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Table 9 Tumor characteristics and surgical outcomes in Low and High PNI groups according to liver fictional preserve

From: Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function

  LHL15 ≥ 0.9   LHL15 < 0.9  
Variables Low PNI (n = 7) High PNI (n = 146) p value Low PNI (n = 10) High PNI (n = 26) p value
Tumor size (cm) 7.0 (2.0–13.0) 4.0 (0.5–24.0) n.s 3 (1.1–15.0) 3.5 (0.7–20.0) n.s
Multiple tumor 2 (29%) 38 (26%) n.s 5 (50%) 4 (15%) n.s
AFP (ng/ml) 40 (2–33,430) 9 (1–253,875) n.s 122 (9–60,105) 29 (4–88,940) n.s
DCP (mAU/ml) 1501 (28–85,330) 88 (1–286,400) n.s 260 (14–29,182) 237 (10–174,400) n.s
BCLC stage    n.s    n.s
 0 0 (0%) 13 (9%)   0 (0%) 4 (15%)  
 A 6 (86%) 91 (62%)   7 (70%) 17 (65%)  
 B 0 (0%) 31 (21%)   3 (30%) 4 (15%)  
 C 1 (14%) 11 (8%)   0 (0%) 1 (4%)  
Within Milan criteria 9 (53%) 98 (57%) n.s 7 (70%) 20 (77%) n.s
Tumor differentiation    n.s    
 Well 2 (29%) 34 (29%)   0 (0%) 6 (29%) n.s
 Moderately 3 (43%) 68 (56%)   7 (78%) 12 (57%)  
 Poorly 2 (29%) 19 (16%)   2 (22%) 3 (14%)  
Vascular invasion       
 vp ( +) 4 (57%) 48 (38%) n.s 5 (56%) 7 (33%) n.s
 vv ( +) 1 (14%) 11 (9%) n.s 0 (0%) 0 (0%) n.s
Operation time (minutes) 361 (170–526) 350 (137–983) n.s 277 (159–413) 274 (127–580) n.s
Blood loss (ml) 2865 (520–10,382) 1064 (0–36,000) n.s 1711 (1270–4192) 1500 (56–7341) n.s
 ≥ 2 sectionectomy 3 (43%) 52 (36%) n.s 0 (0%) 2 (8%) n.s
Complications (C–D ≥ IIIa) 1 (14%) 29 (20%) n.s 4 (40%) 4 (15%) n.s
Mortality 1 (14%) 8 (6%) n.s 1 (10%) 0 (0%) n.s
PT-INR on POD5 1.19 (1.10–1.71) 1.12 (0.92–1.52) n.s 1.21 (0.98–1.49) 1.18 (0.94–1.51) n.s
Total bilirubin on POD5 (mg/dl) 1.5 (0.7–11.2) 0.9 (0.3–8.3) 0.024 1.2 (0.5–2.8) 1.0 (0.4–4.7) n.s
  1. Differences were considered significant at p < 0.05, shown as italic values
  2. AFP alpha fetoprotein, DCP des-γ-carboxyprothrombin, BCLC stage Barcelona clinic liver cancer stage, C–D Clavien–Dindo, POD postoperative day, vp ( +) portal vein invasion including microvascular invasion, vv ( +) hepatic vein invasion including microvascular invasion
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