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Table 1 Correlations between liver-to-spleen signal intensity ratio increasing rate (LSRi) and clinical factors

From: Liver functional assessment using time-associated change in the liver-to-spleen signal intensity ratio on enhanced magnetic resonance imaging: a retrospective study

   

LSR (15 min)

P

 

LSRi

P

Age (years)

≥ 70 (n = 146)

 

2.05 [1.10–2.83]

0.414

 

0.327 [0.049–0.517]

0.847

 

< 70 (n = 133)

 

2.03 [0.99–2.77]

  

0.326 [0.060–0.566]

 

Sex

Male (n = 156)

 

2.08 [1.10–2.83]

0.700

 

0.329 [0.049–0.544]

0.983

 

Female (n = 123)

 

2.03 [0.99–2.77]

  

0.324 [0.059–0.566]

 

Hypertension

Yes (n = 126)

 

1.99 [0.99–2.83]

0.074

 

0.319 [0.049–0.513]

0.093

 

No (n = 153)

 

2.08 [1.19–2.77]

  

0.334 [0.052–0.566]

 

Diabetes

Yes (n = 95)

 

2.00 [0.99–2.83]

0.387

 

0.319 [0.059–0.517]

0.209

 

No (n = 184)

 

2.08 [1.19–2.77]

  

0.332 [0.049–0.566]

 

Dyslipidemia

Yes (n = 81)

 

2.04 [0.99–2.83]

0.739

 

0.329 [0.060–0.513]

0.571

 

No (n = 198)

 

2.04 [1.11–2.77]

  

0.325 [0.049–0.566]

 

Viral hepatitis

Yes (n = 12)

 

2.03 [1.53–2.60]

0.547

 

0.304 [0.195–0.499]

0.586

 

No (n = 267)

 

2.05 [0.99–2.83]

  

0.327 [0.049–0.566]

 

Previous chemotherapy

Yes (n = 39)

 

1.99 [1.48–2.83]

0.541

 

0.319 [0.168–0.513]

0.571

 

No (n = 240)

 

2.05 [0.99–2.77]

  

0.329 [0.049–0.566]

 

Fatty liver

Yes (n = 28)

 

1.76 [1.27–2.42]

< 0.001*

 

0.248 [0.049–0.467]

< 0.001*

 

No (n = 251)

 

2.08 [0.99–2.83]

  

0.332 [0.052–0.566]

 

MRI equipment

Achieva (n = 166)

 

2.06 [0.99–2.83]

0.198

 

0.331 [0.049–0.566]

0.267

 

Ingenia (n = 113)

 

2.02 [1.11–2.76]

  

0.323 [0.052–0.544]

 

Slice thickness (mm)

≥ 4.8 (n = 92)

 

1.99 [1.10–2.83]

0.539

 

0.324 [0.049–0.513]

0.639

 

< 4.8 (n = 187)

 

2.05 [0.99–2.68]

  

0.330 [0.058–0.566]

 

Child-Pugh grade

A (n = 238)

 

2.09 [0.99–2.77]

< 0.001*

 

0.341 [0.129–0.566]

< 0.001*

 

B or C (n = 41)

 

1.43 [1.10–2.83]

  

0.114 [0.049–0.513]

 

ALBI grade

1 (n = 188)

 

2.11 [1.51–2.77]

< 0.001*

 

0.355 [0.168–0.566]

< 0.001*

 

2 or 3 (n = 91)

 

1.79 [0.99–2.83]

  

0.254 [0.049–0.513]

 

Platelet count (×10 4 /µL)

≥ 15.8 (n = 245)

 

2.04 [1.10–2.83]

0.360

 

0.324 [0.049–0.566]

0.102

 

< 15.8 (n = 34)

 

2.06 [0.99–2.76]

  

0.356 [0.138–0.512]

 

Albumin (g/dL)

≥ 4.1 (n = 180)

 

2.09 [1.30–2.77]

< 0.001*

 

0.352 [0.074–0.566]

< 0.001*

 

< 4.1 (n = 99)

 

1.90 [0.99–2.83]

  

0.296 [0.049–0.513]

 

Total bilirubin (mg/dL)

≥ 1.5 (n = 51)

 

1.50 [1.10–2.56]

< 0.001*

 

0.150 [0.049–0.451]

< 0.001*

 

< 1.5 (n = 228)

 

2.09 [0.99–2.83]

  

0.345 [0.129–0.566]

 

Prothrombin time (%)

≥ 70 (n = 268)

 

2.06 [1.10–2.83]

< 0.001*

 

0.329 [0.052–0.566]

< 0.001*

 

< 70 (n = 11)

 

1.44 [0.99–2.09]

  

0.138 [0.049–0.385]

 
  1. ALBI grade, albumin-bilirubin grade; LSR, liver-to-spleen signal intensity ratio; LSRi, liver-to-spleen signal intensity ratio increasing rate; MRI, magnetic resonance imaging
  2. * P < 0.05; continuous variables were analyzed using the Mann-Whitney test, and are presented as median and range
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