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Table 3 The risk factors for a postoperative prolonged hospital stay

From: Enhanced recovery after surgery in primary liver cancer patients undergoing hepatectomy: experience from a large tertiary hospital in China

 

Postoperative hospitalization days of > 6 days

Risk factors of postoperative hospitalization days > 6 days

    

univariable

multivariable-1

multivariable-2

Variables

No (N = 199)

Yes (N = 119)

P

OR (95%CI)

OR (95%CI)

OR (95%CI)

Group

  

< 0.001

   

ERAS

110 (55.3%)

40 (33.6%)

 

1 reference

1 reference

1 reference

Non-ERAS

89 (44.7%)

79 (66.4%)

 

2.44 (1.52–3.91, p < .001)

2.63 (1.57–4.43, p < .001)

2.64 (1.59–4.38, p < .001)

Age at diagnosis

54.8 (11.1)

55.2 (9.46)

0.726

1.00 (0.98–1.03, p = .735)

  

Sex

  

0.689

   

Female

47 (23.6%)

25 (21.0%)

 

1 reference

  

Male

152 (76.4%)

94 (79.0%)

 

1.16 (0.67–2.01, p = .591)

  

BMI

23.2 [20.9;24.8]

23.0 [20.9;25.5]

0.947

1.00 (0.93–1.08, p = .920)

  

Education level

  

0.903

   

No school/primary education

47 (23.6%)

32 (26.9%)

 

1 reference

  

Middle Education

66 (33.2%)

40 (33.6%)

 

0.89 (0.49–1.62, p = .702)

  

High education

44 (22.1%)

24 (20.2%)

 

0.80 (0.41–1.57, p = .517)

  

University education

42 (21.1%)

23 (19.3%)

 

0.80 (0.41–1.59, p = .529)

  

Comorbidity

  

0.91

   

No

170 (85.4%)

103 (86.6%)

 

1 reference

  

Yes

29 (14.6%)

16 (13.4%)

 

0.91 (0.47–1.76, p = .780)

  

Chronic smoking

  

1

   

No

150 (75.4%)

89 (74.8%)

 

1 reference

  

Yes

49 (24.6%)

30 (25.2%)

 

1.03 (0.61–1.74, p = .907)

  

Chronic drinking

  

0.376

   

No

174 (87.4%)

99 (83.2%)

    

Yes

25 (12.6%)

20 (16.8%)

 

1.41 (0.74–2.66, p = .295)

  

ALT (U/L)

27.0 [20.0;33.0]

25.0 [18.0;33.5]

0.273

0.98 (0.96–1.01, p = .293)

  

AST (U/L)

25.0 [17.0;31.0]

23.0 [18.0;29.0]

0.547

0.99 (0.96–1.02, p = .598)

  

PLT (×109 L)

195 [138;240]

194 [140;242]

0.777

1.00 (1.00–1.00, p = .773)

  

HB (g/L)

137 [125;151]

140 [124;150]

0.828

1.00 (0.99–1.01, p = .815)

  

WB (×109 L)

5.43 [4.32;6.63]

5.23 [4.46;6.67]

0.766

0.97 (0.88–1.07, p = .545)

  

Creatinine (umol/L)

74.0 [63.0;83.0]

73.0 [63.5;81.0]

0.535

0.99 (0.98–1.01, p = .410)

  

ALB (g/L)

41.4 [39.0;43.8]

40.9 [38.7;43.2]

0.639

1.00 (0.95–1.06, p = .858)

  

TBIL (umol/L)

12.0 [8.85;15.9]

11.6 [8.15;16.5]

0.665

1.00 (0.98–1.02, p = .976)

  

ASA:

  

0.939

   

I + II

140 (70.4%)

85 (71.4%)

 

1 reference

  

III

59 (29.6%)

34 (28.6%)

 

0.95 (0.58–1.57, p = .838)

  

Surgical approach

  

0.005

   

Laparoscopic technique

71 (35.7%)

24 (20.2%)

 

1 reference

1 reference

1 reference

Open

128 (64.3%)

95 (79.8%)

 

2.20 (1.29–3.74, p = .004)

2.01 (1.12–3.59, p = .018)

2.01 (1.14–3.56, p = .016)

Extent of operation

  

< 0.001

   

Single segmentectomy

97 (48.7%)

42 (35.3%)

 

1 reference

1 reference

1 reference

Two combined segmentectomies

81 (40.7%)

41 (34.5%)

 

1.17 (0.69–1.97, p = .557)

1.05 (0.61–1.83, p = .858)

1.05 (0.61–1.83, p = .857)

Major hepatectomy

21 (10.6%)

36 (30.3%)

 

3.96 (2.07–7.57, p < .001)

3.48 (1.71–7.08, p < .001)

3.48 (1.73–7.03, p < .001)

Surgical time (minute)

271 [222;330]

270 [210;335]

0.703

1.00 (1.00–1.00, p = .468)

  

Blood volume intraoperative (per 100ml)

200 [100;500]

400 [200;600]

< 0.001

1.12 (1.06–1.19, p < .001)

1.08 (1.01–1.15, p = .016)

1.08 (1.02–1.15, p = .006)

Any postoperative complication

  

< 0.001

   

No

153 (76.9%)

68 (57.1%)

 

1 reference

1 reference

 

Yes

46 (23.1%)

51 (42.9%)

 

2.49 (1.53–4.07, p < .001)

1.01 (0.54–1.89, p = .974)

 
  1. Continuous variables are presented as mean (SD, standard deviation) or median (IQR, interquartile range); the categorical variables are presented as numbers (%)
  2. ERAS, enhanced recovery after surgery; BMI, body mass index; ALT, glutamic pyruvic transaminase; AST, glutamic oxaloacetic transaminase; PLT, platelet; HB, hemoglobin; WB; white blood cell; ALB, albumin; TBIL, total bilirubin; ASA, American Society of Anesthesiologists; OR, odd ratio; CI, confidence interval
  3. Multivariable-1 presents the results of including statistically significant variables in univariate analysis in logistics regression; multivariable-2 present the results of stepwise backward logistic regression