Table 1 Clinical characteristics
Items | Before IPTW | After IPTW | ||||
|---|---|---|---|---|---|---|
FPX (N = 1177) | LMWH (N = 1252) | SMD | FPX | LMWH | SMD | |
Demographic characteristics | ||||||
Age (years), mean ± SD | 60.3 ± 16.4 | 61.1 ± 14.5 | 0.051 | 60.9 ± 15.8 | 60.8 ± 15.0 | 0.009 |
Male, No. (%) | 510 (43.3) | 498 (39.8) | 0.072 | 40.5 | 42.2 | 0.033 |
Height (cm), mean ± SD | 163.8 ± 8.3 | 162.7 ± 8.6 | 0.133 | 163.2 ± 8.3 | 163.3 ± 8.7 | 0.004 |
Weight (Kg), mean ± SD | 65.2 ± 11.4 | 65.7 ± 11.7 | 0.040 | 65.4 ± 11.4 | 65.5 ± 11.9 | 0.004 |
BMI (Kg/m2), mean ± SD | 24.3 ± 3.7 | 24.8 ± 3.9 | 0.137 | 24.6 ± 3.8 | 24.6 ± 3.9 | 0.001 |
Risk factors, No. (%) | ||||||
History of bleeding | 21 (1.8) | 19 (1.5) | 0.021 | 1.7 | 1.8 | 0.008 |
History of hypertension | 402 (34.2) | 451 (36.0) | 0.039 | 35.4 | 35.3 | 0.002 |
History of diabetes mellitus | 93 (7.9) | 111 (8.9) | 0.035 | 8.1 | 9.0 | 0.031 |
History of surgery | 292 (24.8) | 353 (28.2) | 0.077 | 25.2 | 27.5 | 0.052 |
Major surgery within one month | 5 (0.4) | 3 (0.2) | 0.032 | 0.4 | 0.3 | 0.024 |
Other risk factors | 1177 (100.0) | 1252 (100.0) | < 0.001 | 100.0 | 100.0 | < 0.001 |
DVT score, mean ± SD | 10.2 ± 4.1 | 9.7 ± 3.9 | 0.145 | 10.0 ± 3.9 | 10.0 ± 4.1 | 0.002 |
Vital signs, mean ± SD | ||||||
DBP (mmHg) | 78.6 ± 11.2 | 78.0 ± 10.7 | 0.057 | 78.8 ± 11.3 | 77.8 ± 10.8 | 0.091 |
SBP (mmHg) | 136.0 ± 17.8 | 135.6 ± 17.0 | 0.022 | 136.4 ± 17.7 | 135.2 ± 17.1 | 0.069 |
HR (times/min) | 79.4 ± 8.9 | 79.2 ± 8.8 | 0.016 | 79.3 ± 8.8 | 79.4 ± 9.0 | 0.012 |
Laboratory indexes, mean ± SD | ||||||
HB (g/L) | 128.4 ± 15.6 | 128.5 ± 14.9 | 0.001 | 128.5 ± 15.4 | 128.5 ± 15.2 | 0.002 |
PLT (X109/L) | 233.1 ± 71.6 | 239.1 ± 74.1 | 0.082 | 236.3 ± 73.4 | 236.4 ± 72.7 | 0.002 |
PT (s) | 12.8 ± 5.2 | 12.6 ± 5.4 | 0.044 | 12.8 ± 5.5 | 12.9 ± 8.1 | 0.017 |
aPTT (s) | 30.5 ± 7.1 | 30.3 ± 8.4 | 0.032 | 30.8 ± 7.6 | 30.3 ± 8.1 | 0.054 |
TT (s) | 18.7 ± 8.0 | 18.5 ± 2.5 | 0.034 | 18.6 ± 7.0 | 18.5 ± 2.5 | 0.005 |
D-dimer (mg/L) | 5.8 ± 12.4 | 4.6 ± 11.7 | 0.096 | 5.2 ± 11.8 | 5.1 ± 12.1 | 0.002 |
INR | 1.1 ± 0.9 | 1.2 ± 3.1 | 0.078 | 1.1 ± 1.0 | 1.2 ± 3.0 | 0.077 |
PTA (%) | 106.1 ± 19.3 | 108.3 ± 37.7 | 0.071 | 106.7 ± 19.4 | 106.8 ± 33.6 | 0.003 |
FIB (g/L) | 2.9 ± 0.8 | 3.0 ± 0.8 | 0.095 | 3.0 ± 0.8 | 3.0 ± 0.8 | 0.006 |
Scr (μmol/L) | 71.2 ± 40.2 | 70.8 ± 45.9 | 0.008 | 71.0 ± 39.9 | 71.0 ± 46.0 | 0.001 |
Ccr (mL/min) | 102.5 ± 38.6 | 101.4 ± 36.6 | 0.031 | 101.8 ± 37.6 | 101.8 ± 37.1 | < 0.001 |
Type of surgery, No. (%) | ||||||
Hip fracture | 186 (15.8) | 156 (12.5) | 0.096 | 14.1 | 14.0 | 0.001 |
Hip replacement | 160 (13.6) | 201 (16.1) | 0.069 | 14.8 | 14.8 | 0.002 |
Knee replacement | 296 (25.1) | 453 (36.2) | 0.241 | 30.8 | 30.8 | < 0.001 |
Upper limb surgery | 37 (3.1) | 7 (0.6) | 0.193 | 1.8 | 1.6 | 0.018 |
Other trauma surgery | 465 (39.5) | 429 (34.3) | 0.109 | 37.0 | 37.1 | 0.003 |
No surgery | 72 (6.1) | 54 (4.3) | 0.081 | 5.2 | 5.3 | 0.001 |
Type of anesthesia, No. (%) | ||||||
General anesthesia | 357 (30.3) | 285 (22.8) | 0.172 | 26.3 | 26.0 | 0.007 |
Regional anesthesia | 691 (58.7) | 847 (67.7) | 0.186 | 63.4 | 63.7 | 0.007 |
Local anesthesia | 17 (1.4) | 20 (1.6) | 0.013 | 1.6 | 1.4 | 0.012 |
Combined anesthesia | 18 (1.5) | 16 (1.3) | 0.021 | 1.6 | 1.3 | 0.031 |
No anesthesia | 94 (8.0) | 84 (6.7) | 0.049 | 7.1 | 7.6 | 0.020 |
Duration of surgery (hours), mean ± SD | 1.9 ± 1.1 | 1.8 ± 0.9 | 0.181 | 1.8 ± 1.0 | 1.9 ± 1.1 | 0.007 |
Duration of anesthesia (hours), mean ± SD | 3.6 ± 24.5 | 3.0 ± 19.5 | 0.031 | 3.4 ± 22.7 | 4.0 ± 28.7 | 0.021 |
Duration of medication (days), mean ± SD | 8.1 ± 12.2 | 7.5 ± 11.5 | 0.050 | 7.7 ± 11.7 | 7.8 ± 12.7 | 0.009 |
HLOS (days), mean ± SD | 10.9 ± 6.4 | 10.9 ± 5.6 | 0.007 | 10.7 ± 5.9 | 11.0 ± 6.2 | 0.054 |