Table 3 Univariable and multivariable Cox proportional hazards regression analysis for PFS and OS in the original cohort
Variables | PFS | OS | ||||||
|---|---|---|---|---|---|---|---|---|
Univariable | Multivariable | Univariable | Multivariable | |||||
Median PFS (mo) | P | HR (95% CI) | P | Median OS (mo) | P | HR (95% CI) | P | |
Sex | 0.385 | 0.980 | ||||||
Male | 3 | 24 | ||||||
Female | 4 | 18 | ||||||
Age | 0.251 | 0.128 | ||||||
≤60 | 4 | 22 | ||||||
>60 | 4 | 15 | ||||||
Primary tumor site | 0.056 | 1.37 (0.75, 2.51) | 0.300 | 0.011 | 1.47 (0.67, 2.80) | 0.241 | ||
Colon | 5 | 31 | ||||||
Rectum | 2 | 9 | ||||||
Grade | 0.227 | < 0.001 | 1.99 (0.50, 7.84) | 0.326 | ||||
G1 and G2 | 5 | 88 | ||||||
G3 | 3 | 11 | ||||||
Differentiation | 0.012 | 1.86 (1.02, 3.41) | 0.043 | < 0.001 | 3.70 (1.09–12.48) | 0.035 | ||
NET | 9 | 62 | ||||||
NEC | 2 | 9 | ||||||
Clinical T stage | 0.724 | 0.745 | ||||||
T1, T2 | 5 | 21 | ||||||
T3, T4 | 4 | 22 | ||||||
Clinical N stage | 0.340 | 0.318 | ||||||
N0 | 3 | 62 | ||||||
N1 | 4 | 21 | ||||||
Site of metastasis | 0.861 | 0.310 | ||||||
Single-organ | 4 | 26 | ||||||
Multiple-organ | 4 | 18 | ||||||
PTR | 0.578 | 0.964 | ||||||
Yes | 4 | 24 | ||||||
No | 4 | 16 | ||||||