Interleukin-6 on postoperative day three as an early predictor of infections following laparoscopic gastric cancer resection

Table 3 Comparison of the accuracy of CRP, PCT, and IL-6 to predict infection

Date	Cut-off value	AUC (95% CI)	Youden index	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	P Value
POD 3
CRP (mg/L)	150.00	0.76	0.41	61.90	78.90	24.50	94.80	< 0.001
PCT (ng/mL)	1.39	0.80	0.46	81.00	65.40	21.00	96.80	< 0.001
IL-6 (pg/mL)	84.00	0.84	0.68	85.70	82.70	36.00	98.10	< 0.001
POD 5
CRP (mg/L)	64.50	0.74	0.40	76.20	63.80	19.30	95.90	< 0.001
PCT (ng/mL)	0.77	0.77	0.43	57.10	85.40	30.80	94.60	< 0.001
IL-6 (pg/mL)	58.10	0.78	0.58	61.90	96.20	41.90	95.40	< 0.001

CRP = C-reactive protein, PCT = procalcitonin, IL-6 = interleukin-6, POD = Postoperative day, AUC = area under curve, PPV = positive predictive value, NPV = negative predictive value
Bold values indicate statistical significance at a P < 0.05

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