Is total thyroidectomy with bilateral central neck dissection the only surgery for papillary thyroid carcinoma patients with clinically involved central nodes?

Table 4 Associations between number of CLNM > 5 and clinicopathological characteristics of PTC patients with pathologically-proven pN1a (n = 538)

Clinicopathological characteristics	Univariate analysis			Multivariate analysis
Clinicopathological characteristics	Adjusted OR	95% CI	p-value	Adjusted OR	95% CI	p-value
Unilateral cN1a (Ref = cN0)	2.149	1.273–3.628	0.004	2.240	1.260–3.979	0.006
Male sex (Ref = female)	1.538	0.989–2.393	0.056
Patient age (per 10 years)	0.966	0.948–0.985	0.001	0.968	0.948–0.988	0.002
Tumor size (per 0.1 cm)	1.742	1.313–2.311	< 0.001	1.613	1.180–2.974	0.003
Multifocality (Ref = absent)	2.030	1.296–3.180	0.002	1.799	1.088–2.974	0.022
ETE (Ref = absent)	1.631	1.010–2.632	0.045	1.607	0.956–2.699	0.073
Chronic lymphocytic thyroiditis (Ref = absent)	1.083	0.675–1.739	0.740
Contralateral lobe involvement (Ref = absent)	1.092	0.689–1.729	0.709
Contralateral central neck metastasis (Ref = absent)	4.416	2.827–6.898	< 0.001	3.550	2.215–5.690	< 0.001

PTC papillary thyroid carcinoma, CLNM central lymph node metastasis, cN0 no clinically involved central lymph node, cN1a clinically involved central lymph node, ETE extrathyroidal extension, OR odds ratio, CI confidence interval, Ref reference

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