provide information on determining the optimal amputation level that allows preservation of as much limb length as possible without the risk of further reamputation by analyzing several predictive factors.
Between April 2004 and July 2013, 154 patients underwent limb salvage surgery for distal diabetic foot gangrene. According to the final level of amputation, the patients were divided into two groups: Patients with primary success of the limb salvage, and patients that failed to heal after the primary limb salvage surgery. The factors predictive of success, including comorbidity, laboratory findings, and radiologic findings were evaluated by a retrospective chart review.
The mean age of the study population was 63.9 years, with a male-to-female ratio of approximately 2:1. The mean follow-up duration was 30 months. Statistical analysis showed that underlying renal disease, limited activity before surgery, a low hemoglobin level, a high white blood cell count, a high C-reactive protein level, and damage to two or more vessels on preoperative computed tomography (CT) angiogram were significantly associated with the success or failure of limb salvage. The five-year survival rate was 81.6% for the limb salvage success group and 36.4% for the limb salvage failure group.
This study evaluated the factors predictive of the success of limb salvage surgery and identified indicators for preserving as much as possible of the leg of a patient with diabetic foot. This should help surgeons to establish the appropriate amputation level for a case of diabetic foot and help prevent consecutive operations.
- Diabetic foot
- Major limb amputation
- Limb salvage
Approximately 3–4% of diabetic patients develop foot ulcers sometime during their life. One of the most important strategies for the management of the diabetic foot is to prevent complications that may necessitate a major limb amputation. Even with appropriate treatment, some patients must undergo major amputation or a limb salvage operation [1, 2]. These operations are not only a huge emotional and social burden to the patients due to physical impairment, but also a financial burden [3, 4]. In recent decades, systemization of multidisciplinary management and implementation of free tissue transfer in diabetic foot treatment have led to a notable decrease in the major amputation rate [5, 6]. The key to limb salvage surgery is maximal retention of the limb and minimization of the amputation level. Free tissue transfer has become an alternative option to major amputation for elderly diabetic patients [7, 8]. Successful limb salvage, defined as a stump fit for functional ambulation, is mostly determined by the level of amputation. It is mostly affected by preservation of the talus and calcaneus because it minimizes limb length discrepancy and preserves the heel pad . The level of Chopart amputation is the most proximal among lower limb amputation locations that preserve the talus and calcaneus. Although disputable, the Chopart amputation has been defined as the threshold of successful limb salvage [10–12]. The incidence of reamputation following first toe or transmetatarsal amputation associated with diabetes mellitus has been found to be nearly one-third. Nearly 40% of patients with diabetic foot who had amputations at the foot level have a history of previous amputation [13, 14]. Surgeons should preserve as much limb length as possible. However, it is also important to avoid reamputation, since it is a massive surgical burden to diabetic patients, who usually already are in a poor general condition and face financial difficulties.
The purpose of this article is to provide information on determining the optimal amputation level, preserving as much limb length as possible without requiring additional reamputation by analyzing several predictive factors.
Approval for this retrospective study was obtained from the Institutional Review Board on Human Subjects Research and the Ethics Committee, Hanyang University Guri Hospital (IRB No. 2014–07-010). The study population was composed of patients who presented to the Department of Plastic Surgery with a diabetic foot complication from April 2004 to July 2013. The inclusion criterion was gangrene of the distal foot (distal to the metatarsophalangeal joint) that required hospitalization and amputation. Patients with complete healing without amputation were excluded from this study. The patients were divided into two groups based on their latest amputation level. The group with successful limb salvage consisted of patients with a preserved talus and calcaneus after amputation at the Chopart level or distal to it. The other group comprised patients in whom the limb could not be preserved. The patients of this group required reamputation more proximal than the Chopart level following an unsuccessful limb salvage operation.
The primary outcome measures included age, sex, smoking status, presence of comorbidities (hypertension, ischemic heart syndrome, stroke, chronic renal failure, chronic osteomyelitis), status of premorbid activities of daily living, preoperative laboratory findings, and preoperative radiologic findings. Preoperative laboratory investigations, including the hemoglobin level (Hb), white blood cell (WBC) count, glycosylated hemoglobin (HbA1c), creatinine, and C-reactive protein (CRP) levels were collected. A preoperative computed tomography (CT) angiogram was performed in all patients to evaluate the number of abnormal vessels and the state (patent, partial occlusion, total occlusion) of each vessel of the lower extremity. The secondary outcome measures were six-month and five-year survival rates. Kaplan-Meier survival estimate curves were calculated for all patients.
All statistical analyses were performed using Stata/SE 12.0 with statistical significance set at P < 0.05. To determine the statistically significant differences between the two groups, an independent t-test was used for hemoglobin and a Mann–Whitney U test was used for numerical prognostic factors. Fisher’s exact test and logistic regression analysis were used for categorical prognostic factors. Kaplan-Meier survival estimate curves were also calculated, and the log-rank test was used to compare the survival rate.
Final amputation level of both groups
Toe amputation or disarticulation
Risk factor evaluation
Results of evaluation of the value of factors as predictive of outcome
Current or Ex-smoker
Ischemic heart disease
Chronic renal failure
Premorbid ambulation state
Walking with aid
Preoperative laboratory finding
Preoperative radiologic findings
Number of damaged vessels††
None versus ≥ 1
≤1 versus ≥ 2
≤2 versus 3
Anterior tibial artery
Stenosis > 50%, Diffuse atheromatosis
Posterior tibial artery
Stenosis > 50%, Diffuse atheromatosis
Stenosis > 50%, Diffuse atheromatosis
Follow-up period and survival rate
Limb salvage success group
Limb salvage failure group
Survived at 6 months
The objective of this study was to identify any predictive factors of limb salvage success for patients with diabetic foot complications. Many studies have focused on the risk factors of diabetic foot ulceration and independent causation of multiple potential etiologic agents. However, no published studies have examined the risk factors for major amputation after limb-salvage surgery. Risk factors are important in predicting the prognosis of ulceration, yet many patients already have intractable ulceration prior to hospital admission. As a result, these studies are less helpful for the prognosis of patients in need of surgery for complicated diabetic foot [15, 16]. This study differs from previous studies in that it suggests the clinical predictors of limb salvage surgery failure. In this study, Hb, WBC, and CRP were risk factors of limb salvage surgery, but HbA1c was not. This is not surprising, given that Hb, WBC, and CRP are risk factors for diabetic foot complication, and hence a reflection of the patient’s general condition and the degree of wound inflammation . On the other hand, unlike our findings showing no significant relationship between HbA1c and limb salvage surgery outcomes, previous studies have reported that HbA1c is a risk factor for diabetic foot complications [17–19]. Chronic renal failure is also an important risk factor for proximal osteotomy. In our study, 11 of 22 patients with chronic renal failure experienced limb salvage surgery failure. In previous reports, among chronic renal failure patients on dialysis who underwent limb salvage surgery, about 50% experienced failure and went to amputation. It has been reported that the risk of lower limb amputation is greater in diabetic foot patients with kidney disease [15, 20]. However, in this study, creatinine was not a significant risk factor. Why creatinine was not found to be a risk factor for salvage failure in our study, although it has been identified as a risk factor for major limb amputation in previous studies, cannot be explained satisfactorily. The authors supposed that the reason was that creatinine levels could be controlled directly depending on the treatment for renal failure, such as dialysis [15, 21].
To reflect the uniqueness of the patients with diabetic foot complications, a simple analysis method, the ambulation state, was used in this study. This can be relatively easily measured through a simple conversation with the patient. We found that the higher the ambulation state prior to surgery, the more successful the limb salvage operation. In other words, the postoperative walking ability was proportional to one’s walking ability before the surgery. CT angiogram was used to identify the status of the blood vessels prior to surgery and has been proven effective in prior studies [22–24]. Nevertheless, no studies have examined the failure of limb salvage surgery using the results of CT angiography until now. In the results of this study, the greater the number of damaged vessels as shown on CT angiogram, the greater was the difference of the odds ratio between the two groups. When comparing each blood vessel, a reduced vascular patency was found to be associated with failure. The number of normal blood vessels and the condition of each of the blood vessels had an effect on the results. In addition, it is worth considering that the diameter of the blood vessels of the lower limb is associated with the clinical outcomes of limb salvage surgery. The vessel diameter and odds ratio are largest in the anterior tibial artery, followed by the posterior tibial artery, and last, the peroneal artery .
Stone et al.  reported the 1-, 3- and 5-year survival rates of diabetic foot patients undergoing transmetatarsal amputation to be 73%, 68%, and 62%, respectively. In our study, the 5-year survival rate of the limb salvage group was 81.6%. This may be higher because we included a high proportion of patients with toe amputation. We also found that in our success and failure groups, the 6-month survival rates showed no statistically significant difference, but the 5-year survival rate of the limb salvage surgery success group was significantly higher, meaning that the patient’s age and life expectancy may help guide further surgical treatment.
This study evaluated the factors predictive of the success of limb salvage surgery and identified indicators for preserving the limbs of patients with diabetic foot complications, allowing the establishment of an appropriate amputation level of the diabetic foot and minimizing subsequent operations.
- Singh N, Armstrong DG, Lipsky BA: Preventing foot ulcers in patients with diabetes. JAMA. 2005, 293: 217-228. 10.1001/jama.293.2.217.View ArticlePubMedGoogle Scholar
- Nather A, Siok Bee C, Keng Lin W: Value of team approach combined with clinical pathway for diabetic foot problems: a clinical evaluation. Diabet Foot Ankle. 2010, 1: 5731-Google Scholar
- Driver VR, Madsen J, Goodman RA: Reducing amputation rates in patients with diabetes at a military medical center the limb preservation service model. Diabetes Care. 2005, 28: 248-253. 10.2337/diacare.28.2.248.View ArticlePubMedGoogle Scholar
- Cho MK, Kwon SB, Kim CH, Lee YJ, Nam HS, Lee SH: Overexpression of KAI1 protein in diabetic skin tissues. Arch Plast Surg. 2014, 41: 248-252. 10.5999/aps.2014.41.3.248.View ArticlePubMedPubMed CentralGoogle Scholar
- Chiu CC, Huang CL, Weng SF, Sun LM, Chang YL, Tsai FC: A multidisciplinary diabetic foot ulcer treatment programme significantly improved the outcome in patients with infected diabetic foot ulcers. J Plast Reconstr Aesthet Surg. 2011, 64: 867-872. 10.1016/j.bjps.2010.11.024.View ArticlePubMedGoogle Scholar
- Mills JL, Armstrong DG, Andros G: Rescuing Sisyphus: the team approach to amputation prevention. J Vasc Surg. 2010, 52: 1S-2S.View ArticlePubMedGoogle Scholar
- Schirmer S, Ritter RG, Fansa H: Vascular surgery, microsurgery and supramicrosurgery for treatment of chronic diabetic foot ulcers to prevent amputations. PLoS One. 2013, 8 (9): e74704-10.1371/journal.pone.0074704.View ArticlePubMedPubMed CentralGoogle Scholar
- Oh TS, Lee HS, Hong JP: Diabetic foot reconstruction using free flaps increases 5-year-survival rate. J Plast Reconstr Aesthet Surg. 2013, 66: 243-250. 10.1016/j.bjps.2012.09.024.View ArticlePubMedGoogle Scholar
- Nather A, Wong KL: Distal amputations for the diabetic foot. Diabet Foot Ankle. 2013, 16: 4-Google Scholar
- Evans KK, Attinger CE, Al-Attar A, Salqado C, Chu CK, Mardini S, Neville R: The importance of limb preservation in the diabetic population. J Diabetes Complications. 2011, 25: 227-231. 10.1016/j.jdiacomp.2011.02.001.View ArticlePubMedGoogle Scholar
- Svensson H, Apelqvist J, Larsson : Minor amputation in patients with diabetes mellitus and severe foot ulcers achieves good outcomes. J Wound Care. 2011, 20: 261-262. 10.12968/jowc.2011.20.6.261.View ArticlePubMedGoogle Scholar
- Reyzelman AM, Hadi SUHAD, Armstrong DG: Limb salvage with Chopart’s amputation and tendon balancing. J Am Podiatr Med Assoc. 1999, 89: 100-103. 10.7547/87507315-89-2-100.View ArticlePubMedGoogle Scholar
- Dillingham TR, Pezzin LE, MacKenzie EJ: Limb amputation and limb deficiency: epidemiology and recent trends in the United States. South Med J. 2002, 95: 875-883.PubMedGoogle Scholar
- Armstrong DG, Lavery LA, Harkless LB, Van Houtum WH: Amputation and reamputation of the diabetic foot. J Am Podiatr Med Assoc. 1997, 87: 255-259. 10.7547/87507315-87-6-255.View ArticlePubMedGoogle Scholar
- Yang Y, Ostbye T, Tan SB, Abdul Salam ZH, Ong BC, Yang KS: Risk factors for lower extremity amputation among patients with diabetes in singapore. J Diabetes Complications. 2011, 25: 382-386. 10.1016/j.jdiacomp.2011.08.002.View ArticlePubMedGoogle Scholar
- Lee KM, Kim WH, Lee JH, Choi MS: Risk factors of treatment failure in diabetic foot ulcer patients. Arch Plast Surg. 2013, 40: 123-128. 10.5999/aps.2013.40.2.123.View ArticlePubMedPubMed CentralGoogle Scholar
- Sun JH, Tsai JS, Huang CH, Lin CH, Yang HM, Chan YS, Hsieh SH, Hsu BR, Huang YY: Risk factors for lower extremity amputation in diabetic foot disease categorized by Wagner classification. Diabetes Res Clin Pract. 2012, 95: 358-363. 10.1016/j.diabres.2011.10.034.View ArticlePubMedGoogle Scholar
- Resnick HE, Carter EA, Sosenko JM, Henly SJ, Fabsitz RR, Ness FK, Welty TK, Lee ET, Howard BV: Incidence of lower-extremity amputation in American Indians: the strong heart study. Diabetes Care. 2004, 27: 1885-1891. 10.2337/diacare.27.8.1885.View ArticlePubMedGoogle Scholar
- Hennis AJ, Fraser HS, Jonnalagadda R, Fuller J, Chaturvedi N: Explanations for the high risk of diabetes-related amputation in a Caribbean population of black african descent and potential for prevention. Diabetes Care. 2004, 27: 2636-2641. 10.2337/diacare.27.11.2636.View ArticlePubMedGoogle Scholar
- Stone PA, Back MR, Armstrong PA, Flaherty SK, Keeling WB, Johnson BL, Shames ML, Bandyk DF: Midfoot amputations expand limb salvage rates for diabetic foot infections. Ann Vasc Surg. 2005, 19: 805-811. 10.1007/s10016-005-7973-3.View ArticlePubMedGoogle Scholar
- Wong KL, Nather A, Liang S, Chang Z, Wong TT, Lim CT: Clinical outcomes of below knee amputations in diabetic foot patients. Ann Acad Med Singapore. 2013, 42: 388-394.PubMedGoogle Scholar
- Fleischmann D, Hallett RL, Rubin GD: CT angiography of peripheral arterial disease. J Vasc Interv Radiol. 2006, 17: 3-26. 10.1097/01.RVI.0000191361.02857.DE.View ArticlePubMedGoogle Scholar
- Dyet JF, Nicholson AA, Ettles DFE: Vascular imaging and intervention in peripheral arteries in the diabetic patient. Diabetes Metab Res Rev. 2000, 16: S16-S22. 10.1002/1520-7560(200009/10)16:1+<::AID-DMRR131>3.0.CO;2-W.View ArticlePubMedGoogle Scholar
- Park SC, Choi CY, Ha YI, Yang HE: Utility of toe-brachial index for diagnosis of peripheral artery disease. Arch Plast Surg. 2012, 39: 227-231. 10.5999/aps.2012.39.3.227.View ArticlePubMedPubMed CentralGoogle Scholar
- Deshatty DD, Shubha R: Study of external diameter of crural arteries and their clinical significance. J Evol Med Dent Sci. 2013, 49: 9539-9547.View ArticleGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2482/14/113/prepub
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