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Table 2 Baseline characteristics and pathologic outcomes of rectal cancer patients by CRM involvement status

From: An observational study of patho-oncological outcomes of various surgical methods in total mesorectal excision for rectal cancer: a single center analysis

Variable

n

CRM involvement

Yes

No

 

All

300

30 (10%)

270 (90%)

P value

Age

 

60.0 ± 12.4

63.0 ± 10.9

0.185

Gender

   

0.262

 female

108 (36%)

8 (7.4%)

100 (92.6%)

 

 male

192 (64%)

22 (11.5%)

170 (88.5%)

 

Surgery method

   

0.037*

 RS

88 (29.3%)

3 (3.4%)

85 (96.6%)

 

 LS

37 (12.3%)

6 (16.2%)

31 (83.8%)

 

 Open surgery

175 (58.3%)

21 (12%)

154 (88%)

 

Tumor size

   

< 0.001*

  > 5 cm

55 (18.3%)

14 (25.5%)

41 (74.5%)

 

 ≦5 cm

245 (81.7%)

16 (6.5%)

229 (93.5%)

 

Histologic grade

   

0.001*

 WD

35 (11.7%)

0 (0%)

35 (100%)

 

 MD

251 (83.7%)

25 (10.0%)

226 (90.0%)

 

 PD

14 (4.7%)

5 (35.7%)

9 (64.3%)

 

LVI

   

< 0.001*

 yes

109 (36.3%)

24 (22.0%)

85 (78.0%)

 

 no

191 (63.7%)

6 (3.1%)

185 (96.9%)

 

PNI

   

0.023*

 yes

70 (23.3%)

12 (17.1%)

58 (82.9%)

 

 no

230 (76.7%)

18 (7.8%)

212 (92.2%)

 

Stage

   

< 0.001*

 pCR

50 (16.7%)

0 (0%)

50(100%)

 

 I

82 (27.3%)

1 (1.2%)

81 (98.8%)

 

 II

73 (24.3%)

7 (9.6%)

66 (90.4%)

 

 III

95 (31.7%)

22 (23.2%)

73 (76.8%)

 

Tumor depth

   

< 0.001*

 (y)pT0

53 (17.7%)

0 (0%)

53 (100%)

 

 (y)pT1

31 (10.3%)

0 (0%)

31 (100%)

 

 (y)pT2

71 (23.7%)

1 (1.4%)

70 (98.6%)

 

  (y)pT3

145 (48.3%)

29 (20%)

116 (80%)

 

Pre-OP CCRT

   

< 0.001*

 yes

156 (52%)

4 (2.6%)

152 (97.4%)

 

 no

144 (48%)

26 (18.1%)

118 (81.9%)

 

TRS after CCRT

156

4 (2.6%)

152 (97.4%)

0.002*

 0

50 (32.05%)

0 (0%)

50 (100%)

 

 1

61 (29.10%)

0 (0%)

61 (100%)

 

 2

34 (21.9%)

2 (5.9%)

32 (94.1%)

 

 3

11 (7.1%)

2 (18.2%)

9 (81.8%)

 

CR after CCRT

156

4 (2.6%)

152 (97.4%)

0.164

 yes

50 (32.1%)

0 (0%)

50 (100%)

 

 no

106 (67.9%)

4 (3.8%)

102 (96.2%)

 
  1. CRM circumferential margin; SD standard deviation; OR odds ratio; CI confidence interval; RS robotic surgery; LS laparoscopic surgery; CCRT concurrent chemoradiotherapy; WD well-differentiated; MD moderately-differentiated; PD poorly-differentiated; LVI lymphovascular invasion; PNI perineural invasion; AJCC American Joint Commission on Cancer; pCR pathologic complete response; OP operative, TRS tumor regression score; *P < 0.05