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Table 4 Comparison of accuracy between present nomograms and four conventional staging systems via C-index

From: Novel postoperative nomograms for predicting individual prognoses of hepatitis B-related hepatocellular carcinoma with cirrhosis

Prognostic system RFS OS
C-index 95% CI P1* P2# C-index 95% CI P1* P2#
Training cohort
Present nomogram 0.739 0.709–0.769 < 0.001 1.0 (Ref.) 0.789 0.759–0.819 < 0.001 1.0 (Ref.)
BCLC 0.615 0.587–0.643 < 0.001 < 0.001 0.633 0.601–0.665 < 0.001 < 0.001
AJCC8th 0.547 0.522–0.572 < 0.001 < 0.001 0.541 0.513–0.569 0.006 < 0.001
JIS score 0.541 0.517–0.566 0.001 < 0.001 0.524 0.497–0.551 0.09 < 0.001
HKLC 0.595 0.566–0.624 < 0.001 < 0.001 0.612 0.578–0.646 < 0.001 < 0.001
Validation cohort
Present nomogram 0.752 0.712–0.792 < 0.001 1.0 (Ref.) 0.813 0.775–0.851 < 0.001 1.0 (Ref.)
BCLC 0.615 0.583–0.647 < 0.001 < 0.001 0.636 0.589–0.683 < 0.001 < 0.001
AJCC8th 0.562 0.527–0.597 < 0.001 < 0.001 0.576 0.535–0.617 < 0.001 < 0.001
JIS score 0.554 0.521–0.587 0.002 < 0.001 0.565 0.524–0.606 0.002 < 0.001
HKLC 0.601 0.559–0.643 < 0.001 < 0.001 0.616 0.567–0.665 < 0.001 < 0.001
  1. Ref. reference; RFS, recurrence-free survival; OS, overall survival; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer staging system; AJCC8th, the eighth version of American Joint Committee on Cancer; JIS score, the Japan Integrated Staging Score; HKLC, the Hong Kong Liver Cancer prognostic classification scheme
  2. *Represent significance of staging systems;
  3. #Represent significance between present nomograms and conventional staging systems;