Table 2 Univariable and multivariable analysis of the prognostic factors for MVI

All patients

Age (≥ 50 years)

0.525

0.353–0.834

0.001

0.527

0.471–0.807

0.001

Sex (Male)

1.238

1.008–2.149

0.037

PLT (≤ 100 × 10⁹/L)

1.41

0.825–1.554

0.149

Maximal tumor size (≥ 7 cm)

2.203

1.910–3.215

< 0.001

2.005

1.170–2.521

< 0.001

AFP (≥ 400 ng/mL)

3.098

2.302–4.057

< 0.001

2.513

2.193–3.582

< 0.001

Tumor (multiple)

1.539

1.333–2.253

0.005

1.758

1.099–2.258

0.001

NEU (≥ 60%)

1.210

1.009–1.778

0.012

1.252

1.001–1.608

0.024

Patients in early-stage with single tumor

Age (≥ 50 years)

0.550

0.396–0.752

0.031

0.678

0.396–0.885

0.036

Sex (Male)

5.479

0.766–8.492

0.099

PLT (≤ 100 × 10⁹/L)

1.045

0.618–2.431

0.638

AFP (≥ 400 ng/mL)

1.702

1.106–2.164

0.001

1.342

1.110–3.700

0.024

NEU (≥ 60%)

1.371

1.124–1.954

0.046

1.301

1.199–2.812

0.045