Table 2 Univariate and multivariate testing of tumor and surgery characteristics and their respective influence on OS and RCR
Stage | Hazard Ratio | p (univariate) | p (multiple) | Hazard Ratio | p (univariate) | p (multiple) |
|---|---|---|---|---|---|---|
Regional control rate | Overall survival | |||||
Tumor origin | < 0.01 | < 0.01 | 0.02 | 0.01 | ||
Larynx vs. Hypopharynx | 0.4 [0.2–0.7] | < 0.01 | 0.4 [0.2–0.7] | < 0.01 | ||
Oral Cavity vs. Hypopharynx | 0.6 [0.4–1.1] | 0.12 | 0.6 [0.4–1.1] | 0.12 | ||
Oropharynx vs. Hypopharynx | 0.6 [0.4–1.0] | 0.05 | 0.7 [0.4–1.2] | 0.16 | ||
Oral Cavity vs. Larynx | 1.7 [1.0–3.1] | 0.06 | 1.5 [0.9–2.8] | 0.15 | ||
Oropharynx vs. Oral Cavity | 0.9 [0.5–1.6] | 0.78 | 1.1 [0.6–1.9] | 0.80 | ||
Oropharynx vs. Larynx | 1.5 [0.6–1.5] | 0.12 | 1.6 [0.9–2.8] | 0.08 | ||
Pathological tumor category | 0.13 | 0.07 | < 0.01 | < 0.01 | ||
pT2 vs. pT1 | 1.6 [0.8–3.2] | 1.7 [0.8–3.6] | 0.16 | |||
pT3 vs. pT1 | 1.1 [0.5–2.1] | 1.2 [0.6–2.7] | 0.57 | |||
pT4 vs. pT1 | 1.7 [0.8–3.4] | 3.1 [1.5–6.5] | < 0.01 | |||
pT3 vs. pT2 | 0.6 [0.4–1.0] | 0.7 [0.4–1.2] | 0.25 | |||
pT4 vs. pT3 | 0.6 [0.4–1.0] | 2.5 [1.5–4.2] | < 0.01 | |||
pT4 vs. pT2 | 1.0 [0.6–1.7] | 1.8 [1.1–3.0] | 0.01 | |||
Clinical lymph node category | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||
cN1 vs. cN0 | 1.9 [1.1–3.4] | 0.03 | 1.8 [1.0–3.4] | 0.06 | ||
cN2 vs. cN0 | 2.4 [1.5–3.8] | < 0.01 | 3.0 [1.8–4.9] | < 0.01 | ||
cN3 vs. cN0 | 5.4 [1.3–22.7] | 0.02 | 9.4 [2.2–40.0] | < 0.01 | ||
cN2 vs. cN1 | 1.3 [0.7–2.1] | 0.40 | 1.6 [0.9–2.8] | 0.09 | ||
cN3 vs. cN1 | 2.6 [0.6–11.2] | 0.20 | 4.9 [1.1–22.2] | 0.04 | ||
cN3 vs. cN2 | 2.3 [0.6–9.6] | 0.24 | 3.0 [0.7–12.3] | 0.13 | ||
Pathological lymph node category | < 0.01 | < 0.01 | < 0.01 | < 0.01 | ||
pN1 vs. pN0 | 1.9 [1.0–3.5] | 0.05 | 2.6 [1.4–5.0] | < 0.01 | ||
pN2 vs. pN0 | 4.0 [2.5–6.4] | < 0.01 | 5.2 [3.1–8.7] | < 0.01 | ||
pN2 vs. pN1 | 2.1 [1.3–3.7] | < 0.01 | 2.0 [1.2–3.3] | 0.01 | ||
Development of distant metastasis | 6.6, [4.5–9.6] | < 0.01 | 0.25 | 9.8 [6.5–14.6] | < 0.01 | < 0.01 |
Postoperative (Chemo-) radiation | 0.9, [0.6–1.3] | 0.51 | < 0.01 | 0.5 [0.3–0.8] | < 0.01 | 0.13 |
Neck dissection ipsilateral | 0.7 [0.3–2.0] | 0.56 | 0.37 | 0.9 [0.3–3.0] | 0.93 | 0.64 |
Level I ipsilateral | 1.3 [0.8–2.0] | 0.30 | 0.25 | 1.0 [0.6–1.7] | 0.96 | 0.68 |
Level II ipsilateral | 0.5 [0.3–0.9] | 0.01 | 0.72 | 0.5 [0.3–0.9] | 0.02 | 0.83 |
Level III ipsilateral | 0.6 [0.3–1.1] | 0.07 | 0.18 | 0.6 [0.3–1.0] | 0.05 | 0.96 |
Level IV ipsilateral | 1.1 [0.7–1.8] | 0.62 | 0.44 | 1.2 [0.8–1.9] | 0.42 | 0.61 |
Level V ipsilateral | 0.8 [0.2–2.5] | 0.68 | 0.44 | 0.7 [0.2–2.9] | 0.63 | 0.27 |
Neck dissection contralateral | 1.0 [0.7–1.4] | 0.93 | 0.40 | 1.3 [0.9–2.0] | 0.14 | 0.79 |
Level I contralateral | 1.6 [0.9–2.9] | 0.10 | 0.17 | 1.8 [1.0–3.3] | 0.04 | 0.07 |
Level II contralateral | 1.0 [0.7–1.4] | 0.89 | 0.88 | 1.3 [0.9–1.9] | 0.23 | 0.21 |
Level III contralateral | 1.0 [0.7–1.4] | 0.96 | 0.70 | 1.3 [0.9–1.9] | 0.20 | 0.83 |
Level IV contralateral | 1.2 [0.7–2.4] | 0.50 | 0.48 | 1.6 [0.8–2.9] | 0.16 | 0.86 |
Level V contralateral | 0.0 [0.0–∞] | 0.15 | 0.23 | 0.0 [0–∞] | 0.20 | 0.30 |