After-surgery pain is an extremely variable clinical condition, in a continuously changing evolution, where environmental and personal factors have combinations and results not easily predictable. It puts the subject into a state of physical and mental subjection so as of powerlessness. It could be feared more than the surgery itself and anesthesia. Such fears can bring the patient to delay surgery, increasing its risks, scope and post-surgery pain itself: this may lead to a progression of the pathological condition, and make recovery and convalescence more complicate .
After-surgery pain treatment allows to: limit neurovegetative storms and the states of neuroendocrine activation; avoid, as much as possible, the development of "persistent pain" situations; facilitate the re-establishment of the previous psyco-physical function and functional state, so improving the general "patient satisfaction".
The results of recent case studies have shown that after surgery pain management is insufficient; this implies negative economic consequences to the National Health Service, including the increase of unsatisfied patients number, longer hospitalization and frequent re-hospitalizations .
The aim of our study is to compare the analgesic effect Ketorolac + Tramadole vs the analgesic effect of Meperidine only, in pain management after Major Surgery. We also focused our attention on the possible occurrence of adverse reactions, identified as every effect occurring within 48 hours after surgery (nausea, vomit, headache, vertigo).