Table 2 Clinicopathologic characteristics of all patients stratified by neoadjuvant chemotherapy
Characteristics | Neoadjuvant chemotherapy (n = 166) | Without neoadjuvant chemotherapy (n = 182) | P value |
|---|---|---|---|
Age, years | 0.003 | ||
≤ 60 > 60 | 115(69.3) 51(30.7) | 98(53.8) 84(46.2) | |
Gender | 0.187 | ||
Male Female | 116(69.9) 50(30.1) | 115(63.2) 67(36.8) | |
Primary tumor location | 0.199 | ||
Colon Rectum | 99(59.6) 67(40.4) | 121(66.5) 61(33.5) | |
T stage | 0.034 | ||
T1- T3 T4 | 90(54.2) 76(45.8) | 119(65.4) 63(34.6) | |
Nodal metastases | 0.120 | ||
Positive Negative | 70(42.2) 96(57.8) | 62(34.1) 120(65.9) | |
Primary tumor differentiation | 0.462 | ||
Well to moderate Poor | 123(74.1) 43(25.9) | 141(77.5) 41(22.5) | |
Timing of metastasis | < 0.001 | ||
Synchronous Metachronous | 130(78.3) 36(21.7) | 109(59.9) 73(40.1) | |
Preoperative CEA (ng/ml)a | 0.251 | ||
≤ 5 > 5 | 68(43) 90(57) | 63(43) 108(57) | |
Preoperative CA19-9 (U/ml)b | 0.145 | ||
≤ 35 > 35 | 111(73) 43(27) | 110(65.5) 58(31.9) | |
Number of CRLM | < 0.001 | ||
1 > 1 | 47(28.3) 119(71.7) | 125(68.7) 57(31.3) | |
Size of largest CRLM (cm) | 0.063 | ||
≤ 3 > 3 | 104(62.7) 62(37.3) | 131(72) 51(28) | |
TBS | < 0.001 | ||
≤ 3 > 3 | 48(28.9) 118(71.1) | 106(58.2) 76(41.8) | |
Tumor distribution | < 0.001 | ||
Unilobar Bilobar | 91(54.8) 75(45.2) | 154(84.6) 28(15.4) | |
Postoperative chemotherapy | 0.032 | ||
Yes No | 126(75.9) 40(24.1) | 119(65.4) 63(34.6) |