Table 1 Pathological tumor characteristics of cN0 and unilateral cN1a PTC patients
Pathological characteristics | cN0 no. (%) | Unilateral cN1a no. (%) | p-value |
|---|---|---|---|
Total (n = 899) | 793 | 106 | |
Sex | |||
Female | 605 (76.3) | 81 (77.4) | 0.808 |
Male | 188 (23.7) | 25 (22.6) | |
Age (year) | |||
Mean ± SD | 47.1 ± 11.9 | 43.4 ± 10.7 | 0.002 |
< 55 | 565 (71.2) | 91 (85.8) | |
≥ 55 | 222 (28.8) | 15 (14.2) | |
Main tumor laterality | |||
Right | 448 (56.5) | 43 (40.6) | 0.002 |
Left | 345 (43.5) | 63 (59.4) | |
Tumor size (cm) | |||
Mean ± SD | 1.17 ± 0.7 | 1.20 ± 0.5 | 0.603 |
≤ 1.0 | 392 (49.4) | 44 (41.5) | |
1.0–2.0 | 326 (41.1) | 56 (52.8) | |
2.0–4.0 | 70 (8.8) | 6 (5.7) | |
> 4.0 | 5 (0.6) | 0 (0) | 0.611 |
Bilaterality | |||
Absent | 548 (69.1) | 71 (67.0) | 0.657 |
Present | 245 (30.9) | 35 (33.0) | |
Multifocality | |||
Absent | 592 (74.7) | 70 (66.0) | 0.059 |
Present | 201 (25.3) | 36 (34.0) | |
BRAF mutation (n = 634) | |||
Absent | 75 (13.1) | 9 (14.8) | 0.715 |
Present | 498 (86.9) | 52 (85.2) | |
Extrathyroidal extension | |||
Absent | 277 (34.9) | 42 (39.6) | 0.343 |
Present | 516 (65.1) | 64 (60.4) | |
Chronic lymphocytic thyroiditis | |||
Absent | 563 (71.0) | 62 (58.5) | 0.009 |
Present | 230 (29.0) | 44 (41.5) | |
Number of retrieved central LNs (no.) | |||
Mean (range) ± SD | 9.7 (1.0–34.0) ± 5 | 11.7 (2.0–36.0) ± 6 | < 0.001 |
Central LN metastasis | |||
Absent | 337 (42.5) | 24 (22.5) | < 0.001 |
Present | 456 (57.5) | 82 (77.4) | |
Ipsilateral central neck metastasis | |||
Absent | 36 (7.9) | 2 (2.4) | 0.076 |
Present | 420 (92.1) | 80 (97.6) | |
Contralateral central neck metastasis* | |||
Absent | 297 (65.1) | 51 (62.2) | 0.609 |
Present | 159 (34.9) | 31 (37.8) | |
Number of metastatic CLNs (no.) | |||
Mean(range) ± SD | 2.22(1.0–20.0) ± 2.8 | 2.24(1.0–15.0) ± 2.9 | 0.004 |
≦ 5 | 375 (82.2) | 56 (68.3) | |
> 5 | 81 (17.8) | 26 (31.7) | |
Retrieved CLNM size (mm) | |||
< 2.0 | 152 (33.3) | 10 (12.2) | < 0.001 |
≧ 2.0 | 304 (66.7) | 72 (82.8) | |
Loco-regional recurrence | |||
Absent | 779 (98.2) | 104 (98.1) | 1.000 |
Present | 14 (1.8) | 2 (1.9) | |