The impact of sarcopenia on esophagectomy for cancer: a systematic review and meta-analysis

Park, Amanda; Orlandini, Marina Feliciano; Szor, Daniel José; Junior, Ulysses Ribeiro; Tustumi, Francisco

doi:10.1186/s12893-023-02149-6

BMC Surgery

Table 1 Baseline characteristics of the included studies. MIE: Minimally invasive esophagectomy; VATS: Video-assisted thoracoscopic surgery; SCC: Squamous cell carcinoma; CRT: Chemoradiotherapy; R: Retrospective; P: Prospective; NI: Not informed; SMM: Skeletal muscle mass; SMI: Skeletal muscle mass index; BMI: Body mass index; PMI: Psoas muscle index; MMI: Masseter mass index; BIA: Bioelectrical impedance analysis; HGS: Hand grip strength; CT: Computed tomography; TPA: Total psoas area

From: The impact of sarcopenia on esophagectomy for cancer: a systematic review and meta-analysis

Author - year	N	Age (years)	Design	Male	Follow-up	MIE, hybrid, or VATS	SCC	Neoadj. CRT	Stage III/IV	Method	Sarcopenia definition
											Men	Women
NAMBARA M − 2021	73	65.3	R	0.53	NI	0.88	NI	0.68	0.52	BIA	SMM < 90%
FEHRENBACH U − 2021	85	64.3	R	0.88	24	0.91	0	0.21	0.67	CT L3	SMI ≤ 52.4 cm²/m²	SMI ≤ 38.5 cm²/m²
UEMURA S − 2021	121	65	R	0.83	36	0.99	NI	0.3	NI	CT L3	PMI < 6 cm²/m², BMI < 18.5 kg/m²
WAKEFILED CJ − 2021	52	65	R	0.87	24.9	0.23	0.17	NI	0.15	CT L3	SMI: < 43 cm²/m² (BMI < 25), 53 cm²/m² (BMI ≥ 25)	SMI < 41 cm²/m²
MAYANAGI S − 2020	187	62.8	R	0.8	0.5	0.87	0.90	0.43	0.36	CT L3	PMI < 6.36 cm²/m²	PMI < 3.92 cm²/m²
WANG PY − 2020	152	64.6	P	0.67	3	1	0.93	0.40	0.61	NI	Low appendicular skeletal muscle mass index < 7 kg/m²	Low appendicular skeletal muscle mass index < 5.7 kg/m²
MAEDA N − 2020	72	66	R	0.9	NI	0.69	1	0.01	0.5	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
SAKAI M − 2021	89	64.1	R	0.87	60	NI	0.93	0	0.48	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
KAWAKITA Y − 2020	113	64.2	R	0.85	3	1	1	1	NI	CT L3	PMI < 3.85 cm²/m²	PMI < 2.42 cm²/m²
SRPCIC M − 2020	139	63.9	P	0.84	18.1	0.37	0.46	0.53	0.44	CT L3	SMI < 43.1 cm²/m²	SMI < 32.7 cm²/m²
MENEZES TM − 2020	26	58	P	0.65	NI	0.69	NI	1	0.42	CT L3	MMI 43 cm²/m² (BMI < 25), 53 cm²/m² (BMI ≥ 25). PTA < 545 mm²/m²	MMI 41 cm²/m². PTA < 285 mm²/m²
ISHIDA T − 2019	165	65.9	R	0.87	NI	0.25	NI	1	0.70	CT L3	PMI < 6.36 cm2/m²	PMI < 3.92 cm²/m²
KAMITANI N − 2019	90	66.2	R	0.86	20.8	NI	1	1	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
OGUMA J − 2019	194	64	R	0.88	38	0.27	1	0	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
XU J − 2019	141	59.6	R	0.79	12	1	1	0	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
YASSAIE SS − 2019	53	64.5	R	0.92	NI	0	1	1	0.49	CT L4	> 4% loss of TPA
SOMA D − 2019	102	68	R	0.87	NI	0.63	1	0.24	0.58	CT L3	SMI < 43 cm²/m² (BMI < 25 kg/m²), < 53 cm²/m² (BMI > 25 kg/m²)	SMI < 41cm²/m²
MATSUNAGA T − 2019	163	65	R	0.78	27	NI	0.94	0.07	0.36	NI	SMM < lower limit of standard SMM (< 90% of the standard)
NAGATA K − 2018	123	70	R	0.85	60	0.67	1	NI	0.39	CT L3	PMI < 4.24 cm²/m²	PMI < 2.50 cm²/m²
NAKASHIMA Y − 2018	341	NI	R	0.85	60	NI	0.95	0.52	0.47	CT L3	SMI < 47.24 cm²/m²	SMI < 36.92 cm²/m²
JARVINEN T − 2018	115	63	R	0.75	24	0.77	0.23	1	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
MAKIURA D − 2018	98	65.6	R	0.85	24	0.93	NI	0.72	0.49	NI	Low muscle mass (< 7.0 kg/m²) plus low muscle strength (< 26 kg) and/or low physical performance (< 0.8 m/s)	Low muscle mass (< 5.7 kg/m²) plus low muscle strength (< 18 kg) and/or low physical performance (< 0.8 m/s)
ELLIOTT JA − 2017	192	61.6	P	0.82	26	NI	0.20	1	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
KUDOU K − 2017	148	64.9	R	0.72	60	0.06	0	NI	NI	CT L3	SMI < 43 cm²/m² (BMI < 25 kg/m²), < 53 cm²/m² (BMI > 25 kg/m²)	SMI < 41 cm²/m²
PAIREDER M − 2017	130	62.8	R	0.82	21.2	NI	0.33	0.05	NI	CT L3	SMI ≤ 55 cm²/m²	SMI ≤ 39 cm²/m²
GROTENHUIS BA − 2016	120	61.8	R	0.74	20	0	0.26	1	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
MAKIURA D − 2016	104	65.4	R	0.85	NI	NI	0.94	0.78	0.44	BIA + HGS	Low muscle mass (< 7.0 kg/m²) plus low muscle strength (< 26 kg) and/or low physical performance (< 0.8 m/s)	Low muscle mass (< 5,7 kg/m²) plus low muscle strength (< 18 kg) and/or low physical performance (< 0.8 m/s)
NISHIGORI T − 2016	199	65.3	R	0.82	NI	0.94	1	0.58	0.34	CT L3	SMI < 52.4cm²/m²	SMI < 38.5 cm²/m²
TAMANDL D − 2016	200	64	R	0.75	35.1	NI	0.3	0.65	NI	CT L3	SMI ≤ 55cm²/m²	SMI ≤ 39 cm²/m²
HARADA K − 2016	256	NI	R	0.92	49.6	0.05	1	0.41	0.59	CT L3	SMI < 44.5 cm²/m²	SMI < 36.5 cm²/m²
IDA S − 2015	138	65.2	P	0.88	NI	NI	1	0.11	0.25	BIA	SMM < 90% of the standard
PANJE CM − 2019	60	61	R	0.93	48	NI	0.18	1	0.72	CT L3	SMI < 43 cm²/m² (BMI < 25 kg/m²), < 53 cm²/m² (BMI > 25 kg/m²)	SMI < 41cm²/m²
SIEGAL SR − 2018	173	65.6	R	0.83	27.6	0.95	0.12	0.83	0.47	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
SAEKI H − 2018	157	64	R	0.82	60	NI	1	0.53	0.76	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
MURNANE LC- 2021	108	66	R	0.75	NI	NI	0.11	0.21	NI	CT L3	SMI < 52.4 cm²/m²	SMI < 38.5 cm²/m²
COLCORD ME- 2021	175	67	R	0.86	12	1	0.13	0.84	NI	Hand-grip	< 26 kg	< 16 kg
KAMADA T − 2022	70	68	R	0.93	36	1	0.88	0.06	0.4	Masseter	< 24.3 cm²	< 26.2 cm²
WATANABE A − 2022	135	67	R	0.67	NI	1	NI	0.69	0.43	CT L3	Low muscle mass < 7.0 kg/m²	Low muscle mass < 5.7 kg/m²
KURITA D − 2022	247	65	R	0.81	NI	1	0.66	0	0.51	Hand-grip	< 28 kg	< 18 kg
SUGIMURA K − 2022	363	70	R	0.8	33	NI	NI	0.16	0.35	NI	Low muscle mass < 7.0 kg/m²	Low muscle mass < 5.7 kg/m²

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