Table 1 Criteria for the definition of second primary lung cancer (SPLC)
Martini and Melamed criteria | Antakli et al. Modifications |
|---|---|
Synchronous SPLC (sSPLC) | A. Different histological conditions |
A. Tumors physically distinct and separate | B. Same histological condition with two or more of the following |
B. Histological type | 1. Anatomical distinct |
1. Different | 2. Associated premalignant lesion |
2. Same, but in different segment, lobe or lung if | 3. No systemic metastases |
a. Origin from carcinoma in situ | 4. No mediastinal spread |
b. No carcinoma in common lymphatics | 5. Different DNA ploidy |
c. No extrapulmonary metastases at the time of diagnosis | Â |
Metachronous SPLC (mSPLC) | Â |
A. Histologically different | Â |
B. Histologically identical, if | Â |
1. Free interval between cancers ≥ 2 years, or |  |
2. Origin from carcinoma in situ | Â |
3. Second cancer in different lobe or lung, but: | Â |
a. No carcinoma in common lymphatics | Â |
b. No extrapulmonary metastases at the time of diagnosis | Â |