Drain fluid and serum amylase concentration ratio is the most reliable indicator for predicting postoperative pancreatic fistula after distal pancreatectomy

Table 2 Comparison of surgical outcomes between patients with and without POPF after distal pancreatectomy

	Patients with POPF (n = 30)	Patients without POPF (n = 92)	p-value
Operative time (min)	285 (174–537)	270 (143–564)	0.12
Blood loss (ml)	190 (10–1910)	260 (0–1840)	0.65
Surgical procedure
Open	24 (80.0)	62 (67.4)	0.19
Laparoscopic	6 (20.0)	30 (32.6)	0.19
Spleen preserving	3 (10.0)	18 (19.6)	0.23
Non spleen preserving	27 (90.0)	74 (80.4)	0.23
Stump closure method			0.81
Stapler	19 (63.3)	56 (60.9)
Hand-sewn	11 (36.7)	36 (39.1)
Pancreas texture			< 0.001^***
Soft	24 (85.7)	37 (46.8)
Hard	4 (14.3)	42 (53.2)
Pancreas thickness (mm)	11 (8–17)	11 (3–24)	0.70
SAC (U/L)
POD1	117 (47–1108)	158 (35–1921)	0.36
POD3	38 (11–223)	50 (15–663)	0.11
DAC (U/L)
POD1	7977 (108–34,076)	1975 (42–61,075)	0.01^*
POD3	1799 (42–16,515)	390 (35–43,873)	< 0.001^***
Drainage volume (ml)^a
POD1	60 (12–355)	56 (2–475)	0.91
POD3	30 (5–205)	31 (3–540)	0.60
DAA (U/day)^b
POD1	235 (11–3748)	115 (1–3237)	0.02^*
POD3	53 (2–1906)	16 (0.1–570)	< 0.001^***
DSACR^c
POD1	34 (0.3–315)	14 (0.3–399)	< 0.01^**
POD3	40 (1–403)	7 (0.7–593)	< 0.001^***
Mortality	2 (6.9)	0 (0.0)	0.06
Postoperative hospital stays (days)	35 (12–121)	12 (7–23)	< 0.001^***

Data are expressed as median (range) or number of patients
POPF Postoperative pancreatic fistula, SAC Serum amylase concentration (U/L), DAC Drain fluid amylase concentration (U/L), DAA Drain fluid amylase amount (U/day), DSACR Drain fluid and serum amylase concentration ratio, POD Postoperative day
^aThe 24 h drainage volume from the morning of POD1 and 3
^bCalculated by multiplying drain fluid amylase concentration and drainage volume
^cCalculated by dividing drain fluid amylase concentration by serum amylase concentration
^*: p < 0.05
^**: p < 0.01
^***: p < 0.001

ISSN: 1471-2482