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Table 1 Characteristics of included systematic reviews

From: An umbrella review of the surgical performance of Harmonic ultrasonic devices and impact on patient outcomes

Review

No. of RCTs

No. of patients

Comparator

Surgical Procedure

Outcomes Reported

GRADE rating

Colectomy

 Tou, 2011 [15]

6

417

Conventional and ABP

Laparoscopic Colectomy

Operating time, length of stay, conversion to alternative technique, postoperative blood loss, overall complications, total cost

Low to Moderate

Hemorrhoidectomy

 Mushaya, 2014 [17]

8

468

Conventional

Hemorrhoidectomy

Operating time, length of stay, pain, time to return to work, overall complications

Low to High

 Balciscueta, 2021 [18]

4

278

Conventional

Hemorrhoidectomy (grade III-IV)

Pain

Low

Gastrectomy

 Chen, 2014 [19]

7a

1930

Conventional

Open gastrectomy for gastric cancer

Operating time, length of stay, drainage volume, intraoperative blood loss, transfusion, overall complications, number of lymph nodes dissected

Moderate

 Cheng, 2015 [20]

10

935

Conventional

Gastrectomy and D2 Lymphadenectomy for Gastric Cancer

Operating time, length of stay, drainage volume, intraoperative blood loss, postoperative death, hospital costs

Low to Moderate

 Sun, 2015 [21]

5

489

Conventional

Open gastrectomy for gastric cancer

Operating time, length of stay, drainage volume, transfusion, hemorrhage, overall complications

Low to Moderate

Mastectomy

 Cheng, 2016 [22]

12

965

Conventional

Mastectomy and BCS with LND

Operating time, length of stay, drainage volume, intraoperative blood loss, hematoma, seroma, overall complication, wound infection

Low to Moderate

 Zhang, 2018 [23]

10b

NR

Conventional

Mastectomy and BCS with LND

Operating time, length of stay, drainage volume, drain time, intraoperative blood loss, hematoma, seroma, overall complication, wound infection, other complications

Low to Moderate

Flap Harvesting

 Kim, 2022 [24]

8

505

Conventional

Flap surgery for various flap types

Operating time, drainage volume, Intraoperative blood loss, hematoma, wound infection, additional complication, overall complication

Low to Moderate

Cholecystectomy

 Sasi, 2010 [25]

7

695

Conventional

Laparoscopic Cholecystectomy

Operating time, length of stay, conversion to alternative technique, pain, time to return to work, overall complications, bile leak, gallbladder perforation

Low to High

 Xiong, 2012 [26]

11

1434

Conventional

Laparoscopic Cholecystectomy

Operating time, length of stay, conversion to an alternative technique, pain, intraoperative bleeding, nausea/vomiting, other complications, bile leak, gallbladder perforation

Low to High

 Jiang, 2017 [27]

19

1955

Conventional

Laparoscopic Cholecystectomy

Operating time, length of stay, pain, intraoperative blood loss, gallbladder perforation

Low to Moderate

Thyroidectomy

 Cirocchi, 2010 [28]

7

608

Conventional

Total thyroidectomy

Operating time, drainage volume, intraoperative blood loss, vocal cord and RLN palsy/paralysis—temp, vocal cord and RLN palsy/paralysis—perm, hypocalcemia

Moderate

 Ecker, 2010 [29]

10

485

Conventional and ABP

Total, hemi-, and subtotal thyroidectomy

Operating time, length of stay, drainage volume, pain, intraoperative blood loss, overall complications

Very Low to Low

 Melck, 2010 [30]

9

822

Conventional

Total and subtotal thyroidectomy

Operating time, vocal cord and RLN palsy/paralysis—temp, hypocalcemia

Moderate

 Cheng, 2015 [31]

14

2516

Conventional

Total thyroidectomy

Operating time, length of stay, drainage volume, pain, intraoperative blood loss, hematoma, seroma, vocal cord and RLN palsy/paralysis—temp, hypocalcemia

Low to Moderate

 Cannizzaro, 2016 [16]

17

2596

Conventional and ABP

Total thyroidectomy

Operating time, length of stay, pain, intraoperative blood loss, overall complications

Very Low to Low

 Cheng, 2016 [32]

7

954

Conventional

Total thyroidectomy

Total costs

NA

 Revelli, 2016 [33]

21

3125

Conventional

Total thyroidectomy

Operating time, length of stay, drain placed, pain, intraoperative blood loss, additional wound complications, vocal cord and RLN palsy/paralysis—temp, hypocalcemia

Low to Moderate

 Upadhyaya, 2016 [34]

7

981

ABP

Partial and total thyroidectomy

Operating time, length of stay, intraoperative blood loss, postoperative blood loss, mean thyroid weight, calcium levels

Low to Moderate

 Aires, 2018 [35]

31

NR

Conventional

Total thyroidectomy

Operating time, intraoperative blood loss, hematoma, laryngeal nerve injury, number of lymph nodes removed

Moderate

 Hua, 2019 [36]

23

5408

Conventional

Total thyroidectomy

Hematoma

NA

Tonsillectomy

 Alexiou, 2011 [37]

11c

3139

Conventional

Total tonsillectomy

Operating time, pain, intraoperative blood loss, postoperative blood loss

Very Low to Low

Neck Dissection

 Ren, 2015 [38]

7

406

Conventional

Neck dissection

Operating time, length of stay, drainage volume, intraoperative blood loss

Low to Moderate

  1. For specific details of GRADE assessments refer to Supplementary Table 5
  2. Abbreviations: ABP advanced bipolar, BCS breast conserving surgery, GRADE Grades of Recommendation, Assessment, Development and Evaluation, LND lymph node dissection, RCT randomized controlled trial, RLN recurrent laryngeal nerve
  3. aChen, 2014 included 19 studies (7 RCTs and 12 non-RCTs). Outcomes were stratified by study design and only data from RCTs were included in this review
  4. bZhang, 2018 included 20 studies (10 RCTs and 10 non-RCTs). Outcomes were stratified by study design and only data from RCTs were included in this review
  5. cAlexiou, 2011 included 33 RCTs comparing various methods of tonsillectomy. Of these, 11 compared Harmonic devices to conventional techniques and were included in this review