Intussusception remains a rare condition in adults, representing 1% of bowel obstructions or 0.003% to 0.02% of all hospital admissions. 90% of adult intussusceptions have an organic cause, 60% developing due to neoplasms (60% malign and 24–40% benign) . Adult colonic intussusception is caused by a primary carcinoma in 65–70% of all cases. Colonic lipoma as leading cause is uncommon . They are more common in women with a peak incidence between 50 and 60 years old [4, 5]. Most are found in the cecum, located submucosally. Colonic lipoma typically presents as a sessile polypoid mass, arising from the submucosa with an intact mucosa. Infrequently, lipomas of the colon are pedunculated, with ulcerated or necrotic overlying mucosa. Several possible mechanisms have been proposed to explain this situation: (a) a tumor may act as a foreign body causing violent peristalsis, so that the contracted central part of the bowel easily moves into the dilated distal part; (b) intussusception may be due to altered muscle function caused by a tumor or bowel paralysis; and (c) a tumor may be grasped and pulled forward by traction [6, 7]. The clinical presentation of intussusceptions can be very diverse in the adult [3, 4, 6]. Abdominal pain is the most common symptom followed by obstruction and palpable mass. Common symptoms are abdominal pain, vomiting, and bloody stools presenting for many days or even weeks. Physical examination may show a palpable “sausage-like” mass, and blood tests may show significant leucocytosis. Since only about 9% to 10% of adult intussusceptions present with the typical triad of abdominal pain, palpable abdominal mass and bloody stool. A study in the Mayo clinic showed that 94% of lipomas are asymptomatic however isolated lipomas may present with non specific abdominal pain, bleeding and constipation . The preoperative diagnosis is usually very difficult [1, 4, 8]. Imaging modalities can contribute to the preoperative diagnosis of colonic lipomas. Barium enema usually reveals a filling defect; however this finding is no specific of colonic lipoma or any other type of colonic neoplasm. On CT a lipoma has a uniform appearance with fat-equivalent density and a smooth border(−40 till −120 Hounsfield units) . However, even if the radiological image may suggest strong evidence for the existence of a lipoma, radiologists will often also mention other more malignant options in their differential diagnosis. Recent reports  in the literature have suggested that abdominal CT scanning is the preferred radiologic modality for diagnosing intussusception from colonic lipomas. The sensitivity of CT scan to correctly diagnose intussusceptions has been reported from 71.4%-87.5% while its specificity in adults has been reported to be 100% as verified by the subsequent surgery. For patients with features typical of colonic lipoma, CT reliably confirms the diagnosis. However, intussuscepted lipomas may not demonstrate normal fat attenuation and may have a heterogeneous appearance reflecting the degree of infarction and fat necrosis present at the time of radiologic evaluation . Some investigators have recommended enteroclysis for intussusception diagnosis, but only one case has been reported . Magnetic resonance imaging is particularly able to detect fatty lesions because of signal intensity characteristics typical for adipose tissue mainly on T1-weighted and fat-suppressed images. However, this imaging modality is seldom used for detecting and studying intestinal neoplastic lesions . Colonoscopy can usually distinguish colonic lipomas from cancer and other neoplasias, especially when the overlying mucosa is intact. However it should be kept inmind that in few cases, accurate preoperative diagnosis can be difficult . In view of the uncertain etiology and diagnosis and high incidence of malignancy (approaching 50%), the treatment of intussusception in adults is invariably surgical resection [2, 4–6]. The majority of authors recommend surgery as the standard method of treatment for every colonic lipoma greater than 2 cm in size [4, 6]. Surgical treatment includes resection, colotomy with local excision, limited colon resection, segmental resection, hemicolectomy, or subtotal colectomy. The choice of any of the above mentioned surgical interventions mainly depends on the lipoma size, location, and the presence or absence of definite preoperative diagnosis or disease complications. The time and the type of the surgical intervention differ and depend on the site, cause, and degree of obstruction. Most surgeons agree that resection is necessary, particularly in colonic intussusceptions and in older patients, because of the possibility of a malignant tumor. Some authors have recommended a selective approach to resection, depending on the site of intussusception, which influences the type of pathology [1, 14]. Chang and colleagues  recommended operative reduction for small-bowel intussusceptions but not for colonic intussusceptions. Gupta and colleagues  reported resection in 70% of colonic intussusceptions. During last years a few selected cases of successful laparoscopicresection under colonoscopic guidance of symptomatic colonic lipomas have been reported [17, 18]. The present case highlights the possibility of intussusception with an unusually benign cause, such as lipoma, when adult patients present with nonspecific abdominal symptoms and small bowel obstruction. Diagnosis can be determined radiologically or colonoscopically. CT imaging remain the methods of choice for studying abdominal lipomas, particularly those rising into the layers of the colonic wall. Surgical resection remains the treatment of choice and produces an excellent prognosis. Additional reports of intussusception in the adult population are needed to optimize the standard management for this uncommon disease.