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Table 1 Clinical and biochemical data of examined patients

From: AGLR is a novel index for the prognosis of hepatocellular carcinoma patients: a retrospective study

Parameter Training cohort Validation cohort p value
(n = 248) (n = 247)
Basic information    
 Age (years) 49.33 ± 11.35 50.96 ± 11.80 0.119
 Gender: n (%)    
  Female 29 (11.7) 34 (13.8) 0.489
  Male 219 (88.3) 213 (86.2)  
 Family history: n (%)    
  No 216 (87.0) 219 (88.7) 0.435
  Yes 32 (13.0) 28 (11.3)  
 Drinking: n (%)    
  No 140 (56.5) 133 (53.8) 0.560
  Yes 108 (43.5) 114 (46.2)  
 Smoking: n (%)    
  No 148 (59.7) 152 (61.5) 0.577
  Yes 100 (40.3) 95 (38.5)  
 HBsAg: n (%)    
  Negative 41 (16.5) 34 (13.8) 0.391
  Positive 207 (83.5) 213 (86.2)  
 Minimally invasive surgery: n (%)    
  No 184 (74.2) 180 (72.9) 0.739
  Yes 64 (25.8) 67 (27.1)  
Lab check data    
 WBC (× 109/L) 6.04 ± 2.01 6.39 ± 2.20 0.061
 NEUT (× 109/L) 3.65 ± 1.71 3.92 ± 1.73 0.081
 LYMPH (× 109/L) 1.64 ± 0.57 1.73 ± 0.65 0.105
 Platelets (× 109/L) 173.96 ± 75.18 181.23 ± 79.27 0.096
 Albumin (g/L) 39.07 ± 4.59 39.65 ± 4.66 0.220
 Globulin (g/L) 31.01 ± 5.80 30.35 ± 6.18 0.215
 TBIL (μmol/L) 15.91 ± 14.33 16.45 ± 16.07 0.747
 DBIL (μmol/L) 6.33 ± 12.38 6.92 ± 13.17 0.689
 ALT (U/L) 45.12 ± 42.93 51.08 ± 46.33 0.783
 AST (U/L) 49.98 ± 48.83 51.91 ± 57.49 0.697
 ALP (U/L) 95.69 ± 65.26 92.29 ± 42.60 0.493
 GGT (U/L): median, range 67.62, 10.7–335.1 72.19, 10.0–351.76 0.854
 AGLR level: median, range 90.63, 19.43–441.72 88.83, 16.07–462.16 0.521
 AFP (ng/mL): median, range 246.7, 0.20–32,800 220.7, 0.60–25,410 0.363
Pathological features    
 Cirrhosis: n (%)    
  No 24 (10.0) 13 (5.3) 0.062
  Yes 224 (90.0) 234 (94.7)  
 Tumor size (cm) 7.81 ± 4.68 7.12 ± 4.11 0.085
 Tumor number: n (%)    
  Single 190 (76.6) 188 (76.1) 0.896
  Multiple 58 (23.4) 59 (23.9)  
 TNM stage: n (%)    
 I-II 136 (54.8) 124 (50.2) 0.302
 III-IV 112 (45.2) 123 (49.8)  
 MVI: n (%)    
  No 201 (81.0) 188 (76.1) 0.181
  Yes 47 (19.0) 59 (23.9)  
 Recurrence: n (%)    
  No 158 (63.7) 148 (59.9) 0.385
  Yes 90 (36.3) 99 (40.1)  
  1. N, number of patients; HBsAg, hepatitis B surface antigen; WBC, white blood cell; LYMPH, lymphocyte count; TBIL, total bilirubin; DBIL, direct bilirubin; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; AGLR, ALP plus GGT to LYMPH; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis; MVI, microvascular invasion