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Table 2 Uni- and multivariate analysis of preoperative predictors of AL

From: A preoperative prediction model based on Lymphocyte-C-reactive protein ratio predicts postoperative anastomotic leakage in patients with colorectal carcinoma: a retrospective study

  

Development cohort

Univariate analysis

Multivariate analysis

OR (95% CI)

p

OR (95% CI)

p

Age (years)

(≥ 60/ < 60)

5.046 (1.785-14.263)

 < 0.001

5.890 (1.701-27.623)

0.012

Sex

(Female/male)

0.501 (0.254-0.984)

0.041

0.420 (0.170-0.941)

0.044

BMI (Kg/m.2)

 

0.555 (0.294-1.047)

0.883

  

Smoking

(Yes/No)

1.176 (0.552-2.507)

0.674

  

Alcohol

 

1.666 (0.749-3.707)

0.207

  

Abdominal operation

(Yes/No)

0.798 (0.376-1.691)

0.555

  

T2DM

(Yes/No)

0.891 (0.310-2.565)

0.831

  

Cardiovascular disease

(Yes/No)

0.405 (0.096-1.707)

0.203

  

Hypertension

(Yes/No)

0.743 (0.369-1.495)

0.403

  

COPD

(Yes/No)

1.518 (0.519-4.444)

0.443

  

Hepatitis

(Yes/No)

0.648 (0.086-4.912)

0.672

  

Kidney disease

(Yes/No)

0.942 (0.122-7.266)

0.954

  

Hyperlipidemia

(Yes/No)

1.006 (0.130-7.792)

0.995

  

Transfusion history

(Yes/No)

0.957 (0.942-0.973)

0.157

  

Bowel preparation

(Yes/No)

0.999 (0.996-1.001)

0.797

  

Hemoglobin (g/L)

(≥ 90/ < 90)

0.190 (0.102-0.355)

 < 0.001

0.270 (0.120-0.643)

0.001

Tumor location

Transverse colon descending, sigmoid colon rectum

0.291 (0.009-9.958)

0.003

3.940 (2.100-8.610)

 < 0.001

NRS2002

(≥ 3/ < 3)

4.503 (2.319-8.743)

 < 0.001

3.240 (1.441-7.741)

0.006

LCR

(> 6000/ ≤ 6000)

0.171 (0.060-0.482)

 < 0.001

0.180 (0.053-0.530)

0.003

ASA score

(I/II/III/IV)

0.386 (0.002-63.381)

0.048

1.260 (0.681-2.310)

0.510

ECOG score

(0/1/2/3/4)

16.556 (0.610-49.231)

0.005

0.862 (0.490-1.510)

0.610

Total bilirubin(μmol/L)

 

1.007 (0.863-1.175)

0.280

  

Direct bilirubin(μmol/L)

1.537 (0.328-7.190)

0.088

  

ALT (IU/L)

 

0.930 (0.684-1.265)

0.895

  

AST (IU/L)

 

0.879 (0.617-1.254)

0.298

  

Prealbumin (g/L)

 

0.224 (0.004-12.783)

0.684

  

Albumin (g/L)

 

0.956 (0.611-1.497)

0.435

  

Urea (mmol/L)

 

0.329 (0.060-1.787)

0.848

  

Creatinine (μmol/L)

 

0.915 (0.776-1.080)

0.583

  

Uric acid (μmol/L)

 

1.002 (0.972-1.033)

0.980

  

White blood count (109/L)

0.466 (0.084-1.213)

0.497

  

Neutrophil count (109/L)

0.684 (0.103-1.641)

0.290

  

Lymphocyte count (109/L)

1.445 (0.227-10.360)

0.229

  

Hematocrit (%)

 

1.048 (0.937-1.172)

0.848

  

Platelet count (109/L)

 

0.973 (0.933-1.015)

0.468

  

APTT(s)

 

1.067 (0.689-1.651)

0.578

  

PT(s)

 

3.085 (0.188-50.598)

0.986

  

INR

 

6.011 (1.308-15.855)

0.646

  

C-reactive protein(ng/L)

2.364 (0.985-5.215)

0.001

1.031 (0.990-1.060)

0.040

  1. BMI body mass index, ASA American Society of Anesthesiologists, ECOG Eastern Cooperative Oncology Group, COPD Chronic Obstructive Pulmonary Disease, NRS2002 Nutritional Risk Screening 2002, LCR Lymphocyte-C-reactive protein Ratio, ALT alanine aminotransferase, AST aspartate aminotransferase, T2DM type 2 diabetes mellitus, APTT activated partial thromboplasin time, PT prothrombin time, INR international normalized ration
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