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Table 4 Recently reported studies in predicting risk factors and protective factors for DGE

From: Risk stratification of clinically relevant delayed gastric emptying after pancreaticoduodenectomy

Author, year

Country

Type

Research period

Sample size

Outcome variable

Risk factors

Protective factors

Herrera, 2019 [19]

Spain

RCT

2013–2016

64

Grade A-C

Male gender, Intro-abdominal complications, Preoperative malnutrition, Hemorrhage

NA

Watanabe, 2020 [20]

Japan

Retrospective

2009–2018

281

Grade B-C

POPF, TACC > 110 mm

NA

Cai, 2020 [2]

China

Retrospective

2009–2018

308

Grade B-C

PPPD, Biliary leakage, Intra-abdominal infection, Diabetes

NA

Lee, 2020 [21]

South Korea

Retrospective

2010–2016

115

Grade A-C

PPPD, POPF grade B-C

NA

Snyder, 2020 [22]

USA

ACS-NSQIP

database

2014–2016

10,249

Grade B-C

Age > 65 years, Male sex, BMI > 30, ASA ≥ 3, PPPD, Longer operative time (> 356 min)

Preoperative chemotherapy

Quero, 2021 [23]

Italy

Prospective

2019–2020

121

Grade B-C

ASA ≥ 3, Horizontal gastrojejunostomy orientation, Flow angle > 30° (Efferent jejunal limb and the stomach), Clavien-Dindo complications ≥ 3

NA

Varghese, 2021 [24]

New Zealand

Meta-Analysis

on 24 RCTs

1999- 2020

2526

Grade B-C

PPPD

Antecolic gastrojejunostomy, Braun’s anastomosis

Arango, 2021 [18]

USA

Prospective

2011–2019

724

Grade A-C

PPPD, Intra-abdominal abscess, Non-white patient

Implementation of RSPCPs

Fahlbusch, 2022 [25]

Germany

StuDoQ|Pancreas database

2014–2018

5,080

Grade A-C

Higher age, Longer operative time, Pancreaticogastrostomy, POPF

NA

Werba 2022 [1]

USA

ACS-NSQIP

database

2014–2018

15,154

Grade B-C

Age > 70 years, COPD, Smoker, ASA ≥ 3, Male sex and Preoperative RBC transfusion, PPPD, Pancreaticogastrostomy, Adhesiolysis, Jejunostomy, Vascular reconstruction

Biliary stent placement, Active smoking

  1. POPF postoperative pancreatic fistula, TACC thickness of the abdominal cavity at the level of the celiac axis, PPPD pylorus—preserving pancreaticoduodenectomy, BMI body mass index, RSPCPs risk-stratified pancreatectomy clinical pathways, COPD chronic obstructive pulmonary disease, RBC red blood cell, RCT randomized controlled trial