Table 1 Demographic and clinical characteristics associated with chemotherapeutic resistance in GC patients
Chemotherapeutic resistance | |||
|---|---|---|---|
Variables | No (n = 119) | Yes (n = 41) | P-value |
Age (year) | 48.7 ± 5.4 | 46.5 ± 6.2 | 0.032a* |
BMI (kg/m2) | 20.9 ± 2.2 | 21.1 ± 2.3 | 0.620a |
Gender, n (%) | – | – | 0.543c |
Male | 78 (65.5) | 29 (70.7) | – |
Female | 41 (34.5) | 12 (29.3) | – |
ASA physical status, n (%) | – | – | 0.964c |
I–II | 75 (63.0) | 26 (63.4) | – |
III–IV | 44 (37.0) | 15 (36.6) | – |
Current smoker, n (%) | 19 (16.0) | 14 (34.1) | 0.013c* |
Heavy drinker, n (%) | 15 (12.6) | 6 (14.6) | 0.740c |
Diabetes, n (%) | 11 (9.2) | 4 (9.8) | 0.923d |
Hypertension, n (%) | 17 (14.3) | 8(19.5) | 0.427c |
ECOG status, n (%) | – | – | 0.515c |
0 | 26 (21.8) | 7 (17.1) | – |
1 | 93 (78.2) | 34 (82.9) | – |
Types of surgery, n (%) | – | – | 0.850c |
Total gastrectomy | 33 (27.7) | 12 (29.3) | – |
Partial gastrectomy | 86 (72.3) | 29 (70.7) | – |
Surgical approach | – | – | 0.416c |
Laparotomy | 37 (31.1) | 10 (24.4) | – |
Laparoscopic | 82 (68.9) | 31 (75.6) | – |
Operation time (min) | 225.6 ± 37.5 | 220.8 ± 33.7 | 0.470a |
Estimated blood loss (ml) | 290.5 ± 135.6 | 262.5 ± 145.3 | 0.265b |
Chemotherapy regimen, n (%) | – | – | 0.679c |
SOX | 45 (37.8) | 17 (41.5) | – |
XELOX | 74 (62.2) | 24 (58.5) | – |
Cycles of chemotherapy | 4.7 ± 0.8 | 4.4 ± 0.8 | 0.040a* |
Tumor location, n (%) | – | – | 0.711c |
Upper 1/3 | 15 (12.6) | 4 (9.8) | – |
Middle 1/3 | 43 (36.1) | 13 (31.7) | – |
Low 1/3 | 61 (51.3) | 24 (58.5) | – |
Tumor size (cm) | 3.5 ± 1.4 | 4.1 ± 1.7 | 0.027b* |
Tumor differentiation, n (%) | – | – | 0.417c |
Poorly | 82(68.9) | 31 (75.6) | – |
Moderately/well | 37(31.1) | 10 (24.4) | – |
Lauren’s classification | – | – | 0.834c |
Intestinal | 12 (10.1) | 5 (12.2) | – |
Diffuse | 79 (66.4) | 28 (68.3) | – |
Mixed | 28 (23.5) | 8 (19.5) | – |
Clinical TNM stage | – | – | 0.838c |
II | 16 (13.4) | 5 (12.2) | – |
III | 103 (86.6) | 36 (87.8) | – |
Pathological TNM stage | – | – | 0.666c |
II | 17 (14.3) | 7 (17.1) | – |
III | 102 (85.7) | 34 (82.9) | – |
Her–2 | – | – | 0.738c |
Positive | 17 (14.3) | 5 (12.2) | – |
Negative | 102 (85.7) | 36 (87.8) | – |