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Table 4 Multivariate Cox regression analyses of clinicopathological features associated with OS of patients with PDAC

From: Combined utility of Ki-67 index and tumor grade to stratify patients with pancreatic ductal adenocarcinoma who underwent upfront surgery

 

Developing cohort

Validation cohort

HR (95% CI)

P

HR (95% CI)

P

TNM stage

 

< 0.001

 

< 0.001

 II vs. I

3.781 (2.844–5.025)

< 0.001

3.580 (2.481–5.165)

< 0.001

 III vs. I

7.476 (5.481–10.20)

< 0.001

5.928 (3.968–8.857)

< 0.001

G-ki67

 

< 0.001

 

< 0.001

 II vs. I

1.299 (1.038–1.624)

0.022

1.374(1.011–1.867)

0.042

 III vs. I

1.942 (1.477–2.554)

< 0.001

2.756 (1.920–3.956)

< 0.001

Adjuvant therapy, without vs. with

2.788 (2.275–3.416)

< 0.001

2.232 (1.703–2.924)

< 0.001

  1. Abbreviations: CI Confidence interval, HR Hazard ratio, TNM Tumor–node–metastasis