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Table 7 Sinus surgery

From: Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review

Author and year Comparator and patients per arm (n) Primary endpoint Principal results
Chandra 2003[16] Floseal® (20) Effects on mucosal healing Not significant differences in the extent of surgery or the need for additional nasal packing. The Floseal® groups showed increased granulation tissue (p = 0.007) and adhesion formation (0.006).
Thrombin-soaked gelatine foam (20)
Chandra 2005[17] Floseal® (10) Long-term follow-up of previous Floseal® study group (Chandra 2003) Higher overall incidences of adhesions (p = 0.013) and adhesions requiring lysis (p = 0.046) in the Floseal® group.
Thrombin-soaked gelatine foam (8)
Baumann 2003[19] Floseal® (50) Intra- and postoperative bleeding, cost of application, and length of hospital stay Equal intraoperative haemostasis in both groups. A 36% shorter length of hospital stay in the Floseal® group. High postoperative comfort in the Floseal® group. The higher costs of Floseal® application were largely compensated for by the lower hospitalisation costs.
Merocel® (50)
Jameson 2006[20] Floseal® (43) Bleeding and healing A shorter time to the cessation of bleeding in the Floseal® group (p = 0.028). Less crusting in the Floseal® group at 1 week and significantly less pain on Floseal®-treated patients (p = 0.027)
Saline-soaked neuropatties (47)
Shrime 2007[18] Floseal® (37) Incidence and outcomes of and risk factors for synechia formation A higher incidence of synechia formation in the Floseal® group. Similar intra- and postoperative complications.
Conventional method (135)
Beyea 2011[21] Floseal® (10) Nasal bleeding NS difference in blood loss between groups (p = 0.93).
Hemostase® (8)