Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection

Table 6 Summary of studies on IL-6 in predicting complications after surgery

References	Study design	Study interval	Object	N
Lenski et al. [11]	Prospective	2011–2016	Spine surgery	98
Song et al. [7]	Retrospective	2017–2018	General surgery	3810
Yu et al. [12]	Prospective	2017	General surgery	146
Montero et al. [32]	Prospective	2021	Pediatric acute appendicitis (PAA)	205
Chen et al. [13]	Prospective	2020–2021	Cardiac surgery	694
Rettig et al. [31]	Prospective	Without introduction	Major abdominal surgery	137
Xie et al. [33]	Prospective	2014–2016	Crohn’s disease	118
Endpoint		Time point	Cut-off value or AUC of IL-6
Surgical site infection		The day of diagnosis of SSI	15.30 pg/mL
Intra-abdominal infection		POD 1 and POD 3	0.79 on POD 3
Nosocomial infection		POD 1 and POD 2	0.86 on POD 1
Complicated PAA		Prior to the scheduled intervention	60.25 pg/mL
Postoperative pneumonia		PODs 1, 2, 3, 4, and 5	0.78 on POD 1
Postoperative complications		PODs 0, 1, 3, and 7	432.00 pg/mL on POD 1
Intra-abdominal septic complications		PODs 0, 1, 3, and 5	0.71 on POD 1

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