Table 1 Characteristics of the selected studies
year | Country | author | study design | Group | N | Neoadjuvant | Tumor location (U/M/L/J/O) | Anastomotic technique (HS/S/O) | Tumor pathology (AC/SC/O) | Anastomotic leakage |
|---|---|---|---|---|---|---|---|---|---|---|
2001 | Switzerland | Schilling et al. [14] | Cohort study | CA | 62 | NA | NA | 0/62/0 | 12/37/13 | 5 |
IA | 33 | NA | NA | 0/33/0 | 30/1/2 | 2 | ||||
2001 | Canada | Blewett et al. [15] | Cohort study | CA | 19 | NA | NA | NA | 11/8/0 | 1 |
IA | 55 | NA | NA | NA | 40/15/0 | 9 | ||||
2003 | Sweden | Walther et al. [16] | RCT | CA | 41 | NA | 3/19/16/0/1 | 41/0/0 | 14/25/2 | 1 |
IA | 42 | NA | 1/10/24/0/0 | 0/42/0 | 18/17/7 | 0 | ||||
2006 | Yemen | Homesh et al. [17] | Cohort study | CA | 43 | NA | 6/2/34/1/0 | NA | 24/19/0 | 9 |
IA | 41 | NA | 3/16/18/4/0 | NA | 23/18/0 | 5 | ||||
2007 | Japan | Okuyama et al. [18] | RCT | CA | 18 | NA | 0/13/5/0/0 | 18/0/0 | 0/17/1 | 3 |
IA | 14 | NA | 0/10/4/0/0 | 0/14/0 | 0/13/1 | 1 | ||||
2008 | Germany | Egberts et al. [19] | Cohort study | CA | 33 | 15 | NA | NA | 3/29/1 | 11 |
IA | 72 | 29 | NA | NA | 41/25/6 | 13 | ||||
2011 | India | Kawoosa et al. [20] | Cohort study | CA | 205 | NA | 0/91/71/33/10 | NA | 91/98/16 | 23 |
IA | 177 | NA | 0/81/67/23/6 | NA | 58/105/14 | 5 | ||||
2012 | Germany | Klink et al. [21] | Cohort study | CA | 36 | NA | NA | 36/0/0 | 26/10/0 | 11 |
IA | 36 | NA | NA | 0/36/0 | 29/7/0 | 4 | ||||
2015 | China | Zhai et al. [22] | Cohort study | CA | 40 | NA | 0/23/17/0/0 | 0/40/0 | 6/32/2 | 12 |
IA | 32 | NA | 0/15/17/0/0 | 0/32/0 | 5/26/1 | 3 | ||||
2015 | China | Huang et al. [23] | Cohort study | CA | 114 | NA | 0/114/0/0/0 | 0/114/0 | 0/114/0 | 10 |
IA | 91 | NA | 0/91/0/0/0 | 0/91/0 | 0/91/0 | 2 | ||||
2016 | Netherlands | Workum et al. [24] | Cohort study | CA | 146 | 137 | 0/0/106/40/0 | 123/5/18 | 120/23/3 | 43 |
IA | 210 | 201 | 0/0/172/38/0 | 6/204/0 | 189/19/2 | 43 | ||||
2017 | China | Liu et al. [25] | Cohort study | CA | 126 | 62 | 0/0/37/89/0 | 45/32/49 | 90/28/2 | 21 |
IA | 332 | 176 | 0/0/64/268/0 | 33/201/98 | 249/77/6 | 34 | ||||
2018 | Netherlands | Gooszen et al. [26] | Cohort study | CA | 654 | 600 | 0/47/607/0/0 | NA | 533/104/17 | 143 |
IA | 654 | 604 | 0/42/612/0/0 | NA | 545/92/17 | 111 | ||||
2018 | China | Shao et al. [27] | Cohort study | CA | 282 | NA | 25/201/56/0/0 | NA | 0/282/0 | 42 |
IA | 282 | NA | 15/220/47/0/0 | NA | 0/282/0 | 12 | ||||
2019 | Germany | Schroder et al. [28] | Cohort study | CA | 430 | 281 | NA | 175/255/0 | 289/141/0 | 74 |
IA | 536 | 420 | NA | 0/536/0 | 466/70/0 | 85 | ||||
2020 | America | Chidi et al. [29] | Cohort study | CA | 380 | 380 | NA | NA | 280/44/56 | 54 |
IA | 528 | 528 | NA | NA | 369/40/119 | 65 | ||||
2020 | Netherlands | Workum et al. [30] | Cohort study | CA | 210 | 195 | 0/0/194/16/0 | NA | 161/38/11 | 59 |
IA | 210 | 194 | 0/0/192/18/0 | NA | 183/24/3 | 29 | ||||
2020 | Netherlands | Jezerskyte et al. [31] | Cohort study | CA | 89 | 3 | 0/0/75/14/0 | NA | 60/24/4 | 22 |
IA | 115 | 22 | 0/0/98/17/0 | NA | 103/9/3 | 10 | ||||
2021 | Netherlands | Workum et al. [8] | RCT | CA | 123 | 120 | 0/3/106/14/0 | 108/15/0 | 114/7/2 | 42 |
IA | 122 | 120 | 0/6/105/11/0 | 4/118/0 | 105/12/5 | 15 | ||||
2021 | America | Takahashi et al. [32] | Cohort study | CA | 132 | 78 | NA | NA | 107/19/6 | 13 |
IA | 714 | 459 | NA | NA | 611/73/30 | 31 |