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Table 6 Physical function

From: A systematic review and meta-analysis of risks and benefits with breast reduction in the public healthcare system: priorities for further research

Author
Year
Country
Study design Number of patients Withdrawals—dropouts Intervention
Breast reduction
Mean (SD)
Control
No surgery
Mean (SD)
P values of intergroup difference if not state otherwise
Comments Directness* Study limitations* Precision*
Freire
2007
Brazil [37]
RCT 100
I: 50
C: 50
8
I: 4
C: 4
HAQ-20
Pre-op: 0.44 (0.38)
6 months post-op:
0.12 (0.23)
HAQ-20
Baseline: 0.48 (0.40)
6 months after baseline:
0.46 (0.30) p < 0.001
MD 0.34
HAQ-20 has 8 dimensions that evaluate aspects of daily life: dress, get up without support, feed yourself, walk on the flat, take a shower, reach objects, grasp objects, domestic tasks. It gives a summary score between 0 (able) to 3 (disabled)  +  ?/− ?
Neto
2008
Brazil [36]
RCT
(same as above)
100
I: 50
C: 50
8
I: 4
C: 4
Roland-Morris questionnaire
Pre-op: 5.9 (4.9)
6 months post-op: 1.2 (1.9)
Intragroup difference, p < 0.001
Roland-Morris questionnaire
Baseline: 6.2 (4.8)
6 months after baseline: 6.2 (3.9)
Intragroup difference, N.S
MD 0.5 (p < 0.001)
Roland-Morris questionnaire measures functional capacity and is scored from 0 (best performance) to 24 (worst performance)
Intergroup difference NR
 + 
Saariniemi
2008
Finland [34]
RCT 82
I: 40
C: 42
8
I: 11
C: 7
SF-36 physical summary score
Pre-op: 42 (8.6)
6 months post-op: 51.7 (SD NR)
SF-36 physical summary score
Baseline: 42.6 (8.9)
6 months after baseline: 43.3 (SD NR)
MD 8.4 (95% CI 5.8 to 11.8), p < 0.0001
The SF-36 physical summary score represents a norm-based scoring with a mean value of 50 and a SD of 10 (range 0–100). The higher the score, the greater the satisfaction. No MID is established ?/ +  ?  + 
Andrade
2018
Brazil [42]
Non-randomized controlled study 100
I: 50
C: 50
0 Breast Q physical well-being
Post-op median: 79 (48–100)
Breast Q physical well-being
pre-op median: 48 (0–83)
p = 0.001
Total scores for the subscale physical well-being range from 0 to 100. The higher the score, the greater the satisfaction. There are no MID for subscales  +  ?/ + 
Hermans
2005
The Netherlands [43]
Non-randomized controlled study 165
I: 94
C: 71
10
I: 10
C: 0
SF-36 physical function
Postop mean value after 12–24 months: 84.76
SF-36 physical function
Before surgery
77.46 p < 0.05
SF-36 is scored 0–100 where a higher score indicates better health status. MID not possible to establish ? ?/− ?
     EQ 5D-daily activities
Postop mean after 12–24 months:
No problems 72.3
Some problems 25.3
Many problems 2.4
EQ 5D-daily activities
Before surgery
No problems 46.5
Some problems 50.7
Many problems 2.8
p < 0.005
    
     DAS-59 I have physical disabilities because of my features
12–24 months postoperatively:
Almost never 89%
Sometimes 6%
Always often 5%
DAS-59 I have physical disabilities because of my features
Almost never 6%
Sometimes 23%
Always often 72%
p = NS
    
  1. DAS-59 Derriford Appearance Scale 59, EQ-5D EuroQol 5 Dimensions, HAQ-20 Stanford Health Assessment Questionnaire, MID minimally clinically important difference, MD mean difference, NR not reported, NS non-significant, SF36 Short Form Health Survey 36
  2. * + No or minor problems; ? Some problems; - Major problems