Is total thyroidectomy with bilateral central neck dissection the only surgery for papillary thyroid carcinoma patients with clinically involved central nodes?

Table 5 Associations between maximum CLNM size ≥ 2 mm and clinicopathological characteristics of PTC patients with pathologically-proven pN1a (n = 538)

Clinicopathological characteristics	Univariate analysis			Multivariate analysis
Clinicopathological characteristics	Adjusted OR	95% CI	p-value	Adjusted OR	95% CI	p-value
Unilateral cN1a (Ref = cN0)	3.600	1.807–7.174	< 0.001	3.667	1.803–7.460	< 0.001
Male sex (Ref = female)	0.987	0.662–1.471	0.949
Patient age (per 10 years)	0.946	0.931–0.962	< 0.001	0.946	0.930–0.962	< 0.001
Tumor size (per 0.1 cm)	1.174	0.886–1.555	0.265
Multifocality (Ref = absent)	1.035	0.681–1.574	0.872
ETE (Ref = absent)	1.117	0.758–1.646	0.577
Chronic lymphocytic thyroiditis (Ref = absent)	1.166	0.764–1.779	0.476
Contralateral lobe involvement (Ref = absent)	1.117	0.743–1.681	0.595
Contralateral central neck metastasis (Ref = absent)	1.329	0.897–1.970	0.157

PTC papillary thyroid carcinoma, CLNM central lymph node metastasis, cN0 no clinically involved central lymph node, cN1a clinically involved central lymph node, ETE extrathyroidal extension, OR odds ratio, CI confidence interval, Ref reference

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