Is total thyroidectomy with bilateral central neck dissection the only surgery for papillary thyroid carcinoma patients with clinically involved central nodes?

Table 3 Associations between contralateral central neck metastasis and clinicopathological characteristics of PTC patients (n = 619^a)

Clinicopathological characteristics	Univariate analysis			Multivariate analysis
Clinicopathological characteristics	Adjusted OR	95% CI	p-value	Adjusted OR	95% CI	p-value
Unilateral cN1a (Ref = cN0)	1.672	0.970–2.882	0.064	1.312	0.734–2.342	0.359
Male sex (Ref = female)	2.254	1.485–3.421	< 0.001	1.798	1.153–2.801	0.010
Patient age (per 10 years)	0.965	0.948–0.982	< 0.001	0.975	0.957–0.994	0.009
Tumor size (per 0.1 cm)	1.661	1.270–2.173	< 0.001	1.605	1.200–2.145	0.001
Multifocality (Ref = absent)	2.056	1.314–3.215	0.002	2.496	1.539–4.046	< 0.001
ETE (Ref = absent)	0.998	0.664–1.501	0.992
Chronic lymphocytic thyroiditis (Ref = absent)	0.808	0.516–1.266	0.352
Ipsilateral central neck metastasis (Ref = absent)	4.149	2.493–6.903	< 0.001	3.255	1.901–5.574	< 0.001

PTC papillary thyroid carcinoma, cN0 no clinically involved central lymph node, cN1a clinically involved central lymph node, ETE extrathyroidal extension, OR odds ratio, CI confidence interval, Ref reference. ^aPatients with only unilateral PTC were included, and patients with incidentally found contralateral lobe PTMC on permanent pathology were excluded

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