Preoperative C-reactive protein to albumin ratio predicts anastomotic leakage after esophagectomy for thoracic esophageal cancer: a single-center retrospective cohort study

Table 4 Uni- and multivariate analyses of preoperative and surgical factors for anastomotic leakage

Variables	Analysis with CAR		Analysis with albumin		Analysis with CRP
Variables	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
BMI ≥ 22.1 kg/m² (vs < 22.1 kg/m²)	1.69 (0.80–3.56)	0.17	1.84 (0.88–3.88)	0.107	1.74 (0.82–3.66)	0.147
Operation time > 565 min (vs ≤ 565 min)	1.95 (0.87–4.37)	0.106	2.06 (0.92–4.59)	0.079	1.96 (0.87–4.41)	0.102
Blood loss ≥ 480 mL (vs < 480 mL)	1.42 (0.65–3.11)	0.226	1.52 (0.70–3.31)	0.231	1.45 (0.66–3.17)	0.35
CAR ≥ 0.0139 (vs < 0.0139)	3.02 (1.01–9.06)	0.048
Albumin ≤ 3.8 g/dL (vs > 3.8 g/dL)			1.69 (0.81–3.54)	0.162
CRP ≥ 0.06 mg/dL (vs < 0.06 mg/dL)					2.26 (0.82–6.21)	0.113

BMI, body mass index; CAR, C-reactive protein-to-albumin ratio; CRP: C-reactive protein;
OR, odds ratio; 95%CI, 95% confidence interval

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