Table 4 Univariate and multivariate analyses of prognostic factors associated with RFS
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
HR (95%CI) | P-value | HR (95% CI) | P-value | |
Age | 1.016(0.998–1.034) | 0.074 | ||
Sex male | 0.808(0.539–1.210) | 0.301 | ||
serum CA 19-9 (U/mL) > 37 | 1.928(1.263–2.945) | 0.002 | 1.403 (0.742–2.655) | 0.298 |
Serum CEA (ng/mL) > 5 | 1.631(1.025–2.593) | 0.039 | 1.175 (0.567–2.436) | 0.664 |
Hemoglobin | 0.994(0.982–1.006) | 0.306 | ||
NLR > 2.6 | 1.527(1.036–2.251) | 0.032 | 1.239 (0.635–2.417) | 0.530 |
Gallstones | 1.506(0.995–2.279) | 0.053 | ||
Tumor size > 3 cm | 0.892(0.570–1.396) | 0.617 | ||
T III–IV | 1.112 (0.904–1.368) | 0.314 | ||
Poor differentiation | 1.640(1.084–2.484) | 0.019 | 1.779 (0.937–3.378) | 0.078 |
Lymph node metastases | 3.318 (1.128–7.048) | 0.014 | 0.950 (0.481–1.879) | 0.884 |
TNM stage III + IV | 1.617 (1.037–2.520) | 0.034 | 2.308 (1.051–7.567) | 0.047 |
GNRI < 98 | 3.870 (2.560–5.851) | < 0.001 | 2.964 (1.577–5.571) | 0.001 |