Table 4 Univariate and multivariate Cox proportional hazards analyses of clinicopathological factors associated with overall survival

Sex

0.387

 Men

51

45.5

 Women

28

75.5

Age

0.396

 < 60 years

26

64.7

 ≥ 60 years

53

50.0

Histological type

0.871

 Differentiated

36

59.5

 Undifferentiated

43

52.1

cT

0.111

 Non-cT4

16

68.8

 cT4

63

51.5

cN

0.775

 cN0

12

64.8

 cN1–N3

67

53.6

Initial status of stage IV GC

< 0.001

 IR (Category 1)

23

78.3

 0.378

0.173–0.824

0.014

 UR (Category 2–4)

56

44.5

 1

No. of regimens

0.558

 1

67

52.1

 ≥ 2

12

72.7

No. of cycles of chemotherapy

0.098

 < 5

45

56.7

 0.977

0.524–1.821

0.942

 ≥ 5

34

53.4

 1

Type of operative procedure

0.185

 Total gastrectomy

44

50.1

 Other

35

62.2

Complication (Grade ≥ 3)

0.682

 Yes

14

41.7

 No

65

58.3

Residual tumor

< 0.001

 R0

63

61.8

 0.439

0.227–0.847

0.014

 R1/R2

16

31.3

 1

Histological response

0.406

 Grade 0/Grade 1

52

48.4

 Grade 2/Grade 3

22

70.3