Table 7 Sinus surgery
From: Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review
Author and year | Comparator and patients per arm (n) | Primary endpoint | Principal results |
|---|---|---|---|
Chandra 2003[16] | Floseal® (20) | Effects on mucosal healing | Not significant differences in the extent of surgery or the need for additional nasal packing. The Floseal® groups showed increased granulation tissue (p = 0.007) and adhesion formation (0.006). |
Thrombin-soaked gelatine foam (20) | |||
Chandra 2005[17] | Floseal® (10) | Long-term follow-up of previous Floseal® study group (Chandra 2003) | Higher overall incidences of adhesions (p = 0.013) and adhesions requiring lysis (p = 0.046) in the Floseal® group. |
Thrombin-soaked gelatine foam (8) | |||
Baumann 2003[19] | Floseal® (50) | Intra- and postoperative bleeding, cost of application, and length of hospital stay | Equal intraoperative haemostasis in both groups. A 36% shorter length of hospital stay in the Floseal® group. High postoperative comfort in the Floseal® group. The higher costs of Floseal® application were largely compensated for by the lower hospitalisation costs. |
Merocel® (50) | |||
Jameson 2006[20] | Floseal® (43) | Bleeding and healing | A shorter time to the cessation of bleeding in the Floseal® group (p = 0.028). Less crusting in the Floseal® group at 1 week and significantly less pain on Floseal®-treated patients (p = 0.027) |
Saline-soaked neuropatties (47) | |||
Shrime 2007[18] | Floseal® (37) | Incidence and outcomes of and risk factors for synechia formation | A higher incidence of synechia formation in the Floseal® group. Similar intra- and postoperative complications. |
Conventional method (135) | |||
Beyea 2011[21] | Floseal® (10) | Nasal bleeding | NS difference in blood loss between groups (p = 0.93). |
Hemostase® (8) |