Table 2 Univariate and multivariate analyses of clinicopathological parameters for OS
Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
P | HR (95% CL) | P | HR (95% CL) | |
Sex | ||||
Female | – | Reference | ||
Male | 0.903 | 1.074 (0.340–3.389) | NA | NA |
Age | ||||
≤ 45 | – | Reference | ||
> 45 | 0.015 | 4.145 (1.312–13.094) | 0.518 | 1.479 (0.451–4.849) |
Histology | ||||
Typical carcinoids | – | Reference | ||
Atypical carcinoids | 0.237 | 1.865 (0.664–5.240) | NA | NA |
Nodes metastases | ||||
N1 positive, n (%) | – | Reference | ||
N2 positive, n (%) | 0.917 | 0.947 (0.342–2.623) | NA | NA |
Ki-67 | ||||
Ki-67 ≤ 4.5 | – | Reference | ||
Ki-67 > 4.5 | 0.002 | 10.900 (2.358–50.396) | 0.080 | 4.201 (0.843–20.940) |
Chemotherapy | ||||
No | – | Reference | ||
Yes | 0.046 | 3.211 (1.021–10.099) | 0.602 | 1.371 (0.420–4.477) |
Tumor size | ||||
Size ≤ 2.4 cm | – | Reference | ||
Size > 2.4 cm | 0.007 | 16.660 (2.181–127.245) | 0.511 | 2.801 (0.130–60.238) |
EAS syndrome | ||||
No | – | Reference | ||
Yes | 0.004 | 0.052 (0.007–0.399) | 0.038 | 0.104 (0.012–0.885) |