Table 4 Prognostic factors in univariate and multivariate analyses
Factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95% CI) | P-value | HR (95% CI) | P-value | |
Sex | ||||
Male | 1 | |||
Female | 1.479 (0.802–2.727) | 0.211 | ||
Age (year) | ||||
< 60 | 1 | |||
≥ 60 | 1.016 (0.580–1.781) | 0.954 | ||
16a2 area | ||||
Negative | 1 | |||
Positive | 1.120 (0.639–1.964) | 0.691 | ||
16b1 area | ||||
Negative | 1 | |||
Positive | 0.913 (0.502–1.660) | 0.765 | ||
Chemotherapy regimens | ||||
Dual drug combination | 1 | |||
Triple drug combination | 1.069 (0.557–2.052) | 0.840 | ||
Tumor location | ||||
Proximal stomach | 1 | |||
Middle stomach | 0.773 (0.320–1.869) | 0.568 | ||
Distal stomach | 0.997 (0.450–2.205) | 0.993 | ||
Total stomach | 0.971 (0.206–4.584) | 0.970 | ||
Borrmann type | ||||
Borrmann I | 1 | |||
Borrmann II | 0.764 (0.293–1.994) | 0.582 | ||
Borrmann III | 1.918 (0.674–5.460) | 0.223 | ||
Borrmann IV | 0.882 (0.255–3.055) | 0.843 | ||
Grade of differentiation | ||||
Poor | 1 | |||
Moderate | 0.586 (0.318–1.079) | 0.086 | ||
Nerve invasion | ||||
Negative | 1 | 1 | ||
Positive | 2.248 (1.269–3.982) | 0.005* | 2.493 (1.400–4.437) | 0.002* |
Excision extension | ||||
Distal gastrectomy | 1 | |||
Total gastrectomy | 1.205 (0.678–2.141) | 0.526 | ||
Lymph node dissection extent | ||||
D2 | 1 | 1 | ||
D2 + PAND | 0.472 (0.259–0.859) | 0.014* | 0.514 (0.269–0.981) | 0.044* |
Reconstruction method | ||||
Roux-en-Y | 1 | |||
Billronth I | 1.184 (0.571–2.458) | 0.650 | ||
Billronth II | 0.766 (0.393–1.493) | 0.434 | ||
Surgery time | ||||
< 180 min | 1 | |||
≥ 180 min | 0.671 (0.382–1.178) | 0.164 | ||
Intraoperative bleeding | ||||
< 200 ml | 1 | |||
≥ 200 ml | 0.829 (0.470–1.461) | 0.516 | ||
Hospitalization time | ||||
< 12 days | 1 | |||
≥ 12 days | 1.162 (0.662–2.038) | 0.601 | ||
Complication | ||||
Negative | 1 | |||
Positive | 1.235 (0.575–2.654) | 0.588 | ||
Lymph node recurrence | ||||
Negative | 1 | 1 | ||
Positive | 2.740 (1.421–5.285) | 0.003* | 2.146 (1.066–4.319) | 0.032* |