Influence of diabetes on short-term outcome after major hepatectomy: an underestimated risk?

BMC Surgery

Table 3 Multivariate analysis of association of preoperative diabetes mellitus, overweight, and obesity with postoperative outcome variables

		Diabetes mellitus		Overweight		Obesity
	n	OR (95%CI)	p	OR (95%CI)	p	OR (95%CI)	p
30-day mortality	405	1.82 (0.6; 5.47)	0.29	0.36 (0.12; 1.08)	0.07	0.47 (0.09; 2.49)	0.38
90-day mortality	395	1.22 (0.5; 2.95)	0.66	0.85 (0.39; 1.86)	0.69	0.48 (0.12; 1.94)	0.3
Morbidity	389	2.44 (1.15; 5.19)	0.02	1.46 (0.87; 2.43)	0.15	1.06 (0.49; 2.28)	0.89
Clavien–Dindo grade IV	414	3.6 (1.49; 8.66)	0.004	1.56 (0.73; 3.35)	0.25	1.76 (0.58; 5.36)	0.32
Unplanned readmission rate	342	2.44 (1.03; 5.78)	0.04	1 (0.53; 1.87)	0.99	1.07 (0.41; 2.76)	0.89
Bile leakage	389	2.06 (1.01; 4.21)	0.046	1.42 (0.8; 2.5)	0.23	1.46 (0.62; 3.41)	0.38
Posthepatectomy haemorrhage	389	0.73 (0.17; 3.03)	0.66	1.4 (0.5; 3.93)	0.52	1.98 (0.44; 8.94)	0.38
Posthepatectomy liver failure	389	1.76 (0.81; 3.82)	0.15	1.63 (0.86; 3.11)	0.13	0.54 (0.16; 1.82)	0.32

Bold values represent statistically significant results (p-values < 0.05)
OR odds ratio, 95% CI 95% confidence interval. Results for the following model variables are shown in the supplementary appendix: underweight, age ≥ 60 years, male gender, arterial hypertension, chronic renal failure, preoperative chemotherapy, extended right hemihepatectomy, extended left hemihepatectomy, biliodigestive anastomosis, benign indication, colorectal liver metastasis and cholangiocarcinoma. The endpoints bile leakage, post-hepatectomy haemorrhage and post-hepatectomy liver failure were defined as proposed by the International Study Group of Liver Surgery [27,28,29]

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