Table 1 Clinical differences between cirrhotic and non-cirrhotic patients with HCC
Clinical parameters | Non-cirrhosis (n = 328, %) | Cirrhosis (n = 675, %) | P-value | Clinical parameters | Non-cirrhosis (n = 328, %) | Cirrhosis (n = 675, %) | P-value |
|---|---|---|---|---|---|---|---|
Gender | 0.778 | ALT (IU/L) | 0.659 | ||||
Male | 275 (83.8) | 570 (84.5) |  | ≥ 50 | 112 (34.1) | 240 (35.5) |  |
Female | 53 (16.2) | 105 (15.5) |  | < 50 | 216 (65.9) | 435 (64.5) |  |
Age (years) | 0.014 | AST (IU/L) | 0.385 | ||||
≥ 60 | 101 (30.9) | 152 (22.5) |  | ≥ 40 | 153 (46.6) | 334 (49.5) |  |
< 60 | 227 (69.1) | 523 (77.5) |  | < 40 | 175 (53.4) | 341 (50.5) |  |
HBV-DNA (copies/mL) | 0.002 | ALB (g/L) | 0.054 | ||||
≥ 103 | 169 (51.4) | 397 (58.8) |  | ≥ 40 | 224 (68.2) | 419 (62.1) |  |
< 103 | 159 (48.6) | 278 (41.2) |  | < 40 | 104 (31.8) | 256 (37.9) |  |
HBeAg | 0.002 | GGT (IU/L) | 0.363 | ||||
Positive | 43 (13.1) | 149 (22.1) |  | ≥ 60 | 170 (51.7) | 329 (48.7) |  |
Negative | 285 (86.9) | 526 (77.9) |  | < 60 | 158 (48.3) | 346 (51.3) |  |
AFP (ng/mL) | 0.032 | Child–pugh | 0.961 | ||||
≤ 20 | 116 (35.3) | 227 (33.6) |  | A | 323 (98.6) | 666 (98.6) |  |
20–400 | 65 (19.7) | 182 (27.0) |  | B | 5 (1.4) | 9 (1.4) |  |
≥ 400 | 147 (45.0) | 266 (39.4) |  | Tumor diameter, mean (SD), cm | 7.44 (3.91) | 5.53 (3.25) | < 0.001 |
WBC (× 109/L) | < 0.001 | Tumor number | 0.015 | ||||
≥ 4 | 297 (90.6) | 502 (74.3) |  | Multi | 36 (11.1) | 113 (16.8) |  |
< 4 | 31 (9.4) | 173 (25.7) |  | Single | 292 (88.9) | 562 (83.2) |  |
NEU (× 109/L) | < 0.001 | Differentiation | 0.628 | ||||
≥ 3.56 | 184 (56.0) | 239 (35.4) |  | I + II | 193 (58.8) | 383 (56.8) |  |
< 3.56 | 144 (44.0) | 436 (64.6) |  | III + IV | 135 (41.2) | 292 (43.2) |  |
LYM (× 109/L) | 0.089 | MVI | 0.24 | ||||
≥ 1.1 | 261 (79.5) | 505 (74.8) |  | Present | 128 (38.9) | 238 (35.2) |  |
< 1.1 | 67 (20.5) | 238 (35.2) |  | Absent | 200 (61.1) | 437 (64.8) |  |
PLT (× 109/L) | < 0.001 | Satellite lesion | 0.328 | ||||
≥ 100 | 275 (83.8) | 409 (60.6) |  | Present | 48 (14.5) | 83 (12.3) |  |
< 100 | 53 (16.2) | 266 (39.4) |  | Absent | 280 (85.5) | 592 (87.7) |  |
PT (s) | < 0.001 | Resection | < 0.001 | ||||
≥ 12.8 | 48 (14.5) | 186 (27.5) |  | Anatomic | 187 (56.9) | 287 (42.5) |  |
< 12.8 | 280 (85.5) | 489 (72.5) |  | Non-anatomic | 141 (43.1) | 388 (57.5) |  |
INR | < 0.001 | Blood loss (mL) | 0.872 | ||||
≥ 1.15 | 47 (14.2) | 172 (25.5) |  | ≥ 400 | 272 (82.9) | 567 (84.0) |  |
< 1.15 | 281 (85.8) | 503 (74.5) |  | < 400 | 56 (17.1) | 108 (16.0) |  |
Fib (g/L) | < 0.001 | Transfusion | 0.734 | ||||
≥ 2 | 297 (90.6) | 538 (79.7) |  | Yes | 51 (15.6) | 109 (16.1) |  |
< 2 | 31 (9.4) | 137 (20.3) |  | No | 277 (84.4) | 566 (83.9) |  |
TBIL (μmol/L) | 0.02 |  |  |  |  | ||
≥ 28 | 8 (2.3) | 36 (5.4) |  |  |  |  |  |
< 28 | 320 (97.7) | 639 (94.6) |  |  |  |  |  |