From: The value of multimodal treatment in anaplastic thyroid cancer patients with distant metastasis
Characteristics | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Gender | Â | Â | Â | Â | Â | Â |
 Female | reference |  |  | reference |  |  |
 Male | 0.71 | 0.56–0.90 | 0.0049 | 0.85 | 0.66–1.09 | 0.183 |
Age | Â | Â | Â | Â | Â | Â |
 ≤65 | reference |  |  | reference |  |  |
 >65 | 1.50 | 1.16–1.93 | 0.0016 | 1.31 | 1.01–1.70 | 0.046 |
Race | Â | Â | Â | Â | Â | Â |
 Non-Hispanic White | reference |  |  |  |  |  |
 Hispanic White | 1.19 | 0.86–1.64 | 0.28 |  |  |  |
 Black | 0.99 | 0.59–1.67 | 0.98 |  |  |  |
 Others | 0.96 | 0.70–1.33 | 0.81 |  |  |  |
T stage | Â | Â | Â | Â | Â | Â |
 T1/2 | reference |  |  |  |  |  |
 T3 | 1.29 | 0.72–2.33 | 0.39 |  |  |  |
 T4 | 1.36 | 0.79–2.34 | 0.27 |  |  |  |
N stage | Â | Â | Â | Â | Â | Â |
 N0 | reference |  |  |  |  |  |
 N1 | 0.90 | 0.68–1.18 | 0.43 |  |  |  |
Tumor Diameter | Â | Â | Â | Â | Â | |
 ≤6 cm | reference |  |  | reference |  |  |
 >6 cm | 1.66 | 1.27–2.14 | < 0.0001 | 1.20 | 1.10–1.30 | < 0.0001 |
Tumor Extension | Â | Â | Â | Â | Â | Â |
 Limited to Thyroid | reference |  |  |  |  |  |
 Extrathyroidal Extension | 0.94 | 0.70–1.27 | 0.69 |  |  |  |
Distant Lymph Node Metastasis | Â | Â | Â | Â | ||
 No | reference |  |  |  |  |  |
 Yes | 1.13 | 0.87–1.45 | 0.36 |  |  |  |
Bone Metastasis | Â | Â | Â | Â | Â | |
 No | reference |  |  |  |  |  |
 Yes | 0.88 | 0.66–1.17 | 0.37 |  |  |  |
Brain Metastasis | Â | Â | Â | Â | Â | |
 No | reference |  |  |  |  |  |
 Yes | 1.10 | 0.67–1.80 | 0.70 |  |  |  |
Liver Metastasis | Â | Â | Â | Â | Â | |
 No | reference |  |  |  |  |  |
 Yes | 0.94 | 0.61–1.45 | 0.77 |  |  |  |
Lung Metastasis | Â | Â | Â | Â | Â | |
 No | reference |  |  | reference |  |  |
 Yes | 1.57 | 1.12–2.21 | 0.0089 | 1.58 | 1.12–2.24 | 0.009 |
Multiple Organ Metastases | Â | Â | Â | Â | ||
 No | reference |  |  |  |  |  |
 Yes | 1.13 | 0.85–1.50 | 0.39 |  |  |  |
Marital status | Â | Â | Â | Â | Â | |
 Single (never married) | reference |  |  |  |  |  |
 Married | 0.90 | 0.62–1.31 | 0.58 |  |  |  |
 Divorced/Separated/Widowed | 1.34 | 0.89–2.08 | 0.17 |  |  |  |
 Unknown | 0.93 | 0.28–3.09 | 0.91 |  |  |  |
Surgery to Primary Site | Â | Â | Â | Â | Â | Â |
 No | reference |  |  | reference |  |  |
 Non-thyroidectomy | 0.60 | 0.41–0.90 | 0.01 | 0.69 | 0.46–1.03 | 0.067 |
 Thyroidectomy | 0.52 | 0.39–0.69 | < 0.0001 | 0.61 | 0.45–0.81 | 0.001 |
Radiotherapy | Â | Â | Â | Â | Â | Â |
 No | reference |  |  | reference |  |  |
 Yes | 0.59 | 0.47–0.76 | < 0.0001 | 0.69 | 0.53–0.90 | 0.005 |
Chemotherapy | Â | Â | Â | Â | Â | Â |
 No | reference |  |  | reference |  |  |
 Yes | 0.39 | 0.30–0.50 | < 0.0001 | 0.55 | 0.42–0.71 | < 0.0001 |