Table 3 Univariable and multivariable analysis of factors associated with OS

Age

  > 70

Ref

  ≤ 70

1.363

0.710–2.616

Gender

 Male

Ref

 Female

1.183

0.782–1.791

Primary T stage

 1–2

Ref

 3–4

0.651

0.328–1.294

Primary N stage

 N0

Ref

 N1-2

1.384

0.894–2.142

Location tumor

 Colon

Ref

 Rectum

1.091

0.737–1.615

Primary tumor location

 Left

Ref

 Right

1.433

0.896–2.293

Disease free interval

  > 12 month

Ref

  ≤ 12 month

1.419

0.756–2.662

CEA

  ≤ 200

Ref

  > 200

1.448

0.587–3.571

CA199

  > 100

Ref

Ref

  ≤ 100

0.451

0.284–0.718

0.485

0.300–0.785

Tumor size

  ≤ 5 cm

Ref

  > 5 cm

1.196

0.727–1.965

Tumor no

  ≤ 1

Ref

  > 1

0.613

0.328–1.146

Neoadjuvant

 No

Ref

 Yes

0.677

0.457–1.003

Ras status

 Wild

Ref

Ref

 Mutation

0.562

0.383–0.842

0.554

0.372–0.825

Hepatic resection

 Minor

Ref

 Major

1.072

0.841–1.297

CRS

 0–2

Ref

Ref

 3–5

0.486

0.300–0.787

0.594

0.355–0.996

Margin status

 R0

Ref

 R1V

1.074

0.661–1.744

 R1P

2.039

1.155–3.599

Line

 Line = 1

Ref

 Line > 1

1.268

0.831–1.934

Cycles

  ≤ 4

Ref

Ref

  > 4

0.528

0.352–0.790

0.533

0.352–0.808

Response

 PR

Ref

 SD

0.776

0.689–1.227

 PD

0.812

0.542–1.361

Distribution

 Unilobar

Ref

Ref

 Bilobar

0.497

0.307–0.805

0.756

0.445–1.238

Complication

 Minor

Ref

 Major

1.563

0.914–7.407

Adjuvant chemotherapy

 No

Ref

 Yes

1.114

0.689–1.437