Table 4 Univariate and multivariate Cox-regression analyses for predicting cancer-specific survival (CSS) after PSM.

Age

Elderly vs. Nonelderly

1.02 (0.81–1.29)

0.873

Male sex

male vs. female

1.09 (0.8–1.48)

0.577

ASA score

> 2 vs. ≤ 2

0.86 (0.64–1.14)

0.293

Overweight

Yes vs. No

0.83 (0.63–1.08)

0.168

Comorbidity

Yes vs. No

0.99 (0.76–1.28)

0.915

Preoperative AFP level

> 400 ug/L vs. ≤ 400 ug/L

1.68 (1.31–2.16)

< 0.001

1.36 (1.05, 1.77)

0.020

Preoperative ALT level

> 40 U/L vs. ≤ 40 U/L

0.94 (0.74–1.21)

0.380

Preoperative AST level

> 40 U/L vs. ≤ 40 U/L

1.42 (1.13–1.8)

0.030

1.25 (0.97, 1.61)

0.083

HBV infection

Yes vs. No

1.16 (0.82–1.64)

0.390

Cirrhosis

Yes vs. No

1.54 (1.22–1.95)

< 0.001

1.34 (1.03, 1.74)

0.030

Portal hypertension

Yes vs. No

1.15 (0.89–1.47)

0.284

Child‒Pugh grade

B vs. A

1.88 (1.12–3.17)

0.018

1.92 (1.12, 3.29)

0.018

BCLC staging

B/C vs. A

2.33 (1.82–2.97)

< 0.001

1.14 (0.91–1.57)

0.107

Open hepatectomy

Yes vs. No

0.64 (0.45–0.91)

0.014

0.71 (0.49, 1.04)

0.075

Margin width

< 1 cm vs. ≥ 1 cm

1.00 (0.73–1.38)

0.982

Blood loss

> 600ml vs. ≤ 600ml

1.57 (1.08–2.27)

0.018

1.30 (0.88, 1.92)

0.181

Intraoperative blood transfusion

Yes vs. No

1.7 (1.31–2.21)

< 0.001

1.14 (0.85, 1.52)

0.374

Operation duration

> 180 min vs. ≤ 180 min

1.17 (0.91–1.51)

0.227

Anatomical hepatectomy

Yes vs. No

1.26 (1-1.6)

0.052

1.32 (0.78, 1.68)

0.067

Extended hemihepatectomy

Yes vs. No

1.43 (1.06–1.93)

0.019

1.00 (0.73, 1.36)

0.978

Occlusion

Yes vs. No

1.22 (0.96–1.55)

0.099

1.05 (0.81, 1.36)

0.721

Macrovascular invasion

Yes vs. No

2.70 (1.76–4.14)

< 0.001

2.00 (1.25, 3.21)

0.004

MVI

Yes vs. No

1.73 (1.34–2.21)

< 0.001

1.20 (1.03, 1.58)

0.034

Satellite nodules

Yes vs. No

2.7 (1.9–3.85)

< 0.001

2.48 (1.72, 3.57)

< 0.001

Poor Tumor differentiation

Yes vs. No

0.92 (0.71–1.21)

0.559

Incomplete tumor envelope

Yes vs. No

1.53 (1.07–2.19)

0.019

1.42 (0.97, 2.07)

0.071

Tumor diameter

> 5 cm vs. ≤ 5 cm

2.07 (1.63–2.63)

< 0.001

1.67 (1.28, 2.19)

< 0.001