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Table 4 Comparison of accuracy between present nomograms and four conventional staging systems via C-index

From: Novel postoperative nomograms for predicting individual prognoses of hepatitis B-related hepatocellular carcinoma with cirrhosis

Prognostic system

RFS

OS

C-index

95% CI

P1*

P2#

C-index

95% CI

P1*

P2#

Training cohort

Present nomogram

0.739

0.709–0.769

< 0.001

1.0 (Ref.)

0.789

0.759–0.819

< 0.001

1.0 (Ref.)

BCLC

0.615

0.587–0.643

< 0.001

< 0.001

0.633

0.601–0.665

< 0.001

< 0.001

AJCC8th

0.547

0.522–0.572

< 0.001

< 0.001

0.541

0.513–0.569

0.006

< 0.001

JIS score

0.541

0.517–0.566

0.001

< 0.001

0.524

0.497–0.551

0.09

< 0.001

HKLC

0.595

0.566–0.624

< 0.001

< 0.001

0.612

0.578–0.646

< 0.001

< 0.001

Validation cohort

Present nomogram

0.752

0.712–0.792

< 0.001

1.0 (Ref.)

0.813

0.775–0.851

< 0.001

1.0 (Ref.)

BCLC

0.615

0.583–0.647

< 0.001

< 0.001

0.636

0.589–0.683

< 0.001

< 0.001

AJCC8th

0.562

0.527–0.597

< 0.001

< 0.001

0.576

0.535–0.617

< 0.001

< 0.001

JIS score

0.554

0.521–0.587

0.002

< 0.001

0.565

0.524–0.606

0.002

< 0.001

HKLC

0.601

0.559–0.643

< 0.001

< 0.001

0.616

0.567–0.665

< 0.001

< 0.001

  1. Ref. reference; RFS, recurrence-free survival; OS, overall survival; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer staging system; AJCC8th, the eighth version of American Joint Committee on Cancer; JIS score, the Japan Integrated Staging Score; HKLC, the Hong Kong Liver Cancer prognostic classification scheme
  2. *Represent significance of staging systems;
  3. #Represent significance between present nomograms and conventional staging systems;
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BMC Surgery

ISSN: 1471-2482

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