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Table 1 Clinical differences between cirrhotic and non-cirrhotic patients with HCC

From: Novel postoperative nomograms for predicting individual prognoses of hepatitis B-related hepatocellular carcinoma with cirrhosis

Clinical parameters Non-cirrhosis (n = 328, %) Cirrhosis (n = 675, %) P-value Clinical parameters Non-cirrhosis (n = 328, %) Cirrhosis (n = 675, %) P-value
Gender 0.778 ALT (IU/L) 0.659
Male 275 (83.8) 570 (84.5)   ≥ 50 112 (34.1) 240 (35.5)  
Female 53 (16.2) 105 (15.5)   < 50 216 (65.9) 435 (64.5)  
Age (years) 0.014 AST (IU/L) 0.385
≥ 60 101 (30.9) 152 (22.5)   ≥ 40 153 (46.6) 334 (49.5)  
< 60 227 (69.1) 523 (77.5)   < 40 175 (53.4) 341 (50.5)  
HBV-DNA (copies/mL) 0.002 ALB (g/L) 0.054
≥ 103 169 (51.4) 397 (58.8)   ≥ 40 224 (68.2) 419 (62.1)  
< 103 159 (48.6) 278 (41.2)   < 40 104 (31.8) 256 (37.9)  
HBeAg 0.002 GGT (IU/L) 0.363
Positive 43 (13.1) 149 (22.1)   ≥ 60 170 (51.7) 329 (48.7)  
Negative 285 (86.9) 526 (77.9)   < 60 158 (48.3) 346 (51.3)  
AFP (ng/mL) 0.032 Child–pugh 0.961
≤ 20 116 (35.3) 227 (33.6)   A 323 (98.6) 666 (98.6)  
20–400 65 (19.7) 182 (27.0)   B 5 (1.4) 9 (1.4)  
≥ 400 147 (45.0) 266 (39.4)   Tumor diameter, mean (SD), cm 7.44 (3.91) 5.53 (3.25) < 0.001
WBC (× 109/L) < 0.001 Tumor number 0.015
≥ 4 297 (90.6) 502 (74.3)   Multi 36 (11.1) 113 (16.8)  
< 4 31 (9.4) 173 (25.7)   Single 292 (88.9) 562 (83.2)  
NEU (× 109/L) < 0.001 Differentiation 0.628
≥ 3.56 184 (56.0) 239 (35.4)   I + II 193 (58.8) 383 (56.8)  
< 3.56 144 (44.0) 436 (64.6)   III + IV 135 (41.2) 292 (43.2)  
LYM (× 109/L) 0.089 MVI 0.24
≥ 1.1 261 (79.5) 505 (74.8)   Present 128 (38.9) 238 (35.2)  
< 1.1 67 (20.5) 238 (35.2)   Absent 200 (61.1) 437 (64.8)  
PLT (× 109/L) < 0.001 Satellite lesion 0.328
≥ 100 275 (83.8) 409 (60.6)   Present 48 (14.5) 83 (12.3)  
< 100 53 (16.2) 266 (39.4)   Absent 280 (85.5) 592 (87.7)  
PT (s) < 0.001 Resection < 0.001
≥ 12.8 48 (14.5) 186 (27.5)   Anatomic 187 (56.9) 287 (42.5)  
< 12.8 280 (85.5) 489 (72.5)   Non-anatomic 141 (43.1) 388 (57.5)  
INR < 0.001 Blood loss (mL) 0.872
≥ 1.15 47 (14.2) 172 (25.5)   ≥ 400 272 (82.9) 567 (84.0)  
< 1.15 281 (85.8) 503 (74.5)   < 400 56 (17.1) 108 (16.0)  
Fib (g/L) < 0.001 Transfusion 0.734
≥ 2 297 (90.6) 538 (79.7)   Yes 51 (15.6) 109 (16.1)  
< 2 31 (9.4) 137 (20.3)   No 277 (84.4) 566 (83.9)  
TBIL (μmol/L) 0.02     
≥ 28 8 (2.3) 36 (5.4)      
< 28 320 (97.7) 639 (94.6)      
  1. Bold numbers indicate statistical significance
  2. HBV-DNA, hepatitis B virus deoxyribonucleic acid; HBeAg, hepatitis B e antigen; AFP, alpha-fetoprotein; WBC, white blood cell; NEU, neutrophil; LYM, lymphocyte; PLT, platelet; PT, prothrombin time; s, second; INR, international normalized ratio; Fib, fibrinogen; TBIL, total bilirubin; ALT, alanine transaminase; AST, aspartate aminotransferase; ALB, albumin; GGT, gamma-glutamyl transpeptidase; SD, standard deviation; MVI, microvascular invasion