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Table 4 Details of the predictive model used to calculate the probability of IAC in pGGNs measurements ≤ 2 cm

From: Construction and validation of a predictive model of invasive adenocarcinoma in pure ground-glass nodules less than 2 cm in diameter

Risk factors

Estimate

Std. Error

Statistic

OR (95% CI)

p

Intercept

-12.759

4.13

 

0

0.002

Maximum diameter

2.41

0.417

5.784

11.130 (5.044, 25.966)

< 0.001

Age

0.053

0.018

2.871

1.054 (1.018, 1.094)

0.004

Lymphocyte

-0.027

0.308

-0.089

0.973 (0.527, 1.769)

0.929

PNI

0.081

0.042

1.931

1.084 (1.002, 1.183)

0.054

Erythrocyte

0.787

0.543

1.449

2.196 (0.759, 6.471)

0.147

Hemoglobin

-0.025

0.018

-1.414

0.975 (0.941, 1.010)

0.157

SA

0.049

0.024

2.049

1.050 (1.002, 1.100)

0.04

CYFRA21-1

0.209

0.158

1.321

1.232 (0.911, 1.705)

0.186

CEA

0.094

0.112

0.84

1.099 (0.877, 1.366)

0.401

Gender

  Female

Ref.

    

  Male

0.768

0.47

1.633

2.154 (0.859, 5.458)

0.103

Smoking history

  Non-smoker

Ref.

    

  Smoker

-0.327

0.435

-0.751

0.721 (0.304, 1.685)

0.453

Blood type

  A

Ref.

    

  B

0.582

0.368

1.582

1.790 (0.875, 3.722)

0.114

  AB

0.857

0.49

1.749

2.356 (0.898, 6.187)

0.08

  O

-0.278

0.386

-0.72

0.757 (0.352, 1.609)

0.472

ASA

  1

Ref.

    

  2

-0.855

0.526

-1.625

0.425 (0.153, 1.222)

0.104

  3

0.345

1.586

0.218

1.412 (0.045, 46.131)

0.828

Location

  Centrality

Ref.

    

  Peripherality

-1.245

0.515

-2.418

0.288 (0.104, 0.794)

0.016

Shape

  Regularity

Ref.

    

  Irregularity

0.444

0.327

1.358

1.559 (0.819, 2.962)

0.174

Spiculation

  No

Ref.

    

  Yes

0.253

0.309

0.819

1.288 (0.699, 2.360)

0.413

Vascular penetration sign

  No

Ref.

    

  Yes

-0.601

0.346

-1.736

0.549 (0.275, 1.074)

0.083

Pleural adhesions

  No

Ref.

    

  Yes

0.935

0.308

3.034

2.548 (1.398, 4.700)

0.002

Bronchus sign

  No

Ref.

    

  Yes

0.979

0.373

2.625

2.662 (1.286, 5.576)

0.009

Lobulation

  No

Ref.

    

  Yes

0.815

0.38

2.147

2.260 (1.078, 4.799)

0.032

  1. IAC Invasive adenocarcinoma, COPD Chronic obstructive pulmonary diseases, ASA American Society of Anesthesiologists, PNI Prognostic nutritional index,  NLR Neutrophil-lymphocyte ratio, PLR Platelet-lymphocyte ratio, MLR Monocyte-lymphocyte ratio, dNLR derived neutrophil-to-lymphocyte ratio, NLPR Neutrophil to lymphocyte and platelet ratio, SIRI Systemic inflammatory response syndrome, AISI Aggregate index of systemic inflammation, SII Systemic inflammation index, PIV Pan-immune-inflammation value, LDH Lactate dehydrogenase, SA Serum amyloid, 5'-NT 5'-nucleotidase, Pro-GRP Pro-gastrin-releasing peptide, SCC Squamous cell carcinoma, Cyfra21-1 Cytokeratin 19-fragments, CEA Carcinoembryonic antigen, CA125 Carcinoma antigen 125,  NSE Neuron-specific enolase, BMI Body mass index, FEV1 Forced expiratory volume in one second, MVV Maximal voluntary ventilation