Table 2 Clinicopathological factors associated with OS in ICC patients

Age (≧65)

0.304

0.219

Gender (male)

0.441

0.398

HBsAg positive

0.112

0.098

Child-Pugh Class (A/B)

0.821

0.809

AST≧31 IU/L

< 0.001

0.055

CA-199≧36.2 U/mL

0.001

1.571 (1.119–2.207)

0.009

Tumor diameter ≧5 cm

< 0.001

1.849 (1.260–2.713)

0.002

Multifocal lesions

< 0.001

1.500 (1.067–2.108)

0.020

Major hepatectomy

0.389

0.989

Lymphadenectomy

0.432

0.504 (0.298–0.853)

0.011

Tumor differentiation (Poor)

0.003

0.226

Macrovascular invasion

0.002

0.052

Microvascular invasion

< 0.001

1.569 (1.038–2.370)

0.032

Perineural invasion

0.004

0.056

Periductal invasion

0.071

2.899 (1.154–7.281)

0.024

Margin positive

0.202

2.142 (1.030–4.454)

0.042

Lymph node metastasis

< 0.001

3.682 (1.949–6.957)

< 0.001

Pathological cirrhosis

0.06

0.072

Antiviral therapy

0474

0.869

Adjuvant therapy

0.345

0.683 (0.484–0.963)

0.030